Ton Fang, Goun Je, Peter Pacut, Kiandokht Keyhanian, Jeff Gao, Mehdi Ghasemi. Cells 2022
Times Cited: 2
Times Cited: 2
Times Cited
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A randomized trial of mexiletine in ALS: Safety and effects on muscle cramps and progression.
Michael D Weiss, Eric A Macklin, Zachary Simmons, Angela S Knox, David J Greenblatt, Nazem Atassi, Michael Graves, Nicholas Parziale, Johnny S Salameh, Colin Quinn,[...]. Neurology 2016
Michael D Weiss, Eric A Macklin, Zachary Simmons, Angela S Knox, David J Greenblatt, Nazem Atassi, Michael Graves, Nicholas Parziale, Johnny S Salameh, Colin Quinn,[...]. Neurology 2016
50
Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts' Recommendations: Choosing Optimal Monitoring Tools.
Magdalena Kuzma-Kozakiewicz, Andrzej Marchel, Anna Kaminska, Malgorzata Gawel, Jan Sznajder, Anna Figiel-Dabrowska, Arkadiusz Nowak, Edyta Maj, Natalia Ewa Krzesniak, Bartlomiej H Noszczyk,[...]. Stem Cells Int 2018
Magdalena Kuzma-Kozakiewicz, Andrzej Marchel, Anna Kaminska, Malgorzata Gawel, Jan Sznajder, Anna Figiel-Dabrowska, Arkadiusz Nowak, Edyta Maj, Natalia Ewa Krzesniak, Bartlomiej H Noszczyk,[...]. Stem Cells Int 2018
50
Ultra-high-dose methylcobalamin in amyotrophic lateral sclerosis: a long-term phase II/III randomised controlled study.
Ryuji Kaji, Takashi Imai, Yasuo Iwasaki, Koichi Okamoto, Masanori Nakagawa, Yasuo Ohashi, Takao Takase, Takahisa Hanada, Hiroki Shimizu, Kunio Tashiro,[...]. J Neurol Neurosurg Psychiatry 2019
Ryuji Kaji, Takashi Imai, Yasuo Iwasaki, Koichi Okamoto, Masanori Nakagawa, Yasuo Ohashi, Takao Takase, Takahisa Hanada, Hiroki Shimizu, Kunio Tashiro,[...]. J Neurol Neurosurg Psychiatry 2019
50
RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.
Yasushi Ito, Dimitry Ofengeim, Ayaz Najafov, Sudeshna Das, Shahram Saberi, Ying Li, Junichi Hitomi, Hong Zhu, Hongbo Chen, Lior Mayo,[...]. Science 2016
Yasushi Ito, Dimitry Ofengeim, Ayaz Najafov, Sudeshna Das, Shahram Saberi, Ying Li, Junichi Hitomi, Hong Zhu, Hongbo Chen, Lior Mayo,[...]. Science 2016
50
Meta-analysis of pharmacogenetic interactions in amyotrophic lateral sclerosis clinical trials.
Ruben P A van Eijk, Ashley R Jones, William Sproviero, Aleksey Shatunov, Pamela J Shaw, P Nigel Leigh, Carolyn A Young, Christopher E Shaw, Gabriele Mora, Jessica Mandrioli,[...]. Neurology 2017
Ruben P A van Eijk, Ashley R Jones, William Sproviero, Aleksey Shatunov, Pamela J Shaw, P Nigel Leigh, Carolyn A Young, Christopher E Shaw, Gabriele Mora, Jessica Mandrioli,[...]. Neurology 2017
50
Smoking and the risk of amyotrophic lateral sclerosis: a systematic review and meta-analysis.
Alvaro Alonso, Giancarlo Logroscino, Miguel A Hernán. J Neurol Neurosurg Psychiatry 2010
Alvaro Alonso, Giancarlo Logroscino, Miguel A Hernán. J Neurol Neurosurg Psychiatry 2010
50
Comprehensive rehabilitative care across the spectrum of amyotrophic lateral sclerosis.
