A citation-based method for searching scientific literature

D M Sabatini, H Erdjument-Bromage, M Lui, P Tempst, S H Snyder. Cell 1994
Times Cited: 1110







List of co-cited articles
1231 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


A mammalian protein targeted by G1-arresting rapamycin-receptor complex.
E J Brown, M W Albers, T B Shin, K Ichikawa, C T Keith, W S Lane, S L Schreiber. Nature 1994
66


Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells.
C J Sabers, M M Martin, G J Brunn, J M Williams, F J Dumont, G Wiederrecht, R T Abraham. J Biol Chem 1995
633
37

mTOR Signaling in Growth, Metabolism, and Disease.
Robert A Saxton, David M Sabatini. Cell 2017
30

mTOR signaling in growth control and disease.
Mathieu Laplante, David M Sabatini. Cell 2012
27

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.
Do-Hyung Kim, D D Sarbassov, Siraj M Ali, Jessie E King, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Cell 2002
26

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.
Estela Jacinto, Robbie Loewith, Anja Schmidt, Shuo Lin, Markus A Rüegg, Alan Hall, Michael N Hall. Nat Cell Biol 2004
26

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.
D D Sarbassov, Siraj M Ali, Do-Hyung Kim, David A Guertin, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Curr Biol 2004
25

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.
Kenta Hara, Yoshiko Maruki, Xiaomeng Long, Ken-ichi Yoshino, Noriko Oshiro, Sujuti Hidayat, Chiharu Tokunaga, Joseph Avruch, Kazuyoshi Yonezawa. Cell 2002
25

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
Yasemin Sancak, Timothy R Peterson, Yoav D Shaul, Robert A Lindquist, Carson C Thoreen, Liron Bar-Peled, David M Sabatini. Science 2008
24

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.
Dos D Sarbassov, Siraj M Ali, Shomit Sengupta, Joon-Ho Sheen, Peggy P Hsu, Alex F Bagley, Andrew L Markhard, David M Sabatini. Mol Cell 2006
23

AMPK phosphorylation of raptor mediates a metabolic checkpoint.
Dana M Gwinn, David B Shackelford, Daniel F Egan, Maria M Mihaylova, Annabelle Mery, Debbie S Vasquez, Benjamin E Turk, Reuben J Shaw. Mol Cell 2008
22

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.
D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini. Science 2005
21

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
Yasemin Sancak, Liron Bar-Peled, Roberto Zoncu, Andrew L Markhard, Shigeyuki Nada, David M Sabatini. Cell 2010
21

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival.
Timothy R Peterson, Mathieu Laplante, Carson C Thoreen, Yasemin Sancak, Seong A Kang, W Michael Kuehl, Nathanael S Gray, David M Sabatini. Cell 2009
814
20


GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.
Do-Hyung Kim, D D Sarbassov, Siraj M Ali, Robert R Latek, Kalyani V P Guntur, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Mol Cell 2003
662
19

TOR signaling in growth and metabolism.
Stephan Wullschleger, Robbie Loewith, Michael N Hall. Cell 2006
18

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.
Robbie Loewith, Estela Jacinto, Stephan Wullschleger, Anja Lorberg, José L Crespo, Débora Bonenfant, Wolfgang Oppliger, Paul Jenoe, Michael N Hall. Mol Cell 2002
18

TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1.
Christian C Dibble, Winfried Elis, Suchithra Menon, Wei Qin, Justin Klekota, John M Asara, Peter M Finan, David J Kwiatkowski, Leon O Murphy, Brendan D Manning. Mol Cell 2012
368
18

Regulation of TORC1 by Rag GTPases in nutrient response.
Eunjung Kim, Pankuri Goraksha-Hicks, Li Li, Thomas P Neufeld, Kun-Liang Guan. Nat Cell Biol 2008
859
18

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.
Yasemin Sancak, Carson C Thoreen, Timothy R Peterson, Robert A Lindquist, Seong A Kang, Eric Spooner, Steven A Carr, David M Sabatini. Mol Cell 2007
862
18



TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.
Ken Inoki, Yong Li, Tianquan Zhu, Jun Wu, Kun-Liang Guan. Nat Cell Biol 2002
17

mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.
Timothy R Peterson, Shomit S Sengupta, Thurl E Harris, Anne E Carmack, Seong A Kang, Eric Balderas, David A Guertin, Katherine L Madden, Anne E Carpenter, Brian N Finck,[...]. Cell 2011
669
16

Activation of a metabolic gene regulatory network downstream of mTOR complex 1.
Katrin Düvel, Jessica L Yecies, Suchithra Menon, Pichai Raman, Alex I Lipovsky, Amanda L Souza, Ellen Triantafellow, Qicheng Ma, Regina Gorski, Stephen Cleaver,[...]. Mol Cell 2010
16

