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Times Cited: 394
Times Cited: 394
Times Cited
Times Co-cited
Similarity
The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases.
T N Stitt, G Conn, M Gore, C Lai, J Bruno, C Radziejewski, K Mattsson, J Fisher, D R Gies, P F Jones. Cell 1995
T N Stitt, G Conn, M Gore, C Lai, J Bruno, C Radziejewski, K Mattsson, J Fisher, D R Gies, P F Jones. Cell 1995
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The TAM family: phosphatidylserine sensing receptor tyrosine kinases gone awry in cancer.
Douglas K Graham, Deborah DeRyckere, Kurtis D Davies, H Shelton Earp. Nat Rev Cancer 2014
Douglas K Graham, Deborah DeRyckere, Kurtis D Davies, H Shelton Earp. Nat Rev Cancer 2014
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R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer.
Sacha J Holland, Alison Pan, Christian Franci, Yuanming Hu, Betty Chang, Weiqun Li, Matt Duan, Allan Torneros, Jiaxin Yu, Thilo J Heckrodt,[...]. Cancer Res 2010
Sacha J Holland, Alison Pan, Christian Franci, Yuanming Hu, Betty Chang, Weiqun Li, Matt Duan, Allan Torneros, Jiaxin Yu, Thilo J Heckrodt,[...]. Cancer Res 2010
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Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases.
K Nagata, K Ohashi, T Nakano, H Arita, C Zong, H Hanafusa, K Mizuno. J Biol Chem 1996
K Nagata, K Ohashi, T Nakano, H Arita, C Zong, H Hanafusa, K Mizuno. J Biol Chem 1996
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The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade.
G Manfioletti, C Brancolini, G Avanzi, C Schneider. Mol Cell Biol 1993
G Manfioletti, C Brancolini, G Avanzi, C Schneider. Mol Cell Biol 1993
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TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer.
Rachel M A Linger, Amy K Keating, H Shelton Earp, Douglas K Graham. Adv Cancer Res 2008
Rachel M A Linger, Amy K Keating, H Shelton Earp, Douglas K Graham. Adv Cancer Res 2008
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Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival.
Christine Gjerdrum, Crina Tiron, Torill Høiby, Ingunn Stefansson, Hallvard Haugen, Tone Sandal, Karin Collett, Shan Li, Emmet McCormack, Bjørn Tore Gjertsen,[...]. Proc Natl Acad Sci U S A 2010
Christine Gjerdrum, Crina Tiron, Torill Høiby, Ingunn Stefansson, Hallvard Haugen, Tone Sandal, Karin Collett, Shan Li, Emmet McCormack, Bjørn Tore Gjertsen,[...]. Proc Natl Acad Sci U S A 2010
26
axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase.
J P O'Bryan, R A Frye, P C Cogswell, A Neubauer, B Kitch, C Prokop, R Espinosa, M M Le Beau, H S Earp, E T Liu. Mol Cell Biol 1991
J P O'Bryan, R A Frye, P C Cogswell, A Neubauer, B Kitch, C Prokop, R Espinosa, M M Le Beau, H S Earp, E T Liu. Mol Cell Biol 1991
26
Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer.
Zhenfeng Zhang, Jae Cheol Lee, Luping Lin, Victor Olivas, Valerie Au, Thomas LaFramboise, Mohamed Abdel-Rahman, Xiaoqi Wang, Alan D Levine, Jin Kyung Rho,[...]. Nat Genet 2012
Zhenfeng Zhang, Jae Cheol Lee, Luping Lin, Victor Olivas, Valerie Au, Thomas LaFramboise, Mohamed Abdel-Rahman, Xiaoqi Wang, Alan D Levine, Jin Kyung Rho,[...]. Nat Genet 2012
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TAM receptors are pleiotropic inhibitors of the innate immune response.
Carla V Rothlin, Sourav Ghosh, Elina I Zuniga, Michael B A Oldstone, Greg Lemke. Cell 2007
Carla V Rothlin, Sourav Ghosh, Elina I Zuniga, Michael B A Oldstone, Greg Lemke. Cell 2007
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The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells.
Magdalena Paolino, Axel Choidas, Stephanie Wallner, Blanka Pranjic, Iris Uribesalgo, Stefanie Loeser, Amanda M Jamieson, Wallace Y Langdon, Fumiyo Ikeda, Juan Pablo Fededa,[...]. Nature 2014
Magdalena Paolino, Axel Choidas, Stephanie Wallner, Blanka Pranjic, Iris Uribesalgo, Stefanie Loeser, Amanda M Jamieson, Wallace Y Langdon, Fumiyo Ikeda, Juan Pablo Fededa,[...]. Nature 2014
24
Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family.
Q Lu, G Lemke. Science 2001
Q Lu, G Lemke. Science 2001
23
An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies.