Sabrina Paganoni, Chafic Karam, Nanette Joyce, Richard Bedlack, Gregory T Carter. NeuroRehabilitation 2015
Sabrina Paganoni, Chafic Karam, Nanette Joyce, Richard Bedlack, Gregory T Carter. NeuroRehabilitation 2015
50
AAV as a gene transfer vector for the treatment of neurological disorders: novel treatment thoughts for ALS.
Mark E Hester, Kevin D Foust, Rita W Kaspar, Brian K Kaspar. Curr Gene Ther 2009
Mark E Hester, Kevin D Foust, Rita W Kaspar, Brian K Kaspar. Curr Gene Ther 2009
50
Therapeutic applications of mesenchymal stem cells for amyotrophic lateral sclerosis.
Christina M Lewis, Masatoshi Suzuki. Stem Cell Res Ther 2014
Christina M Lewis, Masatoshi Suzuki. Stem Cell Res Ther 2014
50
Masitinib as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomized clinical trial.
Jesus S Mora, Angela Genge, Adriano Chio, Conrado J Estol, Delia Chaverri, Maria Hernández, Saúl Marín, Javier Mascias, Gabriel E Rodriguez, Monica Povedano,[...]. Amyotroph Lateral Scler Frontotemporal Degener 2020
Jesus S Mora, Angela Genge, Adriano Chio, Conrado J Estol, Delia Chaverri, Maria Hernández, Saúl Marín, Javier Mascias, Gabriel E Rodriguez, Monica Povedano,[...]. Amyotroph Lateral Scler Frontotemporal Degener 2020
50
Novel STMN2 Variant Linked to Amyotrophic Lateral Sclerosis Risk and Clinical Phenotype.
Frances Theunissen, Ryan S Anderton, Frank L Mastaglia, Loren L Flynn, Samantha J Winter, Ian James, Richard Bedlack, Stuart Hodgetts, Sue Fletcher, Steve D Wilton,[...]. Front Aging Neurosci 2021
Frances Theunissen, Ryan S Anderton, Frank L Mastaglia, Loren L Flynn, Samantha J Winter, Ian James, Richard Bedlack, Stuart Hodgetts, Sue Fletcher, Steve D Wilton,[...]. Front Aging Neurosci 2021
50
Safety and Effectiveness of Long-term Intravenous Administration of Edaravone for Treatment of Patients With Amyotrophic Lateral Sclerosis.
Simon Witzel, André Maier, Robert Steinbach, Julian Grosskreutz, Jan C Koch, Anastasia Sarikidi, Susanne Petri, René Günther, Joachim Wolf, Andreas Hermann,[...]. JAMA Neurol 2022
Simon Witzel, André Maier, Robert Steinbach, Julian Grosskreutz, Jan C Koch, Anastasia Sarikidi, Susanne Petri, René Günther, Joachim Wolf, Andreas Hermann,[...]. JAMA Neurol 2022
50
The "dying-back" phenomenon of motor neurons in ALS.
Michal Dadon-Nachum, Eldad Melamed, Daniel Offen. J Mol Neurosci 2011
Michal Dadon-Nachum, Eldad Melamed, Daniel Offen. J Mol Neurosci 2011
50
Riluzole exerts transient modulating effects on cortical and axonal hyperexcitability in ALS.
Nimeshan Geevasinga, Parvathi Menon, Karl Ng, Mehdi Van Den Bos, Karen Byth, Matthew C Kiernan, Steve Vucic. Amyotroph Lateral Scler Frontotemporal Degener 2016
Nimeshan Geevasinga, Parvathi Menon, Karl Ng, Mehdi Van Den Bos, Karen Byth, Matthew C Kiernan, Steve Vucic. Amyotroph Lateral Scler Frontotemporal Degener 2016
50
Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer.
Martine J Piccart-Gebhart, Marion Procter, Brian Leyland-Jones, Aron Goldhirsch, Michael Untch, Ian Smith, Luca Gianni, Jose Baselga, Richard Bell, Christian Jackisch,[...]. N Engl J Med 2005
Martine J Piccart-Gebhart, Marion Procter, Brian Leyland-Jones, Aron Goldhirsch, Michael Untch, Ian Smith, Luca Gianni, Jose Baselga, Richard Bell, Christian Jackisch,[...]. N Engl J Med 2005
50
Efficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.
