André D J Mckenzie, Taylor R Garrett, Eryn L Werry, Michael Kassiou. ACS Chem Neurosci 2022
Times Cited: 1
Times Cited: 1
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A His-155 to Tyr polymorphism confers gain-of-function to the human P2X7 receptor of human leukemic lymphocytes.
Giulio Cabrini, Simonetta Falzoni, Sylvia L Forchap, Patrizia Pellegatti, Alessandra Balboni, Paola Agostini, Antonio Cuneo, Gianluigi Castoldi, O Roberto Baricordi, Francesco Di Virgilio. J Immunol 2005
Giulio Cabrini, Simonetta Falzoni, Sylvia L Forchap, Patrizia Pellegatti, Alessandra Balboni, Paola Agostini, Antonio Cuneo, Gianluigi Castoldi, O Roberto Baricordi, Francesco Di Virgilio. J Immunol 2005
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P2X7 Receptors: An Untapped Target for the Management of Cardiovascular Disease.
Brandon G Shokoples, Pierre Paradis, Ernesto L Schiffrin. Arterioscler Thromb Vasc Biol 2021
Brandon G Shokoples, Pierre Paradis, Ernesto L Schiffrin. Arterioscler Thromb Vasc Biol 2021
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High sensitivity of CD4+CD25+ regulatory T cells to extracellular metabolites nicotinamide adenine dinucleotide and ATP: a role for P2X7 receptors.
Fred Aswad, Hiroki Kawamura, Gunther Dennert. J Immunol 2005
Fred Aswad, Hiroki Kawamura, Gunther Dennert. J Immunol 2005
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Development and clinical translation of P2X7 receptor antagonists: A potential therapeutic target in coronary artery disease?
Elijah Genetzakis, Jayson Gilchrist, Michael Kassiou, Gemma A Figtree. Pharmacol Ther 2022
Elijah Genetzakis, Jayson Gilchrist, Michael Kassiou, Gemma A Figtree. Pharmacol Ther 2022
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The evolution of P2X7 antagonists with a focus on CNS indications.
Jason C Rech, Anindya Bhattacharya, Michael A Letavic, Brad M Savall. Bioorg Med Chem Lett 2016
Jason C Rech, Anindya Bhattacharya, Michael A Letavic, Brad M Savall. Bioorg Med Chem Lett 2016
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Full-Length P2X7 Structures Reveal How Palmitoylation Prevents Channel Desensitization.
Alanna E McCarthy, Craig Yoshioka, Steven E Mansoor. Cell 2019
Alanna E McCarthy, Craig Yoshioka, Steven E Mansoor. Cell 2019
100
A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptor.
B J Gu, W Zhang, R A Worthington, R Sluyter, P Dao-Ung, S Petrou, J A Barden, J S Wiley. J Biol Chem 2001
B J Gu, W Zhang, R A Worthington, R Sluyter, P Dao-Ung, S Petrou, J A Barden, J S Wiley. J Biol Chem 2001
100
Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel.
Olivier Delaneau, Jonathan Marchini. Nat Commun 2014
Olivier Delaneau, Jonathan Marchini. Nat Commun 2014
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Essential role for Ca2+ in regulation of IL-1beta secretion by P2X7 nucleotide receptor in monocytes, macrophages, and HEK-293 cells.
Lalitha Gudipaty, Jonathan Munetz, Philip A Verhoef, George R Dubyak. Am J Physiol Cell Physiol 2003
Lalitha Gudipaty, Jonathan Munetz, Philip A Verhoef, George R Dubyak. Am J Physiol Cell Physiol 2003
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ATP acts as an agonist to promote stimulus-induced secretion of IL-1 beta and IL-18 in human blood.
D G Perregaux, P McNiff, R Laliberte, M Conklyn, C A Gabel. J Immunol 2000
D G Perregaux, P McNiff, R Laliberte, M Conklyn, C A Gabel. J Immunol 2000
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Alerting and tuning the immune response by extracellular nucleotides.
Andrea la Sala, Davide Ferrari, Francesco Di Virgilio, Marco Idzko, Johannes Norgauer, Giampiero Girolomoni. J Leukoc Biol 2003
Andrea la Sala, Davide Ferrari, Francesco Di Virgilio, Marco Idzko, Johannes Norgauer, Giampiero Girolomoni. J Leukoc Biol 2003
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Pathophysiology and therapeutic potential of purinergic signaling.