Rheb binds and regulates the mTOR kinase.
Xiaomeng Long, Yenshou Lin, Sara Ortiz-Vega, Kazuyoshi Yonezawa, Joseph Avruch. Curr Biol 2005
660
16

Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.
Issam Ben-Sahra, Jessica J Howell, John M Asara, Brendan D Manning. Science 2013
396
16

mTOR kinase structure, mechanism and regulation.
Haijuan Yang, Derek G Rudge, Joseph D Koos, Bhamini Vaidialingam, Hyo J Yang, Nikola P Pavletich. Nature 2013
521
16


mTOR Signaling in Growth, Metabolism, and Disease.
Robert A Saxton, David M Sabatini. Cell 2017
844
15

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.
Liron Bar-Peled, Lynne Chantranupong, Andrew D Cherniack, Walter W Chen, Kathleen A Ottina, Brian C Grabiner, Eric D Spear, Scott L Carter, Matthew Meyerson, David M Sabatini. Science 2013
563
15

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.
Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan. Nat Cell Biol 2011
15

Identification of Protor as a novel Rictor-binding component of mTOR complex-2.
Laura R Pearce, Xu Huang, Jérôme Boudeau, Rafał Pawłowski, Stephan Wullschleger, Maria Deak, Adel F M Ibrahim, Robert Gourlay, Mark A Magnuson, Dario R Alessi. Biochem J 2007
307
15

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression.
J Kunz, R Henriquez, U Schneider, M Deuter-Reinhard, N R Movva, M N Hall. Cell 1993
676
14

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.
David A Guertin, Deanna M Stevens, Carson C Thoreen, Aurora A Burds, Nada Y Kalaany, Jason Moffat, Michael Brown, Kevin J Fitzgerald, David M Sabatini. Dev Cell 2006
14

Inhibition of the immune response by rapamycin, a new antifungal antibiotic.
R R Martel, J Klicius, S Galet. Can J Physiol Pharmacol 1977
328
14

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.
Estela Jacinto, Valeria Facchinetti, Dou Liu, Nelyn Soto, Shiniu Wei, Sung Yun Jung, Qiaojia Huang, Jun Qin, Bing Su. Cell 2006
14

SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway.
Xin Gu, Jose M Orozco, Robert A Saxton, Kendall J Condon, Grace Y Liu, Patrycja A Krawczyk, Sonia M Scaria, J Wade Harper, Steven P Gygi, David M Sabatini. Science 2017
191
14

The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif.
Hiroki Nojima, Chiharu Tokunaga, Satoshi Eguchi, Noriko Oshiro, Sujuti Hidayat, Ken-ichi Yoshino, Kenta Hara, Noriaki Tanaka, Joseph Avruch, Kazuyoshi Yonezawa. J Biol Chem 2003
456
14

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s.
Maria A Frias, Carson C Thoreen, Jacob D Jaffe, Wayne Schroder, Tom Sculley, Steven A Carr, David M Sabatini. Curr Biol 2006
482
14

The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.
Zhi-Yang Tsun, Liron Bar-Peled, Lynne Chantranupong, Roberto Zoncu, Tim Wang, Choah Kim, Eric Spooner, David M Sabatini. Mol Cell 2013
305
14

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway.
Lynne Chantranupong, Sonia M Scaria, Robert A Saxton, Melanie P Gygi, Kuang Shen, Gregory A Wyant, Tim Wang, J Wade Harper, Steven P Gygi, David M Sabatini. Cell 2016
353
14

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.
Manuele Rebsamen, Lorena Pochini, Taras Stasyk, Mariana E G de Araújo, Michele Galluccio, Richard K Kandasamy, Berend Snijder, Astrid Fauster, Elena L Rudashevskaya, Manuela Bruckner,[...]. Nature 2015
377
14


Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40.
Emilie Vander Haar, Seong-Il Lee, Sricharan Bandhakavi, Timothy J Griffin, Do-Hyung Kim. Nat Cell Biol 2007
815
13

mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex.
John T Cunningham, Joseph T Rodgers, Daniel H Arlow, Francisca Vazquez, Vamsi K Mootha, Pere Puigserver. Nature 2007
926
13

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.
Rachel L Wolfson, Lynne Chantranupong, Gregory A Wyant, Xin Gu, Jose M Orozco, Kuang Shen, Kendall J Condon, Sabrina Petri, Jibril Kedir, Sonia M Scaria,[...]. Nature 2017
126
13

Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.
Liron Bar-Peled, Lawrence D Schweitzer, Roberto Zoncu, David M Sabatini. Cell 2012
560
13


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.