A citation-based method for searching scientific literature

S Zeitlin, J P Liu, D L Chapman, V E Papaioannou, A Efstratiadis. Nat Genet 1995
Times Cited: 548







List of co-cited articles
1323 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes.
J Nasir, S B Floresco, J R O'Kusky, V M Diewert, J M Richman, J Zeisler, A Borowski, J D Marth, A G Phillips, M R Hayden. Cell 1995
581
71

Inactivation of the mouse Huntington's disease gene homolog Hdh.
M P Duyao, A B Auerbach, A Ryan, F Persichetti, G T Barnes, S M McNeil, P Ge, J P Vonsattel, J F Gusella, A L Joyner. Science 1995
485
60


The Biology of Huntingtin.
Frédéric Saudou, Sandrine Humbert. Neuron 2016
328
42


Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis.
Holly B Kordasiewicz, Lisa M Stanek, Edward V Wancewicz, Curt Mazur, Melissa M McAlonis, Kimberly A Pytel, Jonathan W Artates, Andreas Weiss, Seng H Cheng, Lamya S Shihabuddin,[...]. Neuron 2012
438
27

Ablation of huntingtin in adult neurons is nondeleterious but its depletion in young mice causes acute pancreatitis.
Guohao Wang, Xudong Liu, Marta A Gaertig, Shihua Li, Xiao-Jiang Li. Proc Natl Acad Sci U S A 2016
69
39

Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules.
Laurent R Gauthier, Bénédicte C Charrin, Maria Borrell-Pagès, Jim P Dompierre, Hélène Rangone, Fabrice P Cordelières, Jan De Mey, Marcy E MacDonald, Volkmar Lessmann, Sandrine Humbert,[...]. Cell 2004
769
25

Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion.
J K White, W Auerbach, M P Duyao, J P Vonsattel, J F Gusella, A L Joyner, M E MacDonald. Nat Genet 1997
365
24

Huntington disease.
Gillian P Bates, Ray Dorsey, James F Gusella, Michael R Hayden, Chris Kay, Blair R Leavitt, Martha Nance, Christopher A Ross, Rachael I Scahill, Ronald Wetzel,[...]. Nat Rev Dis Primers 2015
522
20

Wild-type huntingtin protects from apoptosis upstream of caspase-3.
D Rigamonti, J H Bauer, C De-Fraja, L Conti, S Sipione, C Sciorati, E Clementi, A Hackam, M R Hayden, Y Li,[...]. J Neurosci 2000
264
19

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.
M DiFiglia, E Sapp, K O Chase, S W Davies, G P Bates, J P Vonsattel, N Aronin. Science 1997
19

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.
J S Steffan, A Kazantsev, O Spasic-Boskovic, M Greenwald, Y Z Zhu, H Gohler, E E Wanker, G P Bates, D E Housman, L M Thompson. Proc Natl Acad Sci U S A 2000
775
19

Huntington's disease: from molecular pathogenesis to clinical treatment.
Christopher A Ross, Sarah J Tabrizi. Lancet Neurol 2011
868
19

Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis.
Juliette D Godin, Kelly Colombo, Maria Molina-Calavita, Guy Keryer, Diana Zala, Bénédicte C Charrin, Paula Dietrich, Marie-Laure Volvert, François Guillemot, Ioannis Dragatsis,[...]. Neuron 2010
168
19

Potential function for the Huntingtin protein as a scaffold for selective autophagy.
Joseph Ochaba, Tamás Lukacsovich, George Csikos, Shuqiu Zheng, Julia Margulis, Lisa Salazar, Kai Mao, Alice L Lau, Sylvia Y Yeung, Sandrine Humbert,[...]. Proc Natl Acad Sci U S A 2014
152
18

Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease.
C Zuccato, A Ciammola, D Rigamonti, B R Leavitt, D Goffredo, L Conti, M E MacDonald, R M Friedlander, V Silani, M R Hayden,[...]. Science 2001
910
18

Huntingtin is required for normal excitatory synapse development in cortical and striatal circuits.
Spencer U McKinstry, Yonca B Karadeniz, Atesh K Worthington, Volodya Y Hayrapetyan, M Ilcim Ozlu, Karol Serafin-Molina, W Christopher Risher, Tuna Ustunkaya, Ioannis Dragatsis, Scott Zeitlin,[...]. J Neurosci 2014
70
25


Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes.
Chiara Zuccato, Marzia Tartari, Andrea Crotti, Donato Goffredo, Marta Valenza, Luciano Conti, Tiziana Cataudella, Blair R Leavitt, Michael R Hayden, Tõnis Timmusk,[...]. Nat Genet 2003
635
17

Huntingtin functions as a scaffold for selective macroautophagy.
Yan-Ning Rui, Zhen Xu, Bindi Patel, Zhihua Chen, Dongsheng Chen, Antonio Tito, Gabriela David, Yamin Sun, Erin F Stimming, Hugo J Bellen,[...]. Nat Cell Biol 2015
220
16

Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease.
Kirupa Sathasivam, Andreas Neueder, Theresa A Gipson, Christian Landles, Agnesska C Benjamin, Marie K Bondulich, Donna L Smith, Richard L M Faull, Raymund A C Roos, David Howland,[...]. Proc Natl Acad Sci U S A 2013
252
16

Targeting Huntingtin Expression in Patients with Huntington's Disease.
Sarah J Tabrizi, Blair R Leavitt, G Bernhard Landwehrmeyer, Edward J Wild, Carsten Saft, Roger A Barker, Nick F Blair, David Craufurd, Josef Priller, Hugh Rickards,[...]. N Engl J Med 2019
225
16

Huntingtin facilitates dynein/dynactin-mediated vesicle transport.
Juliane P Caviston, Jennifer L Ross, Sheila M Antony, Mariko Tokito, Erika L F Holzbaur. Proc Natl Acad Sci U S A 2007
191
15

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation.
S W Davies, M Turmaine, B A Cozens, M DiFiglia, A H Sharp, C A Ross, E Scherzinger, E E Wanker, L Mangiarini, G P Bates. Cell 1997
15

Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons.
M DiFiglia, E Sapp, K Chase, C Schwarz, A Meloni, C Young, E Martin, J P Vonsattel, R Carraway, S A Reeves. Neuron 1995
559
15

Permanent inactivation of Huntington's disease mutation by personalized allele-specific CRISPR/Cas9.
Jun Wan Shin, Kyung-Hee Kim, Michael J Chao, Ranjit S Atwal, Tammy Gillis, Marcy E MacDonald, James F Gusella, Jong-Min Lee. Hum Mol Genet 2016
118
15

Normal huntingtin function: an alternative approach to Huntington's disease.
Elena Cattaneo, Chiara Zuccato, Marzia Tartari. Nat Rev Neurosci 2005
426
14

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death.
Montserrat Arrasate, Siddhartha Mitra, Erik S Schweitzer, Mark R Segal, Steven Finkbeiner. Nature 2004
14

Mutant Huntingtin alters retrograde transport of TrkB receptors in striatal dendrites.
Géraldine Liot, Diana Zala, Patrick Pla, Guillaume Mottet, Matthieu Piel, Frédéric Saudou. J Neurosci 2013
103
14

Network organization of the huntingtin proteomic interactome in mammalian brain.
Dyna I Shirasaki, Erin R Greiner, Ismael Al-Ramahi, Michelle Gray, Pinmanee Boontheung, Daniel H Geschwind, Juan Botas, Giovanni Coppola, Steve Horvath, Joseph A Loo,[...]. Neuron 2012
164
14

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.
Rona K Graham, Yu Deng, Elizabeth J Slow, Brendan Haigh, Nagat Bissada, Ge Lu, Jacqueline Pearson, Jacqueline Shehadeh, Lisa Bertram, Zoe Murphy,[...]. Cell 2006
460
14

CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion.
J-M Lee, E M Ramos, J-H Lee, T Gillis, J S Mysore, M R Hayden, S C Warby, P Morrison, M Nance, C A Ross,[...]. Neurology 2012
184
14

Sustained effects of nonallele-specific Huntingtin silencing.
Valérie Drouet, Valérie Perrin, Raymonde Hassig, Noëlle Dufour, Gwennaelle Auregan, Sandro Alves, Gilles Bonvento, Emmanuel Brouillet, Ruth Luthi-Carter, Philippe Hantraye,[...]. Ann Neurol 2009
161
14