Geoffrey Burnstock. Pharmacol Rev 2006
Geoffrey Burnstock. Pharmacol Rev 2006
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A truncated P2X7 receptor variant (P2X7-j) endogenously expressed in cervical cancer cells antagonizes the full-length P2X7 receptor through hetero-oligomerization.
Ying-Hong Feng, Xin Li, Liqin Wang, Lingying Zhou, George I Gorodeski. J Biol Chem 2006
Ying-Hong Feng, Xin Li, Liqin Wang, Lingying Zhou, George I Gorodeski. J Biol Chem 2006
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Antagonism of the ATP-gated P2X7 receptor: a potential therapeutic strategy for cancer.
Matthew Drill, Nigel C Jones, Martin Hunn, Terence J O'Brien, Mastura Monif. Purinergic Signal 2021
Matthew Drill, Nigel C Jones, Martin Hunn, Terence J O'Brien, Mastura Monif. Purinergic Signal 2021
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Rapid secretion of interleukin-1beta by microvesicle shedding.
A MacKenzie, H L Wilson, E Kiss-Toth, S K Dower, R A North, A Surprenant. Immunity 2001
A MacKenzie, H L Wilson, E Kiss-Toth, S K Dower, R A North, A Surprenant. Immunity 2001
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Protein structure predictions to atomic accuracy with AlphaFold.
John Jumper, Demis Hassabis. Nat Methods 2022
John Jumper, Demis Hassabis. Nat Methods 2022
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Cryopyrin activates the inflammasome in response to toxins and ATP.
Sanjeev Mariathasan, David S Weiss, Kim Newton, Jacqueline McBride, Karen O'Rourke, Meron Roose-Girma, Wyne P Lee, Yvette Weinrauch, Denise M Monack, Vishva M Dixit. Nature 2006
Sanjeev Mariathasan, David S Weiss, Kim Newton, Jacqueline McBride, Karen O'Rourke, Meron Roose-Girma, Wyne P Lee, Yvette Weinrauch, Denise M Monack, Vishva M Dixit. Nature 2006
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Adenosine triphosphate-induced shedding of CD23 and L-selectin (CD62L) from lymphocytes is mediated by the same receptor but different metalloproteases.
B Gu, L J Bendall, J S Wiley. Blood 1998
B Gu, L J Bendall, J S Wiley. Blood 1998
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Targeting the P2X7 receptor in rheumatoid arthritis: biological rationale for P2X7 antagonism.
Iain B McInnes, Simon Cruwys, Keith Bowers, Martin Braddock. Clin Exp Rheumatol 2014
Iain B McInnes, Simon Cruwys, Keith Bowers, Martin Braddock. Clin Exp Rheumatol 2014
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Extracellular ATP causes of loss of L-selectin from human lymphocytes via occupancy of P2Z purinocepters.
G P Jamieson, M B Snook, P J Thurlow, J S Wiley. J Cell Physiol 1996
G P Jamieson, M B Snook, P J Thurlow, J S Wiley. J Cell Physiol 1996
100
Targeting P2X4 and P2X7 receptors in multiple sclerosis.
María Domercq, C Matute. Curr Opin Pharmacol 2019
María Domercq, C Matute. Curr Opin Pharmacol 2019
100
P2X7 Receptor: A Potential Therapeutic Target for Depression?
Jan M Deussing, Eduardo Arzt. Trends Mol Med 2018
Jan M Deussing, Eduardo Arzt. Trends Mol Med 2018
100
Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation.
Welbeck Danquah, Catherine Meyer-Schwesinger, Björn Rissiek, Carolina Pinto, Arnau Serracant-Prat, Miriam Amadi, Domenica Iacenda, Jan-Hendrik Knop, Anna Hammel, Philine Bergmann,[...]. Sci Transl Med 2016
Welbeck Danquah, Catherine Meyer-Schwesinger, Björn Rissiek, Carolina Pinto, Arnau Serracant-Prat, Miriam Amadi, Domenica Iacenda, Jan-Hendrik Knop, Anna Hammel, Philine Bergmann,[...]. Sci Transl Med 2016
100
The P2X7 receptor: a new therapeutic target in Alzheimer's disease.
