A citation-based method for searching scientific literature

Y Echelard, D J Epstein, B St-Jacques, L Shen, J Mohler, J A McMahon, A P McMahon. Cell 1993
Times Cited: 1757







List of co-cited articles
1106 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Sonic hedgehog mediates the polarizing activity of the ZPA.
R D Riddle, R L Johnson, E Laufer, C Tabin. Cell 1993
29

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.
C Chiang, Y Litingtung, E Lee, K E Young, J L Corden, H Westphal, P A Beachy. Nature 1996
26

Mutations affecting segment number and polarity in Drosophila.
C Nüsslein-Volhard, E Wieschaus. Nature 1980
23

Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord.
H Roelink, A Augsburger, J Heemskerk, V Korzh, S Norlin, A Ruiz i Altaba, Y Tanabe, M Placzek, T Edlund, T M Jessell. Cell 1994
747
23


The mechanisms of Hedgehog signalling and its roles in development and disease.
James Briscoe, Pascal P Thérond. Nat Rev Mol Cell Biol 2013
16

Patched1 regulates hedgehog signaling at the primary cilium.
Rajat Rohatgi, Ljiljana Milenkovic, Matthew P Scott. Science 2007
989
15


Biochemical evidence that patched is the Hedgehog receptor.
V Marigo, R A Davey, Y Zuo, J M Cunningham, C J Tabin. Nature 1996
672
13


Vertebrate Smoothened functions at the primary cilium.
Kevin C Corbit, Pia Aanstad, Veena Singla, Andrew R Norman, Didier Y R Stainier, Jeremy F Reiter. Nature 2005
12

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog.
D M Stone, M Hynes, M Armanini, T A Swanson, Q Gu, R L Johnson, M P Scott, D Pennica, A Goddard, H Phillips,[...]. Nature 1996
904
12

Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities.
Brian D Harfe, Paul J Scherz, Sahar Nissim, Hua Tian, Andrew P McMahon, Clifford J Tabin. Cell 2004
718
11

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.
J Taipale, J K Chen, M K Cooper, B Wang, R K Mann, L Milenkovic, M P Scott, P A Beachy. Nature 2000
11


Hedgehog signalling in the mouse requires intraflagellar transport proteins.
Danwei Huangfu, Aimin Liu, Andrew S Rakeman, Noel S Murcia, Lee Niswander, Kathryn V Anderson. Nature 2003
996
11

Altered neural cell fates and medulloblastoma in mouse patched mutants.
L V Goodrich, L Milenković, K M Higgins, M P Scott. Science 1997
11

Structural basis for the recognition of Sonic Hedgehog by human Patched1.
Xin Gong, Hongwu Qian, Pingping Cao, Xin Zhao, Qiang Zhou, Jianlin Lei, Nieng Yan. Science 2018
122
10

Identification of a palmitic acid-modified form of human Sonic hedgehog.
R B Pepinsky, C Zeng, D Wen, P Rayhorn, D P Baker, K P Williams, S A Bixler, C M Ambrose, E A Garber, K Miatkowski,[...]. J Biol Chem 1998
538
10

Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism.
Eric Dessaud, Lin Lin Yang, Katy Hill, Barny Cox, Fausto Ulloa, Ana Ribeiro, Anita Mynett, Bennett G Novitch, James Briscoe. Nature 2007
376
10


Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand.
Hanna Tukachinsky, Ryan P Kuzmickas, Cindy Y Jao, Jing Liu, Adrian Salic. Cell Rep 2012
132
9

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.
James K Chen, Jussi Taipale, Michael K Cooper, Philip A Beachy. Genes Dev 2002
9

Products, genetic linkage and limb patterning activity of a murine hedgehog gene.
D T Chang, A López, D P von Kessler, C Chiang, B K Simandl, R Zhao, M F Seldin, J F Fallon, P A Beachy. Development 1994
248
9

Small molecule modulation of Smoothened activity.
James K Chen, Jussi Taipale, Keith E Young, Tapan Maiti, Philip A Beachy. Proc Natl Acad Sci U S A 2002
763
9

