I Matsuo, S Kuratani, C Kimura, N Takeda, S Aizawa. Genes Dev 1995
Times Cited: 561
Times Cited: 561
Times Cited
Times Co-cited
Similarity
Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation.
D Acampora, S Mazan, Y Lallemand, V Avantaggiato, M Maury, A Simeone, P Brûlet. Development 1995
D Acampora, S Mazan, Y Lallemand, V Avantaggiato, M Maury, A Simeone, P Brûlet. Development 1995
42
A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain.
S L Ang, O Jin, M Rhinn, N Daigle, L Stevenson, J Rossant. Development 1996
S L Ang, O Jin, M Rhinn, N Daigle, L Stevenson, J Rossant. Development 1996
23
Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development.
Akihiro Nishida, Akiko Furukawa, Chieko Koike, Yasuo Tano, Shinichi Aizawa, Isao Matsuo, Takahisa Furukawa. Nat Neurosci 2003
Akihiro Nishida, Akiko Furukawa, Chieko Koike, Yasuo Tano, Shinichi Aizawa, Isao Matsuo, Takahisa Furukawa. Nat Neurosci 2003
20
Heterozygous mutations of OTX2 cause severe ocular malformations.
Nicola K Ragge, Alison G Brown, Charlotte M Poloschek, Birgit Lorenz, R Alex Henderson, Michael P Clarke, Isabelle Russell-Eggitt, Alistair Fielder, Dianne Gerrelli, Juan Pedro Martinez-Barbera,[...]. Am J Hum Genet 2005
Nicola K Ragge, Alison G Brown, Charlotte M Poloschek, Birgit Lorenz, R Alex Henderson, Michael P Clarke, Isabelle Russell-Eggitt, Alistair Fielder, Dianne Gerrelli, Juan Pedro Martinez-Barbera,[...]. Am J Hum Genet 2005
17
20
Novel heterozygous OTX2 mutations and whole gene deletions in anophthalmia, microphthalmia and coloboma.
Alexander Wyatt, Preeti Bakrania, David J Bunyan, Robert J Osborne, John A Crolla, Alison Salt, Carmen Ayuso, Ruth Newbury-Ecob, Y Abou-Rayyah, J Richard O Collin,[...]. Hum Mutat 2008
Alexander Wyatt, Preeti Bakrania, David J Bunyan, Robert J Osborne, John A Crolla, Alison Salt, Carmen Ayuso, Ruth Newbury-Ecob, Y Abou-Rayyah, J Richard O Collin,[...]. Hum Mutat 2008
17
A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo.
A Simeone, D Acampora, A Mallamaci, A Stornaiuolo, M R D'Apice, V Nigro, E Boncinelli. EMBO J 1993
A Simeone, D Acampora, A Mallamaci, A Stornaiuolo, M R D'Apice, V Nigro, E Boncinelli. EMBO J 1993
12
OTX2 microphthalmia syndrome: four novel mutations and delineation of a phenotype.
K F Schilter, A Schneider, T Bardakjian, J-F Soucy, R C Tyler, L M Reis, E V Semina. Clin Genet 2011
K F Schilter, A Schneider, T Bardakjian, J-F Soucy, R C Tyler, L M Reis, E V Semina. Clin Genet 2011
16
Nested expression domains of four homeobox genes in developing rostral brain.
A Simeone, D Acampora, M Gulisano, A Stornaiuolo, E Boncinelli. Nature 1992
A Simeone, D Acampora, M Gulisano, A Stornaiuolo, E Boncinelli. Nature 1992
11
Genetic modifiers of otocephalic phenotypes in Otx2 heterozygous mutant mice.
Takuichiro Hide, Jun Hatakeyama, Chiharu Kimura-Yoshida, E Tian, Naoki Takeda, Yukitaka Ushio, Toshihiko Shiroishi, Shinichi Aizawa, Isao Matsuo. Development 2002
Takuichiro Hide, Jun Hatakeyama, Chiharu Kimura-Yoshida, E Tian, Naoki Takeda, Yukitaka Ushio, Toshihiko Shiroishi, Shinichi Aizawa, Isao Matsuo. Development 2002
19
Otx genes are required for tissue specification in the developing eye.