Ryosuke Oki, Yuishin Izumi, Koji Fujita, Ryosuke Miyamoto, Hiroyuki Nodera, Yasutaka Sato, Satoshi Sakaguchi, Hiroshi Nokihara, Kazuaki Kanai, Taiji Tsunemi,[...]. JAMA Neurol 2022
Ryosuke Oki, Yuishin Izumi, Koji Fujita, Ryosuke Miyamoto, Hiroyuki Nodera, Yasutaka Sato, Satoshi Sakaguchi, Hiroshi Nokihara, Kazuaki Kanai, Taiji Tsunemi,[...]. JAMA Neurol 2022
50
Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial.
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50
Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study.
Ammar Al-Chalabi, Andrea Calvo, Adriano Chio, Shuna Colville, Cathy M Ellis, Orla Hardiman, Mark Heverin, Robin S Howard, Mark H B Huisman, Noa Keren,[...]. Lancet Neurol 2014
Ammar Al-Chalabi, Andrea Calvo, Adriano Chio, Shuna Colville, Cathy M Ellis, Orla Hardiman, Mark Heverin, Robin S Howard, Mark H B Huisman, Noa Keren,[...]. Lancet Neurol 2014
50
Investigation of the therapeutic effects of edaravone, a free radical scavenger, on amyotrophic lateral sclerosis (Phase II study).
Hiide Yoshino, Akio Kimura. Amyotroph Lateral Scler 2006
Hiide Yoshino, Akio Kimura. Amyotroph Lateral Scler 2006
50
An analysis of extended survival in patients with amyotrophic lateral sclerosis treated with riluzole.
M Riviere, V Meininger, P Zeisser, T Munsat. Arch Neurol 1998
M Riviere, V Meininger, P Zeisser, T Munsat. Arch Neurol 1998
50
Antibody-Based Therapeutic Interventions for Amyotrophic Lateral Sclerosis: A Systematic Literature Review.
Amélie Poulin-Brière, Edris Rezaei, Silvia Pozzi. Front Neurosci 2021
Amélie Poulin-Brière, Edris Rezaei, Silvia Pozzi. Front Neurosci 2021
50
Potential Environmental Factors in Amyotrophic Lateral Sclerosis.
Björn Oskarsson, D Kevin Horton, Hiroshi Mitsumoto. Neurol Clin 2015
Björn Oskarsson, D Kevin Horton, Hiroshi Mitsumoto. Neurol Clin 2015
50
Intraspinal stem cell transplantation for amyotrophic lateral sclerosis: Ready for efficacy clinical trials?
Nazem Atassi, Ettore Beghi, Miguel Blanquer, Nicholas M Boulis, Roberto Cantello, Claudia Caponnetto, Adriano Chiò, Stephen B Dunnett, Eva L Feldman, Angelo Vescovi,[...]. Cytotherapy 2016
Nazem Atassi, Ettore Beghi, Miguel Blanquer, Nicholas M Boulis, Roberto Cantello, Claudia Caponnetto, Adriano Chiò, Stephen B Dunnett, Eva L Feldman, Angelo Vescovi,[...]. Cytotherapy 2016
50
Nonmotor Symptoms in Amyotrophic Lateral Sclerosis: A Systematic Review.
Ton Fang, Felix Jozsa, Ammar Al-Chalabi. Int Rev Neurobiol 2017
Ton Fang, Felix Jozsa, Ammar Al-Chalabi. Int Rev Neurobiol 2017
50
Adeno-associated virus-delivered artificial microRNA extends survival and delays paralysis in an amyotrophic lateral sclerosis mouse model.