Preclinical safety of RNAi-mediated HTT suppression in the rhesus macaque as a potential therapy for Huntington's disease.
Jodi L McBride, Mark R Pitzer, Ryan L Boudreau, Brett Dufour, Theodore Hobbs, Sergio R Ojeda, Beverly L Davidson. Mol Ther 2011
148
14

Six-month partial suppression of Huntingtin is well tolerated in the adult rhesus striatum.
Richard Grondin, Michael D Kaytor, Yi Ai, Peter T Nelson, Deepak R Thakker, Jennifer Heisel, Marcy R Weatherspoon, Janelle L Blum, Eric N Burright, Zhiming Zhang,[...]. Brain 2012
96
14

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice.
L Mangiarini, K Sathasivam, M Seller, B Cozens, A Harper, C Hetherington, M Lawton, Y Trottier, H Lehrach, S W Davies,[...]. Cell 1996
14

Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington's disease mice.
Ryan L Boudreau, Jodi L McBride, Inês Martins, Shihao Shen, Yi Xing, Barrie J Carter, Beverly L Davidson. Mol Ther 2009
238
14

Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits.
M DiFiglia, M Sena-Esteves, K Chase, E Sapp, E Pfister, M Sass, J Yoder, P Reeves, R K Pandey, K G Rajeev,[...]. Proc Natl Acad Sci U S A 2007
283
14


Huntingtin facilitates polycomb repressive complex 2.
Ihn Sik Seong, Juliana M Woda, Ji-Joon Song, Alejandro Lloret, Priyanka D Abeyrathne, Caroline J Woo, Gillian Gregory, Jong-Min Lee, Vanessa C Wheeler, Thomas Walz,[...]. Hum Mol Genet 2010
105
13

The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease.
S E Andrew, Y P Goldberg, B Kremer, H Telenius, J Theilmann, S Adam, E Starr, F Squitieri, B Lin, M A Kalchman. Nat Genet 1993
785
12


Postnatal and adult consequences of loss of huntingtin during development: Implications for Huntington's disease.
Eduardo E Arteaga-Bracho, Maria Gulinello, Michael L Winchester, Nandini Pichamoorthy, Jenna R Petronglo, Alicia D Zambrano, Julio Inocencio, Chirstopher D De Jesus, Joseph O Louie, Solen Gokhan,[...]. Neurobiol Dis 2016
32
37

Structure and expression of the Huntington's disease gene: evidence against simple inactivation due to an expanded CAG repeat.
Christine M Ambrose, Mabel P Duyao, Glenn Barnes, Gillian P Bates, Carol S Lin, Jayalakshmi Srinidhi, Sarah Baxendale, Holger Hummerich, Hans Lehrach, Michael Altherr,[...]. Somat Cell Mol Genet 1994
202
12

Measures of growth in children at risk for Huntington disease.
Jessica K Lee, Kathy Mathews, Bradley Schlaggar, Joel Perlmutter, Jane S Paulsen, Eric Epping, Leon Burmeister, Peg Nopoulos. Neurology 2012
51
21

Huntington disease: natural history, biomarkers and prospects for therapeutics.
Christopher A Ross, Elizabeth H Aylward, Edward J Wild, Douglas R Langbehn, Jeffrey D Long, John H Warner, Rachael I Scahill, Blair R Leavitt, Julie C Stout, Jane S Paulsen,[...]. Nat Rev Neurol 2014
501
11

Trinucleotide repeat length instability and age of onset in Huntington's disease.
M Duyao, C Ambrose, R Myers, A Novelletto, F Persichetti, M Frontali, S Folstein, C Ross, M Franz, M Abbott. Nat Genet 1993
801
11

Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons.
Emilie Colin, Diana Zala, Géraldine Liot, Hélène Rangone, Maria Borrell-Pagès, Xiao-Jiang Li, Frédéric Saudou, Sandrine Humbert. EMBO J 2008
223
11

Phylogenetic comparison of huntingtin homologues reveals the appearance of a primitive polyQ in sea urchin.
Marzia Tartari, Carmela Gissi, Valentina Lo Sardo, Chiara Zuccato, Ernesto Picardi, Graziano Pesole, Elena Cattaneo. Mol Biol Evol 2008
57
19


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.