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.
Giovanni Luchetti, Ria Sircar, Jennifer H Kong, Sigrid Nachtergaele, Andreas Sagner, Eamon Fx Byrne, Douglas F Covey, Christian Siebold, Rajat Rohatgi. Elife 2016
141
9

Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling.
Pengxiang Huang, Daniel Nedelcu, Miyako Watanabe, Cindy Jao, Youngchang Kim, Jing Liu, Adrian Salic. Cell 2016
209
9


Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched.
Yunxiao Zhang, David P Bulkley, Yao Xin, Kelsey J Roberts, Daniel E Asarnow, Ashutosh Sharma, Benjamin R Myers, Wonhwa Cho, Yifan Cheng, Philip A Beachy. Cell 2018
118
8

Mouse Dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling.
Tamara Caspary, María Jesús García-García, Danwei Huangfu, Jonathan T Eggenschwiler, Michael R Wyler, Andrew S Rakeman, Heather L Alcorn, Kathryn V Anderson. Curr Biol 2002
127
8

Structures of human Patched and its complex with native palmitoylated sonic hedgehog.
Xiaofeng Qi, Philip Schmiege, Elias Coutavas, Jiawei Wang, Xiaochun Li. Nature 2018
112
8

Structural basis of Smoothened regulation by its extracellular domains.
Eamon F X Byrne, Ria Sircar, Paul S Miller, George Hedger, Giovanni Luchetti, Sigrid Nachtergaele, Mark D Tully, Laurel Mydock-McGrane, Douglas F Covey, Robert P Rambo,[...]. Nature 2016
214
8

Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling.
Daniel Nedelcu, Jing Liu, Yangqing Xu, Cindy Jao, Adrian Salic. Nat Chem Biol 2013
140
8

Primary Cilia and Mammalian Hedgehog Signaling.
Fiona Bangs, Kathryn V Anderson. Cold Spring Harb Perspect Biol 2017
279
8

The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice.
Toyoaki Tenzen, Benjamin L Allen, Francesca Cole, Jong-Sun Kang, Robert S Krauss, Andrew P McMahon. Dev Cell 2006
273
8

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2.
Michael I Love, Wolfgang Huber, Simon Anders. Genome Biol 2014
7

Genes and molecular pathways underpinning ciliopathies.
Jeremy F Reiter, Michel R Leroux. Nat Rev Mol Cell Biol 2017
574
7


Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched.
Yong Ma, Alfrun Erkner, Ruoyu Gong, Shenqin Yao, Jussi Taipale, Konrad Basler, Philip A Beachy. Cell 2002
223
7

Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form.
Adrian Creanga, Thomas D Glenn, Randall K Mann, Adam M Saunders, William S Talbot, Philip A Beachy. Genes Dev 2012
93
7

Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex.
Xiaofeng Qi, Philip Schmiege, Elias Coutavas, Xiaochun Li. Science 2018
77
9

Developmental roles and clinical significance of hedgehog signaling.
Andrew P McMahon, Philip W Ingham, Clifford J Tabin. Curr Top Dev Biol 2003
677
7

Gli proteins in development and disease.
Chi-Chung Hui, Stephane Angers. Annu Rev Cell Dev Biol 2011
455
7

Sertoli cell signaling by Desert hedgehog regulates the male germline.
M J Bitgood, L Shen, A P McMahon. Curr Biol 1996
472
7

Patched acts catalytically to suppress the activity of Smoothened.
J Taipale, M K Cooper, T Maiti, P A Beachy. Nature 2002
588
7


Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function.
Benjamin L Allen, Jane Y Song, Luisa Izzi, Irene W Althaus, Jong-Sun Kang, Frédéric Charron, Robert S Krauss, Andrew P McMahon. Dev Cell 2011
197
7


Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo.
E Martí, R Takada, D A Bumcrot, H Sasaki, A P McMahon. Development 1995
286
7

Fiji: an open-source platform for biological-image analysis.
Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid,[...]. Nat Methods 2012
7


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.