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Times Cited: 99
Times Cited: 99
Times Cited
Times Co-cited
Similarity
Structure of human factor VIII.
G A Vehar, B Keyt, D Eaton, H Rodriguez, D P O'Brien, F Rotblat, H Oppermann, R Keck, W I Wood, R N Harkins,[...]. Nature 1984
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A large region (approximately equal to 95 kDa) of human factor VIII is dispensable for in vitro procoagulant activity.
J J Toole, D D Pittman, E C Orr, P Murtha, L C Wasley, R J Kaufman. Proc Natl Acad Sci U S A 1986
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Biochemical, immunological, and in vivo functional characterization of B-domain-deleted factor VIII.
D D Pittman, E M Alderman, K N Tomkinson, J H Wang, A R Giles, R J Kaufman. Blood 1993
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Molecular cloning of a cDNA encoding human antihaemophilic factor.
J J Toole, J L Knopf, J M Wozney, L A Sultzman, J L Buecker, D D Pittman, R J Kaufman, E Brown, C Shoemaker, E C Orr. Nature 1984
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Synthesis, processing, and secretion of recombinant human factor VIII expressed in mammalian cells.
R J Kaufman, L C Wasley, A J Dorner. J Biol Chem 1988
R J Kaufman, L C Wasley, A J Dorner. J Biol Chem 1988
20
Long-term safety and efficacy of factor IX gene therapy in hemophilia B.
Amit C Nathwani, Ulreke M Reiss, Edward G D Tuddenham, Cecilia Rosales, Pratima Chowdary, Jenny McIntosh, Marco Della Peruta, Elsa Lheriteau, Nishal Patel, Deepak Raj,[...]. N Engl J Med 2014
Amit C Nathwani, Ulreke M Reiss, Edward G D Tuddenham, Cecilia Rosales, Pratima Chowdary, Jenny McIntosh, Marco Della Peruta, Elsa Lheriteau, Nishal Patel, Deepak Raj,[...]. N Engl J Med 2014
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Characterization of the human factor VIII gene.
J Gitschier, W I Wood, T M Goralka, K L Wion, E Y Chen, D H Eaton, G A Vehar, D J Capon, R M Lawn. Nature 1984
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Structural and functional characteristics of the B-domain-deleted recombinant factor VIII protein, r-VIII SQ.
H Sandberg, A Almstedt, J Brandt, E Gray, L Holmquist, U Oswaldsson, S Sebring, M Mikaelsson. Thromb Haemost 2001
H Sandberg, A Almstedt, J Brandt, E Gray, L Holmquist, U Oswaldsson, S Sebring, M Mikaelsson. Thromb Haemost 2001
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Adenovirus-associated virus vector-mediated gene transfer in hemophilia B.
Amit C Nathwani, Edward G D Tuddenham, Savita Rangarajan, Cecilia Rosales, Jenny McIntosh, David C Linch, Pratima Chowdary, Anne Riddell, Arnulfo Jaquilmac Pie, Chris Harrington,[...]. N Engl J Med 2011
Amit C Nathwani, Edward G D Tuddenham, Savita Rangarajan, Cecilia Rosales, Jenny McIntosh, David C Linch, Pratima Chowdary, Anne Riddell, Arnulfo Jaquilmac Pie, Chris Harrington,[...]. N Engl J Med 2011
17
Construction and characterization of an active factor VIII variant lacking the central one-third of the molecule.
D L Eaton, W I Wood, D Eaton, P E Hass, P Hollingshead, K Wion, J Mather, R M Lawn, G A Vehar, C Gorman. Biochemistry 1986
D L Eaton, W I Wood, D Eaton, P E Hass, P Hollingshead, K Wion, J Mather, R M Lawn, G A Vehar, C Gorman. Biochemistry 1986
16
Isolation and characterization of human factor VIII: molecular forms in commercial factor VIII concentrate, cryoprecipitate, and plasma.