Peter Illes, Patrizia Rubini, Lumei Huang, Yong Tang. Expert Opin Ther Targets 2019
Peter Illes, Patrizia Rubini, Lumei Huang, Yong Tang. Expert Opin Ther Targets 2019
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The P2X7 Receptor: A Promising Pharmacological Target in Diabetic Retinopathy.
Matteo Tassetto, Anna Scialdone, Anna Solini, Francesco Di Virgilio. Int J Mol Sci 2021
Matteo Tassetto, Anna Scialdone, Anna Solini, Francesco Di Virgilio. Int J Mol Sci 2021
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The P2X7 purinergic receptor: An emerging therapeutic target in cardiovascular diseases.
Zhe Chen, Lu He, Lanfang Li, Linxi Chen. Clin Chim Acta 2018
Zhe Chen, Lu He, Lanfang Li, Linxi Chen. Clin Chim Acta 2018
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The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease.
Rachael Bartlett, Leanne Stokes, Ronald Sluyter. Pharmacol Rev 2014
Rachael Bartlett, Leanne Stokes, Ronald Sluyter. Pharmacol Rev 2014
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Mechanisms of release of nucleotides and integration of their action as P2X- and P2Y-receptor activating molecules.
Eduardo R Lazarowski, Richard C Boucher, T Kendall Harden. Mol Pharmacol 2003
Eduardo R Lazarowski, Richard C Boucher, T Kendall Harden. Mol Pharmacol 2003
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P2X7 receptor cell surface expression and cytolytic pore formation are regulated by a distal C-terminal region.
Megan L Smart, Ben Gu, Rekha G Panchal, James Wiley, Brett Cromer, David A Williams, Steven Petrou. J Biol Chem 2003
Megan L Smart, Ben Gu, Rekha G Panchal, James Wiley, Brett Cromer, David A Williams, Steven Petrou. J Biol Chem 2003
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Genescript: DNA sequence annotation pipeline.
Alexander K Hudek, Joseph Cheung, Andrew P Boright, Stephen W Scherer. Bioinformatics 2003
Alexander K Hudek, Joseph Cheung, Andrew P Boright, Stephen W Scherer. Bioinformatics 2003
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ATP-mediated killing of intracellular mycobacteria by macrophages is a P2X(7)-dependent process inducing bacterial death by phagosome-lysosome fusion.
I P Fairbairn, C B Stober, D S Kumararatne, D A Lammas. J Immunol 2001
I P Fairbairn, C B Stober, D S Kumararatne, D A Lammas. J Immunol 2001
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Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor.
Pablo Pelegrin, Annmarie Surprenant. EMBO J 2006
Pablo Pelegrin, Annmarie Surprenant. EMBO J 2006
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Structural basis for subtype-specific inhibition of the P2X7 receptor.
Akira Karasawa, Toshimitsu Kawate. Elife 2016
Akira Karasawa, Toshimitsu Kawate. Elife 2016
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P2RX7 Purinoceptor as a Therapeutic Target-The Second Coming?
Chris N J Young, Dariusz C Górecki. Front Chem 2018
Chris N J Young, Dariusz C Górecki. Front Chem 2018
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Two haplotypes of the P2X(7) receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1beta secretion.
Leanne Stokes, Stephen J Fuller, Ronald Sluyter, Kristen K Skarratt, Ben J Gu, James S Wiley. FASEB J 2010
Leanne Stokes, Stephen J Fuller, Ronald Sluyter, Kristen K Skarratt, Ben J Gu, James S Wiley. FASEB J 2010
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ATP receptors and giant cell formation.
F Di Virgilio, S Falzoni, P Chiozzi, J M Sanz, D Ferrari, G N Buell. J Leukoc Biol 1999
F Di Virgilio, S Falzoni, P Chiozzi, J M Sanz, D Ferrari, G N Buell. J Leukoc Biol 1999
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The potential involvement of P2X7 receptor in COVID-19 pathogenesis: A new therapeutic target?
Paulo A F Pacheco, Robson X Faria. Scand J Immunol 2021
Paulo A F Pacheco, Robson X Faria. Scand J Immunol 2021
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Recent Advances in CNS P2X7 Physiology and Pharmacology: Focus on Neuropsychiatric Disorders.