X Ye, Y Li, S Stawicki, S Couto, J Eastham-Anderson, D Kallop, R Weimer, Y Wu, L Pei. Oncogene 2010
X Ye, Y Li, S Stawicki, S Couto, J Eastham-Anderson, D Kallop, R Weimer, Y Wu, L Pei. Oncogene 2010
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Structural basis for Gas6-Axl signalling.
Takako Sasaki, Pjotr G Knyazev, Naomi J Clout, Yuri Cheburkin, Walter Göhring, Axel Ullrich, Rupert Timpl, Erhard Hohenester. EMBO J 2006
Takako Sasaki, Pjotr G Knyazev, Naomi J Clout, Yuri Cheburkin, Walter Göhring, Axel Ullrich, Rupert Timpl, Erhard Hohenester. EMBO J 2006
21
Gas6 induces proliferation in prostate carcinoma cell lines expressing the Axl receptor.
Pier Paolo Sainaghi, Luigi Castello, Luca Bergamasco, Margherita Galletti, Paola Bellosta, Gian Carlo Avanzi. J Cell Physiol 2005
Pier Paolo Sainaghi, Luigi Castello, Luca Bergamasco, Margherita Galletti, Paola Bellosta, Gian Carlo Avanzi. J Cell Physiol 2005
18
Phagocytosis and clearance of apoptotic cells is mediated by MER.
R S Scott, E J McMahon, S M Pop, E A Reap, R Caricchio, P L Cohen, H S Earp, G K Matsushima. Nature 2001
R S Scott, E J McMahon, S M Pop, E A Reap, R Caricchio, P L Cohen, H S Earp, G K Matsushima. Nature 2001
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Axl as a potential therapeutic target in cancer: role of Axl in tumor growth, metastasis and angiogenesis.
Y Li, X Ye, C Tan, J-A Hongo, J Zha, J Liu, D Kallop, M J C Ludlam, L Pei. Oncogene 2009
Y Li, X Ye, C Tan, J-A Hongo, J Zha, J Liu, D Kallop, M J C Ludlam, L Pei. Oncogene 2009
18
Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities.
Erin D Lew, Jennifer Oh, Patrick G Burrola, Irit Lax, Anna Zagórska, Paqui G Través, Joseph Schlessinger, Greg Lemke. Elife 2014
Erin D Lew, Jennifer Oh, Patrick G Burrola, Irit Lax, Anna Zagórska, Paqui G Través, Joseph Schlessinger, Greg Lemke. Elife 2014
18
The receptor AXL diversifies EGFR signaling and limits the response to EGFR-targeted inhibitors in triple-negative breast cancer cells.
Aaron S Meyer, Miles A Miller, Frank B Gertler, Douglas A Lauffenburger. Sci Signal 2013
Aaron S Meyer, Miles A Miller, Frank B Gertler, Douglas A Lauffenburger. Sci Signal 2013
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Receptor tyrosine kinase AXL is induced by chemotherapy drugs and overexpression of AXL confers drug resistance in acute myeloid leukemia.
Chih-Chen Hong, Jong-Ding Lay, Jhy-Shrian Huang, Ann-Lii Cheng, Jih-Luh Tang, Ming-Tseh Lin, Gi-Ming Lai, Shuang-En Chuang. Cancer Lett 2008
Chih-Chen Hong, Jong-Ding Lay, Jhy-Shrian Huang, Ann-Lii Cheng, Jih-Luh Tang, Ming-Tseh Lin, Gi-Ming Lai, Shuang-En Chuang. Cancer Lett 2008
17
Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: activation of AXL.
Li Liu, James Greger, Hong Shi, Yuan Liu, Joel Greshock, Roland Annan, Wendy Halsey, Ganesh M Sathe, Anne-Marie Martin, Tona M Gilmer. Cancer Res 2009
Li Liu, James Greger, Hong Shi, Yuan Liu, Joel Greshock, Roland Annan, Wendy Halsey, Ganesh M Sathe, Anne-Marie Martin, Tona M Gilmer. Cancer Res 2009
17
AXL is a potential target for therapeutic intervention in breast cancer progression.
Yi-Xiang Zhang, Peter G Knyazev, Yuri V Cheburkin, Kirti Sharma, Yuri P Knyazev, László Orfi, István Szabadkai, Henrik Daub, György Kéri, Axel Ullrich. Cancer Res 2008
Yi-Xiang Zhang, Peter G Knyazev, Yuri V Cheburkin, Kirti Sharma, Yuri P Knyazev, László Orfi, István Szabadkai, Henrik Daub, György Kéri, Axel Ullrich. Cancer Res 2008
17
An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance.