J R Martinez-Morales, M Signore, D Acampora, A Simeone, P Bovolenta. Development 2001
J R Martinez-Morales, M Signore, D Acampora, A Simeone, P Bovolenta. Development 2001
9
Functional roles of Otx2 transcription factor in postnatal mouse retinal development.
Chieko Koike, Akihiro Nishida, Shinji Ueno, Hiromitsu Saito, Rikako Sanuki, Shigeru Sato, Akiko Furukawa, Shinichi Aizawa, Isao Matsuo, Noboru Suzuki,[...]. Mol Cell Biol 2007
Chieko Koike, Akihiro Nishida, Shinji Ueno, Hiromitsu Saito, Rikako Sanuki, Shigeru Sato, Akiko Furukawa, Shinichi Aizawa, Isao Matsuo, Noboru Suzuki,[...]. Mol Cell Biol 2007
9
A novel dominant negative mutation of OTX2 associated with combined pituitary hormone deficiency.
Daniel Diaczok, Christopher Romero, Janice Zunich, Ian Marshall, Sally Radovick. J Clin Endocrinol Metab 2008
Daniel Diaczok, Christopher Romero, Janice Zunich, Ian Marshall, Sally Radovick. J Clin Endocrinol Metab 2008
11
Temporal and spatial delineation of mouse Otx2 functions by conditional self-knockout.
Nicolas Fossat, Gilles Chatelain, Gilbert Brun, Thomas Lamonerie. EMBO Rep 2006
Nicolas Fossat, Gilles Chatelain, Gilbert Brun, Thomas Lamonerie. EMBO Rep 2006
20
OTX2 mutations contribute to the otocephaly-dysgnathia complex.
Nicolas Chassaing, Susanna Sorrentino, Erica E Davis, Dominique Martin-Coignard, Anthony Iacovelli, William Paznekas, Bryn D Webb, Ona Faye-Petersen, Férechté Encha-Razavi, Leopoldine Lequeux,[...]. J Med Genet 2012
Nicolas Chassaing, Susanna Sorrentino, Erica E Davis, Dominique Martin-Coignard, Anthony Iacovelli, William Paznekas, Bryn D Webb, Ona Faye-Petersen, Férechté Encha-Razavi, Leopoldine Lequeux,[...]. J Med Genet 2012
22
The Rx homeobox gene is essential for vertebrate eye development.
P H Mathers, A Grinberg, K A Mahon, M Jamrich. Nature 1997
P H Mathers, A Grinberg, K A Mahon, M Jamrich. Nature 1997
9
Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse.
M T Dattani, J P Martinez-Barbera, P Q Thomas, J M Brickman, R Gupta, I L Mårtensson, H Toresson, M Fox, J K Wales, P C Hindmarsh,[...]. Nat Genet 1998
M T Dattani, J P Martinez-Barbera, P Q Thomas, J M Brickman, R Gupta, I L Mårtensson, H Toresson, M Fox, J K Wales, P C Hindmarsh,[...]. Nat Genet 1998
9
The caudal limit of Otx2 expression positions the isthmic organizer.
V Broccoli, E Boncinelli, W Wurst. Nature 1999
V Broccoli, E Boncinelli, W Wurst. Nature 1999
8
OTX2 loss of function mutation causes anophthalmia and combined pituitary hormone deficiency with a small anterior and ectopic posterior pituitary.
Toshihiro Tajima, Akira Ohtake, Masaya Hoshino, Shin Amemiya, Nozomu Sasaki, Katsura Ishizu, Kenji Fujieda. J Clin Endocrinol Metab 2009
Toshihiro Tajima, Akira Ohtake, Masaya Hoshino, Shin Amemiya, Nozomu Sasaki, Katsura Ishizu, Kenji Fujieda. J Clin Endocrinol Metab 2009
12
A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizer.