Lorelei Stoica, Sophia H Todeasa, Gabriela Toro Cabrera, Johnny S Salameh, Mai K ElMallah, Christian Mueller, Robert H Brown, Miguel Sena-Esteves. Ann Neurol 2016
Lorelei Stoica, Sophia H Todeasa, Gabriela Toro Cabrera, Johnny S Salameh, Mai K ElMallah, Christian Mueller, Robert H Brown, Miguel Sena-Esteves. Ann Neurol 2016
50
Ataxin-2 gene: a powerful modulator of neurological disorders.
Jose Miguel Laffita-Mesa, Martin Paucar, Per Svenningsson. Curr Opin Neurol 2021
Jose Miguel Laffita-Mesa, Martin Paucar, Per Svenningsson. Curr Opin Neurol 2021
50
Novel optineurin mutations in patients with familial and sporadic amyotrophic lateral sclerosis.
R Del Bo, C Tiloca, V Pensato, L Corrado, A Ratti, N Ticozzi, S Corti, B Castellotti, L Mazzini, G Sorarù,[...]. J Neurol Neurosurg Psychiatry 2011
R Del Bo, C Tiloca, V Pensato, L Corrado, A Ratti, N Ticozzi, S Corti, B Castellotti, L Mazzini, G Sorarù,[...]. J Neurol Neurosurg Psychiatry 2011
50
A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group.
G Bensimon, L Lacomblez, V Meininger. N Engl J Med 1994
G Bensimon, L Lacomblez, V Meininger. N Engl J Med 1994
50
Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man.
Lindsey R Fischer, Deborah G Culver, Philip Tennant, Albert A Davis, Minsheng Wang, Amilcar Castellano-Sanchez, Jaffar Khan, Meraida A Polak, Jonathan D Glass. Exp Neurol 2004
Lindsey R Fischer, Deborah G Culver, Philip Tennant, Albert A Davis, Minsheng Wang, Amilcar Castellano-Sanchez, Jaffar Khan, Meraida A Polak, Jonathan D Glass. Exp Neurol 2004
50
Concise review: Stem cell therapies for amyotrophic lateral sclerosis: recent advances and prospects for the future.
J Simon Lunn, Stacey A Sakowski, Eva L Feldman. Stem Cells 2014
J Simon Lunn, Stacey A Sakowski, Eva L Feldman. Stem Cells 2014
50
Transplantation of spinal cord-derived neural stem cells for ALS: Analysis of phase 1 and 2 trials.
Jonathan D Glass, Vicki S Hertzberg, Nicholas M Boulis, Jonathan Riley, Thais Federici, Meraida Polak, Jane Bordeau, Christina Fournier, Karl Johe, Tom Hazel,[...]. Neurology 2016
Jonathan D Glass, Vicki S Hertzberg, Nicholas M Boulis, Jonathan Riley, Thais Federici, Meraida Polak, Jane Bordeau, Christina Fournier, Karl Johe, Tom Hazel,[...]. Neurology 2016
50
Edaravone, a Free Radical Scavenger, Delayed Symptomatic and Pathological Progression of Motor Neuron Disease in the Wobbler Mouse.
Ken Ikeda, Yasuo Iwasaki. PLoS One 2015
Ken Ikeda, Yasuo Iwasaki. PLoS One 2015
50
Edaravone (Radicava): A Novel Neuroprotective Agent for the Treatment of Amyotrophic Lateral Sclerosis.
Martin Paspe Cruz. P T 2018
Martin Paspe Cruz. P T 2018
50
Therapeutic AAV9-mediated suppression of mutant SOD1 slows disease progression and extends survival in models of inherited ALS.
Kevin D Foust, Desirée L Salazar, Shibi Likhite, Laura Ferraiuolo, Dara Ditsworth, Hristelina Ilieva, Kathrin Meyer, Leah Schmelzer, Lyndsey Braun, Don W Cleveland,[...]. Mol Ther 2013
Kevin D Foust, Desirée L Salazar, Shibi Likhite, Laura Ferraiuolo, Dara Ditsworth, Hristelina Ilieva, Kathrin Meyer, Leah Schmelzer, Lyndsey Braun, Don W Cleveland,[...]. Mol Ther 2013
50
Trial of Sodium Phenylbutyrate-Taurursodiol for Amyotrophic Lateral Sclerosis.
