A citation-based method for searching scientific literature

R C Frederich, A Hamann, S Anderson, B Löllmann, B B Lowell, J S Flier. Nat Med 1995
Times Cited: 1291

List of co-cited articles
720 articles co-cited >1

Times Cited
  Times     Co-cited

Positional cloning of the mouse obese gene and its human homologue.
Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M Friedman. Nature 1994

Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects.
M Maffei, J Halaas, E Ravussin, R E Pratley, G H Lee, Y Zhang, H Fei, S Kim, R Lallone, S Ranganathan. Nat Med 1995

Weight-reducing effects of the plasma protein encoded by the obese gene.
J L Halaas, K S Gajiwala, M Maffei, S L Cohen, B T Chait, D Rabinowitz, R L Lallone, S K Burley, J M Friedman. Science 1995

Serum immunoreactive-leptin concentrations in normal-weight and obese humans.
R V Considine, M K Sinha, M L Heiman, A Kriauciunas, T W Stephens, M R Nyce, J P Ohannesian, C C Marco, L J McKee, T L Bauer. N Engl J Med 1996

Role of leptin in the neuroendocrine response to fasting.
R S Ahima, D Prabakaran, C Mantzoros, D Qu, B Lowell, E Maratos-Flier, J S Flier. Nature 1996

Identification and expression cloning of a leptin receptor, OB-R.
L A Tartaglia, M Dembski, X Weng, N Deng, J Culpepper, R Devos, G J Richards, L A Campfield, F T Clark, J Deeds,[...]. Cell 1995

Obesity is associated with hypothalamic injury in rodents and humans.
Joshua P Thaler, Chun-Xia Yi, Ellen A Schur, Stephan J Guyenet, Bang H Hwang, Marcelo O Dietrich, Xiaolin Zhao, David A Sarruf, Vitaly Izgur, Kenneth R Maravilla,[...]. J Clin Invest 2012

Congenital leptin deficiency is associated with severe early-onset obesity in humans.
C T Montague, I S Farooqi, J P Whitehead, M A Soos, H Rau, N J Wareham, C P Sewter, J E Digby, S N Mohammed, J A Hurst,[...]. Nature 1997

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus.
M A Cowley, J L Smart, M Rubinstein, M G Cerdán, S Diano, T L Horvath, R D Cone, M J Low. Nature 2001

Central nervous system control of food intake and body weight.
G J Morton, D E Cummings, D G Baskin, G S Barsh, M W Schwartz. Nature 2006

Obesity is associated with macrophage accumulation in adipose tissue.
Stuart P Weisberg, Daniel McCann, Manisha Desai, Michael Rosenbaum, Rudolph L Leibel, Anthony W Ferrante. J Clin Invest 2003

Leptin and the regulation of body weight in mammals.
J M Friedman, J L Halaas. Nature 1998

Activation of downstream signals by the long form of the leptin receptor.
A S Banks, S M Davis, S H Bates, M G Myers. J Biol Chem 2000

Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy.
Shangang Zhao, Yi Zhu, Robbie D Schultz, Na Li, Zhenyan He, Zhuzhen Zhang, Alexandre Caron, Qingzhang Zhu, Kai Sun, Wei Xiong,[...]. Cell Metab 2019

STAT3 signalling is required for leptin regulation of energy balance but not reproduction.
Sarah H Bates, Walter H Stearns, Trevor A Dundon, Markus Schubert, Annette W K Tso, Yongping Wang, Alexander S Banks, Hugh J Lavery, Asma K Haq, Eleftheria Maratos-Flier,[...]. Nature 2003

Central nervous system control of food intake.
M W Schwartz, S C Woods, D Porte, R J Seeley, D G Baskin. Nature 2000

Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity.
K El-Haschimi, D D Pierroz, S M Hileman, C Bjørbaek, J S Flier. J Clin Invest 2000

Ghrelin is a growth-hormone-releasing acylated peptide from stomach.
M Kojima, H Hosoda, Y Date, M Nakazato, H Matsuo, K Kangawa. Nature 1999

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction.
K Clément, C Vaisse, N Lahlou, S Cabrol, V Pelloux, D Cassuto, M Gourmelen, C Dina, J Chambaz, J M Lacorte,[...]. Nature 1998

Obesity and leptin resistance: distinguishing cause from effect.
Martin G Myers, Rudolph L Leibel, Randy J Seeley, Michael W Schwartz. Trends Endocrinol Metab 2010

Effects of the obese gene product on body weight regulation in ob/ob mice.
M A Pelleymounter, M J Cullen, M B Baker, R Hecht, D Winters, T Boone, F Collins. Science 1995