S Millet, K Campbell, D J Epstein, K Losos, E Harris, A L Joyner. Nature 1999
S Millet, K Campbell, D J Epstein, K Losos, E Harris, A L Joyner. Nature 1999
8
Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development.
Oleg V Lagutin, Changqi C Zhu, Daisuke Kobayashi, Jacek Topczewski, Kenji Shimamura, Luis Puelles, Helen R C Russell, Peter J McKinnon, Lilianna Solnica-Krezel, Guillermo Oliver. Genes Dev 2003
Oleg V Lagutin, Changqi C Zhu, Daisuke Kobayashi, Jacek Topczewski, Kenji Shimamura, Luis Puelles, Helen R C Russell, Peter J McKinnon, Lilianna Solnica-Krezel, Guillermo Oliver. Genes Dev 2003
8
Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm explants.
S L Ang, R A Conlon, O Jin, J Rossant. Development 1994
S L Ang, R A Conlon, O Jin, J Rossant. Development 1994
7
Interaction between Otx2 and Gbx2 defines the organizing center for the optic tectum.
T Katahira, T Sato, S Sugiyama, T Okafuji, I Araki, J Funahashi, H Nakamura. Mech Dev 2000
T Katahira, T Sato, S Sugiyama, T Okafuji, I Araki, J Funahashi, H Nakamura. Mech Dev 2000
7
OTX2 activates the molecular network underlying retina pigment epithelium differentiation.
Juan Ramón Martínez-Morales, Vincent Dolez, Isabel Rodrigo, Raffaella Zaccarini, Laurence Leconte, Paola Bovolenta, Simon Saule. J Biol Chem 2003
Juan Ramón Martínez-Morales, Vincent Dolez, Isabel Rodrigo, Raffaella Zaccarini, Laurence Leconte, Paola Bovolenta, Simon Saule. J Biol Chem 2003
7
A novel loss-of-function mutation in OTX2 in a patient with anophthalmia and isolated growth hormone deficiency.
Liat Ashkenazi-Hoffnung, Yael Lebenthal, Alexander W Wyatt, Nicola K Ragge, Sumito Dateki, Maki Fukami, Tsutomu Ogata, Moshe Phillip, Galia Gat-Yablonski. Hum Genet 2010
Liat Ashkenazi-Hoffnung, Yael Lebenthal, Alexander W Wyatt, Nicola K Ragge, Sumito Dateki, Maki Fukami, Tsutomu Ogata, Moshe Phillip, Galia Gat-Yablonski. Hum Genet 2010
22
Pax-6, a murine paired box gene, is expressed in the developing CNS.
C Walther, P Gruss. Development 1991
C Walther, P Gruss. Development 1991
7
Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation.
M Burmeister, J Novak, M Y Liang, S Basu, L Ploder, N L Hawes, D Vidgen, F Hoover, D Goldman, V I Kalnins,[...]. Nat Genet 1996
M Burmeister, J Novak, M Y Liang, S Basu, L Ploder, N L Hawes, D Vidgen, F Hoover, D Goldman, V I Kalnins,[...]. Nat Genet 1996
7
Vax1, a novel homeobox-containing gene, directs development of the basal forebrain and visual system.
M Hallonet, T Hollemann, T Pieler, P Gruss. Genes Dev 1999
M Hallonet, T Hollemann, T Pieler, P Gruss. Genes Dev 1999
7
Heterozygous orthodenticle homeobox 2 mutations are associated with variable pituitary phenotype.
Sumito Dateki, Kitaro Kosaka, Kosei Hasegawa, Hiroyuki Tanaka, Noriyuki Azuma, Susumu Yokoya, Koji Muroya, Masanori Adachi, Toshihiro Tajima, Katsuaki Motomura,[...]. J Clin Endocrinol Metab 2010
Sumito Dateki, Kitaro Kosaka, Kosei Hasegawa, Hiroyuki Tanaka, Noriyuki Azuma, Susumu Yokoya, Koji Muroya, Masanori Adachi, Toshihiro Tajima, Katsuaki Motomura,[...]. J Clin Endocrinol Metab 2010
9
A rare de novo nonsense mutation in OTX2 causes early onset retinal dystrophy and pituitary dysfunction.