L O Andersson, N Forsman, K Huang, K Larsen, A Lundin, B Pavlu, H Sandberg, K Sewerin, J Smart. Proc Natl Acad Sci U S A 1986
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15
Role of the B domain for factor VIII and factor V expression and function.
D D Pittman, K A Marquette, R J Kaufman. Blood 1994
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24
The life cycle of coagulation factor VIII in view of its structure and function.
P J Lenting, J A van Mourik, K Mertens. Blood 1998
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15
Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant.
Jenny McIntosh, Peter J Lenting, Cecilia Rosales, Doyoung Lee, Samira Rabbanian, Deepak Raj, Nishil Patel, Edward G D Tuddenham, Olivier D Christophe, John H McVey,[...]. Blood 2013
Jenny McIntosh, Peter J Lenting, Cecilia Rosales, Doyoung Lee, Samira Rabbanian, Deepak Raj, Nishil Patel, Edward G D Tuddenham, Olivier D Christophe, John H McVey,[...]. Blood 2013
15
Sequences in the coding region of clotting factor VIII act as dominant inhibitors of RNA accumulation and protein production.
C M Lynch, D I Israel, R J Kaufman, A D Miller. Hum Gene Ther 1993
C M Lynch, D I Israel, R J Kaufman, A D Miller. Hum Gene Ther 1993
14
Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response.
Catherine S Manno, Glenn F Pierce, Valder R Arruda, Bertil Glader, Margaret Ragni, John J Rasko, Margareth C Ozelo, Keith Hoots, Philip Blatt, Barbara Konkle,[...]. Nat Med 2006
Catherine S Manno, Glenn F Pierce, Valder R Arruda, Bertil Glader, Margaret Ragni, John J Rasko, Margareth C Ozelo, Keith Hoots, Philip Blatt, Barbara Konkle,[...]. Nat Med 2006
14
Expression of active human factor VIII from recombinant DNA clones.
W I Wood, D J Capon, C C Simonsen, D L Eaton, J Gitschier, B Keyt, P H Seeburg, D H Smith, P Hollingshead, K L Wion,[...]. Nature 1984
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13
High level expression of recombinant porcine coagulation factor VIII.
Christopher B Doering, John F Healey, Ernest T Parker, Rachel T Barrow, Pete Lollar. J Biol Chem 2002
Christopher B Doering, John F Healey, Ernest T Parker, Rachel T Barrow, Pete Lollar. J Biol Chem 2002
16
AAV liver expression of FIX-Padua prevents and eradicates FIX inhibitor without increasing thrombogenicity in hemophilia B dogs and mice.
Julie M Crudele, Jonathan D Finn, Joshua I Siner, Nicholas B Martin, Glenn P Niemeyer, Shangzhen Zhou, Federico Mingozzi, Clinton D Lothrop, Valder R Arruda. Blood 2015
Julie M Crudele, Jonathan D Finn, Joshua I Siner, Nicholas B Martin, Glenn P Niemeyer, Shangzhen Zhou, Federico Mingozzi, Clinton D Lothrop, Valder R Arruda. Blood 2015
13
X-linked thrombophilia with a mutant factor IX (factor IX Padua).
Paolo Simioni, Daniela Tormene, Giulio Tognin, Sabrina Gavasso, Cristiana Bulato, Nicholas P Iacobelli, Jonathan D Finn, Luca Spiezia, Claudia Radu, Valder R Arruda. N Engl J Med 2009
Paolo Simioni, Daniela Tormene, Giulio Tognin, Sabrina Gavasso, Cristiana Bulato, Nicholas P Iacobelli, Jonathan D Finn, Luca Spiezia, Claudia Radu, Valder R Arruda. N Engl J Med 2009
12
Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant.