Anindya Bhattacharya. Front Pharmacol 2018
Anindya Bhattacharya. Front Pharmacol 2018
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P2X7 Receptor as a Potential Target for Major Depressive Disorder.
Zeyi Huang, Sijie Tan. Curr Drug Targets 2021
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The P2X7 receptor: a key player in IL-1 processing and release.
Davide Ferrari, Cinzia Pizzirani, Elena Adinolfi, Roberto M Lemoli, Antonio Curti, Marco Idzko, Elisabeth Panther, Francesco Di Virgilio. J Immunol 2006
Davide Ferrari, Cinzia Pizzirani, Elena Adinolfi, Roberto M Lemoli, Antonio Curti, Marco Idzko, Elisabeth Panther, Francesco Di Virgilio. J Immunol 2006
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P2X7 receptor antagonists: a patent review (2010-2015).
Jin-Hee Park, Yong-Chul Kim. Expert Opin Ther Pat 2017
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A role for mitogen-activated protein kinase(Erk1/2) activation and non-selective pore formation in P2X7 receptor-mediated thymocyte death.
Rodolphe Auger, Iris Motta, Karim Benihoud, David M Ojcius, Jean M Kanellopoulos. J Biol Chem 2005
Rodolphe Auger, Iris Motta, Karim Benihoud, David M Ojcius, Jean M Kanellopoulos. J Biol Chem 2005
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Ensembl 2022.
Fiona Cunningham, James E Allen, Jamie Allen, Jorge Alvarez-Jarreta, M Ridwan Amode, Irina M Armean, Olanrewaju Austine-Orimoloye, Andrey G Azov, If Barnes, Ruth Bennett,[...]. Nucleic Acids Res 2022
Fiona Cunningham, James E Allen, Jamie Allen, Jorge Alvarez-Jarreta, M Ridwan Amode, Irina M Armean, Olanrewaju Austine-Orimoloye, Andrey G Azov, If Barnes, Ruth Bennett,[...]. Nucleic Acids Res 2022
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The potential of P2X7 receptors as a therapeutic target, including inflammation and tumour progression.
Geoffrey Burnstock, Gillian E Knight. Purinergic Signal 2018
Geoffrey Burnstock, Gillian E Knight. Purinergic Signal 2018
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An Arg307 to Gln polymorphism within the ATP-binding site causes loss of function of the human P2X7 receptor.
Ben J Gu, Ronald Sluyter, Kristen K Skarratt, Anne N Shemon, Lan-Phuong Dao-Ung, Stephen J Fuller, Julian A Barden, Alison L Clarke, Steven Petrou, James S Wiley. J Biol Chem 2004
Ben J Gu, Ronald Sluyter, Kristen K Skarratt, Anne N Shemon, Lan-Phuong Dao-Ung, Stephen J Fuller, Julian A Barden, Alison L Clarke, Steven Petrou, James S Wiley. J Biol Chem 2004
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P2X7 receptor antagonism in amyotrophic lateral sclerosis.
Ronald Sluyter, Rachael Bartlett, Diane Ly, Justin J Yerbury. Neural Regen Res 2017
Ronald Sluyter, Rachael Bartlett, Diane Ly, Justin J Yerbury. Neural Regen Res 2017
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Highly accurate protein structure prediction with AlphaFold.
John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko,[...]. Nature 2021
John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko,[...]. Nature 2021
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ATP-induced killing of mycobacteria by human macrophages is mediated by purinergic P2Z(P2X7) receptors.
D A Lammas, C Stober, C J Harvey, N Kendrick, S Panchalingam, D S Kumararatne. Immunity 1997
D A Lammas, C Stober, C J Harvey, N Kendrick, S Panchalingam, D S Kumararatne. Immunity 1997
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The P2X7 receptor: A main player in inflammation.
Elena Adinolfi, Anna Lisa Giuliani, Elena De Marchi, Anna Pegoraro, Elisa Orioli, Francesco Di Virgilio. Biochem Pharmacol 2018
Elena Adinolfi, Anna Lisa Giuliani, Elena De Marchi, Anna Pegoraro, Elisa Orioli, Francesco Di Virgilio. Biochem Pharmacol 2018
100
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.