Robert H Henderson, Kathleen A Williamson, Joanna S Kennedy, Andrew R Webster, Graham E Holder, Anthony G Robson, David R FitzPatrick, Veronica van Heyningen, Anthony T Moore. Mol Vis 2009
Robert H Henderson, Kathleen A Williamson, Joanna S Kennedy, Andrew R Webster, Graham E Holder, Anthony G Robson, David R FitzPatrick, Veronica van Heyningen, Anthony T Moore. Mol Vis 2009
14
Implication of OTX2 in pigment epithelium determination and neural retina differentiation.
P Bovolenta, A Mallamaci, P Briata, G Corte, E Boncinelli. J Neurosci 1997
P Bovolenta, A Mallamaci, P Briata, G Corte, E Boncinelli. J Neurosci 1997
7
Otx2 is an intrinsic determinant of the embryonic stem cell state and is required for transition to a stable epiblast stem cell condition.
Dario Acampora, Luca G Di Giovannantonio, Antonio Simeone. Development 2013
Dario Acampora, Luca G Di Giovannantonio, Antonio Simeone. Development 2013
6
Visceral endoderm mediates forebrain development by suppressing posteriorizing signals.
C Kimura, K Yoshinaga, E Tian, M Suzuki, S Aizawa, I Matsuo. Dev Biol 2000
C Kimura, K Yoshinaga, E Tian, M Suzuki, S Aizawa, I Matsuo. Dev Biol 2000
6
Mutations in BMP4 cause eye, brain, and digit developmental anomalies: overlap between the BMP4 and hedgehog signaling pathways.
Preeti Bakrania, Maria Efthymiou, Johannes C Klein, Alison Salt, David J Bunyan, Alex Wyatt, Chris P Ponting, Angela Martin, Steven Williams, Victoria Lindley,[...]. Am J Hum Genet 2008
Preeti Bakrania, Maria Efthymiou, Johannes C Klein, Alison Salt, David J Bunyan, Alex Wyatt, Chris P Ponting, Angela Martin, Steven Williams, Victoria Lindley,[...]. Am J Hum Genet 2008
6
OTX2 directly activates cell cycle genes and inhibits differentiation in medulloblastoma cells.
Jens Bunt, Nancy E Hasselt, Danny A Zwijnenburg, Mohamed Hamdi, Jan Koster, Rogier Versteeg, Marcel Kool. Int J Cancer 2012
Jens Bunt, Nancy E Hasselt, Danny A Zwijnenburg, Mohamed Hamdi, Jan Koster, Rogier Versteeg, Marcel Kool. Int J Cancer 2012
10
The Xenopus homologue of Otx2 is a maternal homeobox gene that demarcates and specifies anterior body regions.
M Pannese, C Polo, M Andreazzoli, R Vignali, B Kablar, G Barsacchi, E Boncinelli. Development 1995
M Pannese, C Polo, M Andreazzoli, R Vignali, B Kablar, G Barsacchi, E Boncinelli. Development 1995
6
Mutations in the human RAX homeobox gene in a patient with anophthalmia and sclerocornea.
Vera A Voronina, Elena A Kozhemyakina, Christina M O'Kernick, Natan D Kahn, Sharon L Wenger, John V Linberg, Adele S Schneider, Peter H Mathers. Hum Mol Genet 2004
Vera A Voronina, Elena A Kozhemyakina, Christina M O'Kernick, Natan D Kahn, Sharon L Wenger, John V Linberg, Adele S Schneider, Peter H Mathers. Hum Mol Genet 2004
6
Mouse small eye results from mutations in a paired-like homeobox-containing gene.