Lindsey A George, Spencer K Sullivan, Adam Giermasz, John E J Rasko, Benjamin J Samelson-Jones, Jonathan Ducore, Adam Cuker, Lisa M Sullivan, Suvankar Majumdar, Jerome Teitel,[...]. N Engl J Med 2017
Lindsey A George, Spencer K Sullivan, Adam Giermasz, John E J Rasko, Benjamin J Samelson-Jones, Jonathan Ducore, Adam Cuker, Lisa M Sullivan, Suvankar Majumdar, Jerome Teitel,[...]. N Engl J Med 2017
12
AAV5-Factor VIII Gene Transfer in Severe Hemophilia A.
Savita Rangarajan, Liron Walsh, Will Lester, David Perry, Bella Madan, Michael Laffan, Hua Yu, Christian Vettermann, Glenn F Pierce, Wing Y Wong,[...]. N Engl J Med 2017
Savita Rangarajan, Liron Walsh, Will Lester, David Perry, Bella Madan, Michael Laffan, Hua Yu, Christian Vettermann, Glenn F Pierce, Wing Y Wong,[...]. N Engl J Med 2017
12
Biosynthesis, assembly and secretion of coagulation factor VIII.
R J Kaufman, S W Pipe, L Tagliavacca, M Swaroop, M Moussalli. Blood Coagul Fibrinolysis 1997
R J Kaufman, S W Pipe, L Tagliavacca, M Swaroop, M Moussalli. Blood Coagul Fibrinolysis 1997
16
Effect of von Willebrand factor coexpression on the synthesis and secretion of factor VIII in Chinese hamster ovary cells.
R J Kaufman, L C Wasley, M V Davies, R J Wise, D I Israel, A J Dorner. Mol Cell Biol 1989
R J Kaufman, L C Wasley, M V Davies, R J Wise, D I Israel, A J Dorner. Mol Cell Biol 1989
11
Post-translational requirements for functional factor V and factor VIII secretion in mammalian cells.
D D Pittman, K N Tomkinson, R J Kaufman. J Biol Chem 1994
D D Pittman, K N Tomkinson, R J Kaufman. J Biol Chem 1994
13
Expression of the blood-clotting factor-VIII cDNA is repressed by a transcriptional silencer located in its coding region.
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15
Differential interaction of coagulation factor VIII and factor V with protein chaperones calnexin and calreticulin.
S W Pipe, J A Morris, J Shah, R J Kaufman. J Biol Chem 1998
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11
Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A.
L Bi, A M Lawler, S E Antonarakis, K A High, J D Gearhart, H H Kazazian. Nat Genet 1995
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11
Gene therapy with adeno-associated virus vector 5-human factor IX in adults with hemophilia B.
Wolfgang Miesbach, Karina Meijer, Michiel Coppens, Peter Kampmann, Robert Klamroth, Roger Schutgens, Marco Tangelder, Giancarlo Castaman, Joachim Schwäble, Halvard Bonig,[...]. Blood 2018
Wolfgang Miesbach, Karina Meijer, Michiel Coppens, Peter Kampmann, Robert Klamroth, Roger Schutgens, Marco Tangelder, Giancarlo Castaman, Joachim Schwäble, Halvard Bonig,[...]. Blood 2018
11
Proteolytic processing of human factor VIII. Correlation of specific cleavages by thrombin, factor Xa, and activated protein C with activation and inactivation of factor VIII coagulant activity.
D Eaton, H Rodriguez, G A Vehar. Biochemistry 1986
D Eaton, H Rodriguez, G A Vehar. Biochemistry 1986
10
Development of freeze-dried albumin-free formulation of recombinant factor VIII SQ.
T Osterberg, A Fatouros, M Mikaelsson. Pharm Res 1997
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19
Long-term expression of human coagulation factor VIII and correction of hemophilia A after in vivo retroviral gene transfer in factor VIII-deficient mice.