Hyperleptinemia is required for the development of leptin resistance.
Zachary A Knight, K Schot Hannan, Matthew L Greenberg, Jeffrey M Friedman. PLoS One 2010

Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans.
M W Schwartz, E Peskind, M Raskind, E J Boyko, D Porte. Nat Med 1996

Challenges and opportunities of defining clinical leptin resistance.
Martin G Myers, Steven B Heymsfield, Carol Haft, Barbara B Kahn, Maren Laughlin, Rudolph L Leibel, Matthias H Tschöp, Jack A Yanovski. Cell Metab 2012

Leptin targets in the mouse brain.
Michael M Scott, Jennifer L Lachey, Scott M Sternson, Charlotte E Lee, Carol F Elias, Jeffrey M Friedman, Joel K Elmquist. J Comp Neurol 2009

Mechanisms of leptin action and leptin resistance.
Martin G Myers, Michael A Cowley, Heike Münzberg. Annu Rev Physiol 2008

Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice.
C Vaisse, J L Halaas, C M Horvath, J E Darnell, M Stoffel, J M Friedman. Nat Genet 1996

Acute and long-term suppression of feeding behavior by POMC neurons in the brainstem and hypothalamus, respectively.
Cheng Zhan, Jingfeng Zhou, Qiru Feng, Ju-En Zhang, Shuailiang Lin, Junhong Bao, Ping Wu, Minmin Luo. J Neurosci 2013

Structure, production and signaling of leptin.
Heike Münzberg, Christopher D Morrison. Metabolism 2015

Effects of recombinant leptin therapy in a child with congenital leptin deficiency.
I S Farooqi, S A Jebb, G Langmack, E Lawrence, C H Cheetham, A M Prentice, I A Hughes, M A McCamish, S O'Rahilly. N Engl J Med 1999

Genetic identification of leptin neural circuits in energy and glucose homeostases.
Jie Xu, Christopher L Bartolome, Cho Shing Low, Xinchi Yi, Cheng-Hao Chien, Peng Wang, Dong Kong. Nature 2018

The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors.
H Baumann, K K Morella, D W White, M Dembski, P S Bailon, H Kim, C F Lai, L A Tartaglia. Proc Natl Acad Sci U S A 1996

Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis.
Nina Balthasar, Roberto Coppari, Julie McMinn, Shun M Liu, Charlotte E Lee, Vinsee Tang, Christopher D Kenny, Robert A McGovern, Streamson C Chua, Joel K Elmquist,[...]. Neuron 2004

Diabetes, a new mutation in the mouse.
K P Hummel, M M Dickie, D L Coleman. Science 1966

Leptin regulates striatal regions and human eating behavior.
I Sadaf Farooqi, Edward Bullmore, Julia Keogh, Jonathan Gillard, Stephen O'Rahilly, Paul C Fletcher. Science 2007

The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity.
Roberto Coppari, Masumi Ichinose, Charlotte E Lee, Abigail E Pullen, Christopher D Kenny, Robert A McGovern, Vinsee Tang, Shun M Liu, Thomas Ludwig, Streamson C Chua,[...]. Cell Metab 2005

Region-specific leptin resistance within the hypothalamus of diet-induced obese mice.
Heike Münzberg, Jeffrey S Flier, Christian Bjørbaek. Endocrinology 2004

Leptin signaling and leptin resistance.
Yingjiang Zhou, Liangyou Rui. Front Med 2013

Leptin: a review of its peripheral actions and interactions.
S Margetic, C Gazzola, G G Pegg, R A Hill. Int J Obes Relat Metab Disord 2002

Leptin secretion from subcutaneous and visceral adipose tissue in women.
V Van Harmelen, S Reynisdottir, P Eriksson, A Thörne, J Hoffstedt, F Lönnqvist, P Arner. Diabetes 1998

SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985.
C Bjorbak, H J Lavery, S H Bates, R K Olson, S M Davis, J S Flier, M G Myers. J Biol Chem 2000

Leptin-dependent control of glucose balance and locomotor activity by POMC neurons.
Lihong Huo, Kevin Gamber, Sarah Greeley, Jose Silva, Nicholas Huntoon, Xing-Hong Leng, Christian Bjørbaek. Cell Metab 2009

Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons.
Linh Vong, Chianping Ye, Zongfang Yang, Brian Choi, Streamson Chua, Bradford B Lowell. Neuron 2011

Ghrelin induces adiposity in rodents.
M Tschöp, D L Smiley, M L Heiman. Nature 2000

The hormone resistin links obesity to diabetes.
C M Steppan, S T Bailey, S Bhat, E J Brown, R R Banerjee, C M Wright, H R Patel, R S Ahima, M A Lazar. Nature 2001

Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.