Lauren Averett Byers, Lixia Diao, Jing Wang, Pierre Saintigny, Luc Girard, Michael Peyton, Li Shen, Youhong Fan, Uma Giri, Praveen K Tumula,[...]. Clin Cancer Res 2013
Lauren Averett Byers, Lixia Diao, Jing Wang, Pierre Saintigny, Luc Girard, Michael Peyton, Li Shen, Youhong Fan, Uma Giri, Praveen K Tumula,[...]. Clin Cancer Res 2013
17
Receptor tyrosine kinases, TYRO3, AXL, and MER, demonstrate distinct patterns and complex regulation of ligand-induced activation.
Wen-I Tsou, Khanh-Quynh N Nguyen, Daniel A Calarese, Scott J Garforth, Anita L Antes, Sergey V Smirnov, Steve C Almo, Raymond B Birge, Sergei V Kotenko. J Biol Chem 2014
Wen-I Tsou, Khanh-Quynh N Nguyen, Daniel A Calarese, Scott J Garforth, Anita L Antes, Sergey V Smirnov, Steve C Almo, Raymond B Birge, Sergei V Kotenko. J Biol Chem 2014
17
AXL Inhibitors in Cancer: A Medicinal Chemistry Perspective.
Samuel H Myers, Valerie G Brunton, Asier Unciti-Broceta. J Med Chem 2016
Samuel H Myers, Valerie G Brunton, Asier Unciti-Broceta. J Med Chem 2016
17
Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival.
Peter Vajkoczy, Pjotr Knyazev, Andrea Kunkel, Hans-Holger Capelle, Sandra Behrndt, Hendrik von Tengg-Kobligk, Fabian Kiessling, Uta Eichelsbacher, Marco Essig, Tracy-Ann Read,[...]. Proc Natl Acad Sci U S A 2006
Peter Vajkoczy, Pjotr Knyazev, Andrea Kunkel, Hans-Holger Capelle, Sandra Behrndt, Hendrik von Tengg-Kobligk, Fabian Kiessling, Uta Eichelsbacher, Marco Essig, Tracy-Ann Read,[...]. Proc Natl Acad Sci U S A 2006
16
The Axl receptor tyrosine kinase confers an adverse prognostic influence in pancreatic cancer and represents a new therapeutic target.
Jan-Bart M Koorstra, Collins A Karikari, Georg Feldmann, Savita Bisht, Pamela Leal Rojas, G Johan A Offerhaus, Hector Alvarez, Anirban Maitra. Cancer Biol Ther 2009
Jan-Bart M Koorstra, Collins A Karikari, Georg Feldmann, Savita Bisht, Pamela Leal Rojas, G Johan A Offerhaus, Hector Alvarez, Anirban Maitra. Cancer Biol Ther 2009
16
Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site.
J Braunger, L Schleithoff, A S Schulz, H Kessler, R Lammers, A Ullrich, C R Bartram, J W Janssen. Oncogene 1997
J Braunger, L Schleithoff, A S Schulz, H Kessler, R Lammers, A Ullrich, C R Bartram, J W Janssen. Oncogene 1997
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Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET.
Erinn B Rankin, Katherine C Fuh, Laura Castellini, Kartik Viswanathan, Elizabeth C Finger, Anh N Diep, Edward L LaGory, Mihalis S Kariolis, Andy Chan, David Lindgren,[...]. Proc Natl Acad Sci U S A 2014
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16
Axl and growth arrest-specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiforme.
Markus Hutterer, Pjotr Knyazev, Ariane Abate, Markus Reschke, Hans Maier, Nadia Stefanova, Tatjana Knyazeva, Verena Barbieri, Markus Reindl, Armin Muigg,[...]. Clin Cancer Res 2008
Markus Hutterer, Pjotr Knyazev, Ariane Abate, Markus Reschke, Hans Maier, Nadia Stefanova, Tatjana Knyazeva, Verena Barbieri, Markus Reindl, Armin Muigg,[...]. Clin Cancer Res 2008
15
Expression of axl in lung adenocarcinoma and correlation with tumor progression.
Yi-Shing Shieh, Chiung-Ya Lai, Yu-Rung Kao, Shine-Gwo Shiah, Yi-Wen Chu, Herng-Sheng Lee, Cheng-Wen Wu. Neoplasia 2005
Yi-Shing Shieh, Chiung-Ya Lai, Yu-Rung Kao, Shine-Gwo Shiah, Yi-Wen Chu, Herng-Sheng Lee, Cheng-Wen Wu. Neoplasia 2005
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Cloning and mRNA expression analysis of a novel human protooncogene, c-mer.
D K Graham, T L Dawson, D L Mullaney, H R Snodgrass, H S Earp. Cell Growth Differ 1994
D K Graham, T L Dawson, D L Mullaney, H R Snodgrass, H S Earp. Cell Growth Differ 1994
15
Genes specifically expressed at growth arrest of mammalian cells.