T VandenDriessche, V Vanslembrouck, I Goovaerts, H Zwinnen, M L Vanderhaeghen, D Collen, M K Chuah. Proc Natl Acad Sci U S A 1999
T VandenDriessche, V Vanslembrouck, I Goovaerts, H Zwinnen, M L Vanderhaeghen, D Collen, M K Chuah. Proc Natl Acad Sci U S A 1999
10
Human factor VIIIa subunit structure. Reconstruction of factor VIIIa from the isolated A1/A3-C1-C2 dimer and A2 subunit.
P J Fay, P J Haidaris, T M Smudzin. J Biol Chem 1991
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Purified human factor VIII procoagulant protein: comparative hemostatic response after infusions into hemophilic and von Willebrand disease dogs.
K M Brinkhous, H Sandberg, J B Garris, C Mattsson, M Palm, T Griggs, M S Read. Proc Natl Acad Sci U S A 1985
K M Brinkhous, H Sandberg, J B Garris, C Mattsson, M Palm, T Griggs, M S Read. Proc Natl Acad Sci U S A 1985
10
Antigenicity of putative phospholipid membrane-binding residues in factor VIII.
R T Barrow, J F Healey, M G Jacquemin, J M Saint-Remy, P Lollar. Blood 2001
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16
Induction of immune tolerance to coagulation factor IX antigen by in vivo hepatic gene transfer.
Federico Mingozzi, Yi-Lin Liu, Eric Dobrzynski, Antje Kaufhold, Jian Hua Liu, YuQin Wang, Valder R Arruda, Katherine A High, Roland W Herzog. J Clin Invest 2003
Federico Mingozzi, Yi-Lin Liu, Eric Dobrzynski, Antje Kaufhold, Jian Hua Liu, YuQin Wang, Valder R Arruda, Katherine A High, Roland W Herzog. J Clin Invest 2003
10
The tertiary structure and domain organization of coagulation factor VIII.
Betty W Shen, Paul Clint Spiegel, Chong-Hwan Chang, Jae-Wook Huh, Jung-Sik Lee, Jeanman Kim, Young-Ho Kim, Barry L Stoddard. Blood 2008
Betty W Shen, Paul Clint Spiegel, Chong-Hwan Chang, Jae-Wook Huh, Jung-Sik Lee, Jeanman Kim, Young-Ho Kim, Barry L Stoddard. Blood 2008
10
Eradication of neutralizing antibodies to factor VIII in canine hemophilia A after liver gene therapy.
Jonathan D Finn, Margareth C Ozelo, Denise E Sabatino, Helen W G Franck, Elizabeth P Merricks, Julie M Crudele, Shangzhen Zhou, Haig H Kazazian, David Lillicrap, Timothy C Nichols,[...]. Blood 2010
Jonathan D Finn, Margareth C Ozelo, Denise E Sabatino, Helen W G Franck, Elizabeth P Merricks, Julie M Crudele, Shangzhen Zhou, Haig H Kazazian, David Lillicrap, Timothy C Nichols,[...]. Blood 2010
10
The efficacy and the risk of immunogenicity of FIX Padua (R338L) in hemophilia B dogs treated by AAV muscle gene therapy.
Jonathan D Finn, Timothy C Nichols, Nikolaos Svoronos, Elizabeth P Merricks, Dwight A Bellenger, Shangshen Zhou, Paolo Simioni, Katherine A High, Valder R Arruda. Blood 2012
Jonathan D Finn, Timothy C Nichols, Nikolaos Svoronos, Elizabeth P Merricks, Dwight A Bellenger, Shangshen Zhou, Paolo Simioni, Katherine A High, Valder R Arruda. Blood 2012
13
Reduction of the antigenicity of factor VIII toward complex inhibitory antibody plasmas using multiply-substituted hybrid human/porcine factor VIII molecules.
R T Barrow, J F Healey, D Gailani, D Scandella, P Lollar. Blood 2000
R T Barrow, J F Healey, D Gailani, D Scandella, P Lollar. Blood 2000
10
Residues Glu2181-Val2243 contain a major determinant of the inhibitory epitope in the C2 domain of human factor VIII.
