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Single missense mutation in the tyrosine kinase catalytic domain of the RET protooncogene is associated with multiple endocrine neoplasia type 2B.
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A comprehensive overview of the role of the RET proto-oncogene in thyroid carcinoma.
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RET, ROS1 and ALK fusions in lung cancer.
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Selective RET kinase inhibition for patients with RET-altered cancers.
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Multiple endocrine neoplasia type 2 RET protooncogene database: repository of MEN2-associated RET sequence variation and reference for genotype/phenotype correlations.
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Premonitory symptoms preceding metastatic medullary thyroid cancer in MEN 2B: An exploratory analysis.
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Prognosis of medullary thyroid carcinoma: demographic, clinical, and pathologic predictors of survival in 1252 cases.
Sanziana Roman, Rong Lin, Julie Ann Sosa. Cancer 2006
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Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC.
L M Mulligan, C Eng, C S Healey, D Clayton, J B Kwok, E Gardner, M A Ponder, A Frilling, C E Jackson, H Lehnert. Nat Genet 1994
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Incidence and prevalence of multiple endocrine neoplasia 2B in Denmark: a nationwide study.
Jes Sloth Mathiesen, Jens Peter Kroustrup, Peter Vestergaard, Mette Madsen, Kirstine Stochholm, Per Løgstrup Poulsen, Åse Krogh Rasmussen, Ulla Feldt-Rasmussen, Sten Schytte, Henrik Baymler Pedersen,[...]. Endocr Relat Cancer 2017
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Prognostic significance of somatic RET oncogene mutations in sporadic medullary thyroid cancer: a 10-year follow-up study.
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11
RET Solvent Front Mutations Mediate Acquired Resistance to Selective RET Inhibition in RET-Driven Malignancies.
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Efficacy of Selpercatinib in RET-Altered Thyroid Cancers.
Lori J Wirth, Eric Sherman, Bruce Robinson, Benjamin Solomon, Hyunseok Kang, Jochen Lorch, Francis Worden, Marcia Brose, Jyoti Patel, Sophie Leboulleux,[...]. N Engl J Med 2020
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Molecular mechanisms of RET receptor-mediated oncogenesis in multiple endocrine neoplasia 2B.
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Structure and chemical inhibition of the RET tyrosine kinase domain.
Phillip P Knowles, Judith Murray-Rust, Svend Kjaer, Rizaldy P Scott, Sarah Hanrahan, Massimo Santoro, Carlos F Ibáñez, Neil Q McDonald. J Biol Chem 2006
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Targeting RET-driven cancers: lessons from evolving preclinical and clinical landscapes.
Alexander Drilon, Zishuo I Hu, Gillianne G Y Lai, Daniel S W Tan. Nat Rev Clin Oncol 2018
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The GDNF family: signalling, biological functions and therapeutic value.
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Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans.
Iván Plaza-Menacho, Karin Barnouin, Kerry Goodman, Rubén J Martínez-Torres, Annabel Borg, Judith Murray-Rust, Stephane Mouilleron, Phillip Knowles, Neil Q McDonald. Mol Cell 2014
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Correlative analyses of RET and RAS mutations in a phase 3 trial of cabozantinib in patients with progressive, metastatic medullary thyroid cancer.
Steven I Sherman, Douglas O Clary, Rossella Elisei, Martin J Schlumberger, Ezra E W Cohen, Patrick Schöffski, Lori J Wirth, Milan Mangeshkar, Dana T Aftab, Marcia S Brose. Cancer 2016
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High prevalence of RAS mutations in RET-negative sporadic medullary thyroid carcinomas.
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Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer.
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9
Vandetanib in patients with previously treated RET-rearranged advanced non-small-cell lung cancer (LURET): an open-label, multicentre phase 2 trial.
Kiyotaka Yoh, Takashi Seto, Miyako Satouchi, Makoto Nishio, Noboru Yamamoto, Haruyasu Murakami, Naoyuki Nogami, Shingo Matsumoto, Takashi Kohno, Koji Tsuta,[...]. Lancet Respir Med 2017
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Natural history, treatment, and long-term follow up of patients with multiple endocrine neoplasia type 2B: an international, multicentre, retrospective study.
Frederic Castinetti, Steven G Waguespack, Andreas Machens, Shinya Uchino, Kornelia Hasse-Lazar, Gabriella Sanso, Tobias Else, Sarka Dvorakova, Xiao Ping Qi, Rossella Elisei,[...]. Lancet Diabetes Endocrinol 2019
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Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1).
Rajesh V Thakker, Paul J Newey, Gerard V Walls, John Bilezikian, Henning Dralle, Peter R Ebeling, Shlomo Melmed, Akihiro Sakurai, Francesco Tonelli, Maria Luisa Brandi. J Clin Endocrinol Metab 2012
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Multiple endocrine neoplasia type 2 and familial medullary thyroid carcinoma: an update.
Samuel A Wells, Furio Pacini, Bruce G Robinson, Massimo Santoro. J Clin Endocrinol Metab 2013
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Early malignant progression of hereditary medullary thyroid cancer.
Andreas Machens, Patricia Niccoli-Sire, Josef Hoegel, Karin Frank-Raue, Theo J van Vroonhoven, Hans-Dietrich Roeher, Robert A Wahl, Peter Lamesch, Friedhelm Raue, Bernard Conte-Devolx,[...]. N Engl J Med 2003
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Epidemiology, clinical features, and genetics of multiple endocrine neoplasia type 2B in a complete population.
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Somatic RAS mutations occur in a large proportion of sporadic RET-negative medullary thyroid carcinomas and extend to a previously unidentified exon.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.