C Schneider, R M King, L Philipson. Cell 1988
C Schneider, R M King, L Philipson. Cell 1988
15
A novel receptor tyrosine kinase, Mer, inhibits TNF-alpha production and lipopolysaccharide-induced endotoxic shock.
T D Camenisch, B H Koller, H S Earp, G K Matsushima. J Immunol 1999
T D Camenisch, B H Koller, H S Earp, G K Matsushima. J Immunol 1999
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AXL induces epithelial-to-mesenchymal transition and regulates the function of breast cancer stem cells.
M K Asiedu, F D Beauchamp-Perez, J N Ingle, M D Behrens, D C Radisky, K L Knutson. Oncogene 2014
M K Asiedu, F D Beauchamp-Perez, J N Ingle, M D Behrens, D C Radisky, K L Knutson. Oncogene 2014
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AXL is an essential factor and therapeutic target for metastatic ovarian cancer.
Erinn B Rankin, Katherine C Fuh, Tiffany E Taylor, Adam J Krieg, Margaret Musser, Jenny Yuan, Kevin Wei, Calvin J Kuo, Teri A Longacre, Amato J Giaccia. Cancer Res 2010
Erinn B Rankin, Katherine C Fuh, Tiffany E Taylor, Adam J Krieg, Margaret Musser, Jenny Yuan, Kevin Wei, Calvin J Kuo, Teri A Longacre, Amato J Giaccia. Cancer Res 2010
14
A novel tyrosine kinase switch is a mechanism of imatinib resistance in gastrointestinal stromal tumors.
D Mahadevan, L Cooke, C Riley, R Swart, B Simons, K Della Croce, L Wisner, M Iorio, K Shakalya, H Garewal,[...]. Oncogene 2007
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MET and AXL inhibitor NPS-1034 exerts efficacy against lung cancer cells resistant to EGFR kinase inhibitors because of MET or AXL activation.
Jin Kyung Rho, Yun Jung Choi, Seon Ye Kim, Tae Won Kim, Eun Kyung Choi, Seon-Joo Yoon, Bu Man Park, Eunhye Park, Jong Hwan Bae, Chang-Min Choi,[...]. Cancer Res 2014
Jin Kyung Rho, Yun Jung Choi, Seon Ye Kim, Tae Won Kim, Eun Kyung Choi, Seon-Joo Yoon, Bu Man Park, Eunhye Park, Jong Hwan Bae, Chang-Min Choi,[...]. Cancer Res 2014
14
An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis.
Mihalis S Kariolis, Yu Rebecca Miao, Douglas S Jones, Shiven Kapur, Irimpan I Mathews, Amato J Giaccia, Jennifer R Cochran. Nat Chem Biol 2014
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Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis.
A Angelillo-Scherrer, P de Frutos, C Aparicio, E Melis, P Savi, F Lupu, J Arnout, M Dewerchin, M Hoylaerts, J Herbert,[...]. Nat Med 2001
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Gas6 and protein S. Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily.
Sassan Hafizi, Björn Dahlbäck. FEBS J 2006
Sassan Hafizi, Björn Dahlbäck. FEBS J 2006
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Targeting Axl and Mer kinases in cancer.
Anupam Verma, Steven L Warner, Hariprasad Vankayalapati, David J Bearss, Sunil Sharma. Mol Cancer Ther 2011
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Tyro-3 family receptors are essential regulators of mammalian spermatogenesis.
Q Lu, M Gore, Q Zhang, T Camenisch, S Boast, F Casagranda, C Lai, M K Skinner, R Klein, G K Matsushima,[...]. Nature 1999
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Axl mediates acquired resistance of head and neck cancer cells to the epidermal growth factor receptor inhibitor erlotinib.
Keith M Giles, Felicity C Kalinowski, Patrick A Candy, Michael R Epis, Priscilla M Zhang, Andrew D Redfern, Lisa M Stuart, Gregory J Goodall, Peter J Leedman. Mol Cancer Ther 2013
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AXL inhibition sensitizes mesenchymal cancer cells to antimitotic drugs.
Catherine Wilson, Xiaofen Ye, Thinh Pham, Eva Lin, Sara Chan, Erin McNamara, Richard M Neve, Lisa Belmont, Hartmut Koeppen, Robert L Yauch,[...]. Cancer Res 2014
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AXL mediates resistance to cetuximab therapy.
Toni M Brand, Mari Iida, Andrew P Stein, Kelsey L Corrigan, Cara M Braverman, Neha Luthar, Mahmoud Toulany, Parkash S Gill, Ravi Salgia, Randall J Kimple,[...]. Cancer Res 2014
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13
13
TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis.
Jonathan H M van der Meer, Tom van der Poll, Cornelis van 't Veer. Blood 2014
Jonathan H M van der Meer, Tom van der Poll, Cornelis van 't Veer. Blood 2014
13
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.