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J F Healey, R T Barrow, H M Tamim, I M Lubin, M Shima, D Scandella, P Lollar. Blood 1998
10
Human recombinant DNA-derived antihemophilic factor (factor VIII) in the treatment of hemophilia A. recombinant Factor VIII Study Group.
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9
pH-dependent denaturation of thrombin-activated porcine factor VIII.
P Lollar, C G Parker. J Biol Chem 1990
P Lollar, C G Parker. J Biol Chem 1990
9
Structural basis for the decreased procoagulant activity of human factor VIII compared to the porcine homolog.
P Lollar, E T Parker. J Biol Chem 1991
P Lollar, E T Parker. J Biol Chem 1991
9
Bioengineering of coagulation factor VIII for improved secretion.
Hongzhi Z Miao, Nongnuch Sirachainan, Lisa Palmer, Phillip Kucab, Michael A Cunningham, Randal J Kaufman, Steven W Pipe. Blood 2004
Hongzhi Z Miao, Nongnuch Sirachainan, Lisa Palmer, Phillip Kucab, Michael A Cunningham, Randal J Kaufman, Steven W Pipe. Blood 2004
9
Minimal modification in the factor VIII B-domain sequence ameliorates the murine hemophilia A phenotype.
Joshua I Siner, Nicholas P Iacobelli, Denise E Sabatino, Lacramiora Ivanciu, Shangzhen Zhou, Mortimer Poncz, Rodney M Camire, Valder R Arruda. Blood 2013
Joshua I Siner, Nicholas P Iacobelli, Denise E Sabatino, Lacramiora Ivanciu, Shangzhen Zhou, Mortimer Poncz, Rodney M Camire, Valder R Arruda. Blood 2013
16
Employing a gain-of-function factor IX variant R338L to advance the efficacy and safety of hemophilia B human gene therapy: preclinical evaluation supporting an ongoing adeno-associated virus clinical trial.
Paul E Monahan, Junjiang Sun, Tong Gui, Genlin Hu, William B Hannah, David G Wichlan, Zhijian Wu, Joshua C Grieger, Chengwen Li, Thipparat Suwanmanee,[...]. Hum Gene Ther 2015
Paul E Monahan, Junjiang Sun, Tong Gui, Genlin Hu, William B Hannah, David G Wichlan, Zhijian Wu, Joshua C Grieger, Chengwen Li, Thipparat Suwanmanee,[...]. Hum Gene Ther 2015
12
Platelet-targeted gene therapy with human factor VIII establishes haemostasis in dogs with haemophilia A.
Lily M Du, Paquita Nurden, Alan T Nurden, Timothy C Nichols, Dwight A Bellinger, Eric S Jensen, Sandra L Haberichter, Elizabeth Merricks, Robin A Raymer, Juan Fang,[...]. Nat Commun 2013
Lily M Du, Paquita Nurden, Alan T Nurden, Timothy C Nichols, Dwight A Bellinger, Eric S Jensen, Sandra L Haberichter, Elizabeth Merricks, Robin A Raymer, Juan Fang,[...]. Nat Commun 2013
11
Emicizumab Prophylaxis in Hemophilia A with Inhibitors.
Johannes Oldenburg, Johnny N Mahlangu, Benjamin Kim, Christophe Schmitt, Michael U Callaghan, Guy Young, Elena Santagostino, Rebecca Kruse-Jarres, Claude Negrier, Craig Kessler,[...]. N Engl J Med 2017
Johannes Oldenburg, Johnny N Mahlangu, Benjamin Kim, Christophe Schmitt, Michael U Callaghan, Guy Young, Elena Santagostino, Rebecca Kruse-Jarres, Claude Negrier, Craig Kessler,[...]. N Engl J Med 2017
9
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.