R E Hill, J Favor, B L Hogan, C C Ton, G F Saunders, I M Hanson, J Prosser, T Jordan, N D Hastie, V van Heyningen. Nature 1991
R E Hill, J Favor, B L Hogan, C C Ton, G F Saunders, I M Hanson, J Prosser, T Jordan, N D Hastie, V van Heyningen. Nature 1991
6
Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development.
F D Porter, J Drago, Y Xu, S S Cheema, C Wassif, S P Huang, E Lee, A Grinberg, J S Massalas, D Bodine,[...]. Development 1997
F D Porter, J Drago, Y Xu, S S Cheema, C Wassif, S P Huang, E Lee, A Grinberg, J S Massalas, D Bodine,[...]. Development 1997
6
Specification of the vertebrate eye by a network of eye field transcription factors.
Michael E Zuber, Gaia Gestri, Andrea S Viczian, Giuseppina Barsacchi, William A Harris. Development 2003
Michael E Zuber, Gaia Gestri, Andrea S Viczian, Giuseppina Barsacchi, William A Harris. Development 2003
6
Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function.
K M Wassarman, M Lewandoski, K Campbell, A L Joyner, J L Rubenstein, S Martinez, G R Martin. Development 1997
K M Wassarman, M Lewandoski, K Campbell, A L Joyner, J L Rubenstein, S Martinez, G R Martin. Development 1997
6
Crx, a novel otx-like homeobox gene, shows photoreceptor-specific expression and regulates photoreceptor differentiation.
T Furukawa, E M Morrow, C L Cepko. Cell 1997
T Furukawa, E M Morrow, C L Cepko. Cell 1997
6
Molecular mechanisms of cranial neural crest cell migration and patterning in craniofacial development.
Maryline Minoux, Filippo M Rijli. Development 2010
Maryline Minoux, Filippo M Rijli. Development 2010
6
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.
C Chiang, Y Litingtung, E Lee, K E Young, J L Corden, H Westphal, P A Beachy. Nature 1996
C Chiang, Y Litingtung, E Lee, K E Young, J L Corden, H Westphal, P A Beachy. Nature 1996
6
Deletion of OTX2 in neural ectoderm delays anterior pituitary development.
Amanda H Mortensen, Vanessa Schade, Thomas Lamonerie, Sally A Camper. Hum Mol Genet 2015
Amanda H Mortensen, Vanessa Schade, Thomas Lamonerie, Sally A Camper. Hum Mol Genet 2015
20
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling.
Stuart M Chambers, Christopher A Fasano, Eirini P Papapetrou, Mark Tomishima, Michel Sadelain, Lorenz Studer. Nat Biotechnol 2009
Stuart M Chambers, Christopher A Fasano, Eirini P Papapetrou, Mark Tomishima, Michel Sadelain, Lorenz Studer. Nat Biotechnol 2009
5
Regulation of Otx2 expression and its functions in mouse forebrain and midbrain.
Daisuke Kurokawa, Hiroshi Kiyonari, Rika Nakayama, Chiharu Kimura-Yoshida, Isao Matsuo, Shinichi Aizawa. Development 2004
Daisuke Kurokawa, Hiroshi Kiyonari, Rika Nakayama, Chiharu Kimura-Yoshida, Isao Matsuo, Shinichi Aizawa. Development 2004
6
The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain.
A P McMahon, A Bradley. Cell 1990
A P McMahon, A Bradley. Cell 1990
5
Otx2 gene deletion in adult mouse retina induces rapid RPE dystrophy and slow photoreceptor degeneration.
Francis Béby, Michael Housset, Nicolas Fossat, Coralie Le Greneur, Frédéric Flamant, Pierre Godement, Thomas Lamonerie. PLoS One 2010
Francis Béby, Michael Housset, Nicolas Fossat, Coralie Le Greneur, Frédéric Flamant, Pierre Godement, Thomas Lamonerie. PLoS One 2010
13
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.