Sabrina Paganoni, Eric A Macklin, Suzanne Hendrix, James D Berry, Michael A Elliott, Samuel Maiser, Chafic Karam, James B Caress, Margaret A Owegi, Adam Quick,[...]. N Engl J Med 2020
Sabrina Paganoni, Eric A Macklin, Suzanne Hendrix, James D Berry, Michael A Elliott, Samuel Maiser, Chafic Karam, James B Caress, Margaret A Owegi, Adam Quick,[...]. N Engl J Med 2020
50
Confirmatory double-blind, parallel-group, placebo-controlled study of efficacy and safety of edaravone (MCI-186) in amyotrophic lateral sclerosis patients.
Koji Abe, Yasuto Itoyama, Gen Sobue, Shoji Tsuji, Masashi Aoki, Manabu Doyu, Chikuma Hamada, Kazuoki Kondo, Takatomo Yoneoka, Makoto Akimoto,[...]. Amyotroph Lateral Scler Frontotemporal Degener 2014
Koji Abe, Yasuto Itoyama, Gen Sobue, Shoji Tsuji, Masashi Aoki, Manabu Doyu, Chikuma Hamada, Kazuoki Kondo, Takatomo Yoneoka, Makoto Akimoto,[...]. Amyotroph Lateral Scler Frontotemporal Degener 2014
50
Enhanced Bulbar Function in Amyotrophic Lateral Sclerosis: The Nuedexta Treatment Trial.
Richard Smith, Erik Pioro, Kathleen Myers, Michael Sirdofsky, Kimberly Goslin, Gregg Meekins, Hong Yu, James Wymer, Merit Cudkowicz, Eric A Macklin,[...]. Neurotherapeutics 2017
Richard Smith, Erik Pioro, Kathleen Myers, Michael Sirdofsky, Kimberly Goslin, Gregg Meekins, Hong Yu, James Wymer, Merit Cudkowicz, Eric A Macklin,[...]. Neurotherapeutics 2017
50
The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis.
L Van Den Bosch, P Van Damme, E Bogaert, W Robberecht. Biochim Biophys Acta 2006
L Van Den Bosch, P Van Damme, E Bogaert, W Robberecht. Biochim Biophys Acta 2006
50
Antisense oligonucleotides: the next frontier for treatment of neurological disorders.
Carlo Rinaldi, Matthew J A Wood. Nat Rev Neurol 2018
Carlo Rinaldi, Matthew J A Wood. Nat Rev Neurol 2018
50
A proposal for new diagnostic criteria for ALS.
Jeremy M Shefner, Ammar Al-Chalabi, Mark R Baker, Li-Ying Cui, Mamede de Carvalho, Andrew Eisen, Julian Grosskreutz, Orla Hardiman, Robert Henderson, Jose Manuel Matamala,[...]. Clin Neurophysiol 2020
Jeremy M Shefner, Ammar Al-Chalabi, Mark R Baker, Li-Ying Cui, Mamede de Carvalho, Andrew Eisen, Julian Grosskreutz, Orla Hardiman, Robert Henderson, Jose Manuel Matamala,[...]. Clin Neurophysiol 2020
50
Analysis of survival and prognostic factors in amyotrophic lateral sclerosis: a population based study.
S Zoccolella, E Beghi, G Palagano, A Fraddosio, V Guerra, V Samarelli, V Lepore, I L Simone, P Lamberti, L Serlenga,[...]. J Neurol Neurosurg Psychiatry 2008
S Zoccolella, E Beghi, G Palagano, A Fraddosio, V Guerra, V Samarelli, V Lepore, I L Simone, P Lamberti, L Serlenga,[...]. J Neurol Neurosurg Psychiatry 2008
50
ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair.
Joseph R Klim, Luis A Williams, Francesco Limone, Irune Guerra San Juan, Brandi N Davis-Dusenbery, Daniel A Mordes, Aaron Burberry, Michael J Steinbaugh, Kanchana K Gamage, Rory Kirchner,[...]. Nat Neurosci 2019
Joseph R Klim, Luis A Williams, Francesco Limone, Irune Guerra San Juan, Brandi N Davis-Dusenbery, Daniel A Mordes, Aaron Burberry, Michael J Steinbaugh, Kanchana K Gamage, Rory Kirchner,[...]. Nat Neurosci 2019
50
Ibudilast (MN-166) in amyotrophic lateral sclerosis- an open label, safety and pharmacodynamic trial.
Suma Babu, Baileigh G Hightower, James Chan, Nicole R Zürcher, Pia Kivisäkk, Chieh-En J Tseng, Danica L Sanders, Ashley Robichaud, Haruhiko Banno, Armineuza Evora,[...]. Neuroimage Clin 2021
Suma Babu, Baileigh G Hightower, James Chan, Nicole R Zürcher, Pia Kivisäkk, Chieh-En J Tseng, Danica L Sanders, Ashley Robichaud, Haruhiko Banno, Armineuza Evora,[...]. Neuroimage Clin 2021
50
Sodium phenylbutyrate in Huntington's disease: a dose-finding study.
Penelope Hogarth, Luca Lovrecic, Dimitri Krainc. Mov Disord 2007
Penelope Hogarth, Luca Lovrecic, Dimitri Krainc. Mov Disord 2007
50
Phase 2 study of sodium phenylbutyrate in ALS.
Merit E Cudkowicz, Patricia L Andres, Sally A Macdonald, Richard S Bedlack, Rabia Choudry, Robert H Brown, Hui Zhang, David A Schoenfeld, Jeremy Shefner, Samantha Matson,[...]. Amyotroph Lateral Scler 2009
Merit E Cudkowicz, Patricia L Andres, Sally A Macdonald, Richard S Bedlack, Rabia Choudry, Robert H Brown, Hui Zhang, David A Schoenfeld, Jeremy Shefner, Samantha Matson,[...]. Amyotroph Lateral Scler 2009
50
Bioequivalence Study of Oral Suspension and Intravenous Formulation of Edaravone in Healthy Adult Subjects.
Hidetoshi Shimizu, Yukiko Nishimura, Youichi Shiide, Kaori Yoshida, Manabu Hirai, Munetomo Matsuda, Yoshinobu Nakamaru, Yuichiro Kato, Kazuoki Kondo. Clin Pharmacol Drug Dev 2021
Hidetoshi Shimizu, Yukiko Nishimura, Youichi Shiide, Kaori Yoshida, Manabu Hirai, Munetomo Matsuda, Yoshinobu Nakamaru, Yuichiro Kato, Kazuoki Kondo. Clin Pharmacol Drug Dev 2021
50
Riluzole 5 mg/mL oral suspension: for optimized drug delivery in amyotrophic lateral sclerosis.
Ann Margaret Dyer, Alan Smith. Drug Des Devel Ther 2016
Ann Margaret Dyer, Alan Smith. Drug Des Devel Ther 2016
50
UNC13A is a modifier of survival in amyotrophic lateral sclerosis.
Frank P Diekstra, Paul W J van Vught, Wouter van Rheenen, Max Koppers, R Jeroen Pasterkamp, Michael A van Es, Helenius J Schelhaas, Marianne de Visser, Wim Robberecht, Philip Van Damme,[...]. Neurobiol Aging 2012
Frank P Diekstra, Paul W J van Vught, Wouter van Rheenen, Max Koppers, R Jeroen Pasterkamp, Michael A van Es, Helenius J Schelhaas, Marianne de Visser, Wim Robberecht, Philip Van Damme,[...]. Neurobiol Aging 2012
50
Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: drug, nutritional, and respiratory therapies (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology.
R G Miller, C E Jackson, E J Kasarskis, J D England, D Forshew, W Johnston, S Kalra, J S Katz, H Mitsumoto, J Rosenfeld,[...]. Neurology 2009
R G Miller, C E Jackson, E J Kasarskis, J D England, D Forshew, W Johnston, S Kalra, J S Katz, H Mitsumoto, J Rosenfeld,[...]. Neurology 2009
50
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.