A citation-based method for searching scientific literature

R L Johnson, A L Rothman, J Xie, L V Goodrich, J W Bare, J M Bonifas, A G Quinn, R M Myers, D R Cox, E H Epstein, M P Scott. Science 1996
Times Cited: 1425







List of co-cited articles
1061 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome.
H Hahn, C Wicking, P G Zaphiropoulous, M R Gailani, S Shanley, A Chidambaram, I Vorechovsky, E Holmberg, A B Unden, S Gillies,[...]. Cell 1996
49

Activating Smoothened mutations in sporadic basal-cell carcinoma.
J Xie, M Murone, S M Luoh, A Ryan, Q Gu, C Zhang, J M Bonifas, C W Lam, M Hynes, A Goddard,[...]. Nature 1998
979
32

Efficacy and safety of vismodegib in advanced basal-cell carcinoma.
Aleksandar Sekulic, Michael R Migden, Anthony E Oro, Luc Dirix, Karl D Lewis, John D Hainsworth, James A Solomon, Simon Yoo, Sarah T Arron, Philip A Friedlander,[...]. N Engl J Med 2012
806
23


Basal cell carcinomas: attack of the hedgehog.
Ervin H Epstein. Nat Rev Cancer 2008
504
16

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma.
Daniel D Von Hoff, Patricia M LoRusso, Charles M Rudin, Josina C Reddy, Robert L Yauch, Raoul Tibes, Glen J Weiss, Mitesh J Borad, Christine L Hann, Julie R Brahmer,[...]. N Engl J Med 2009
803
15

Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma.
Ximena Bonilla, Laurent Parmentier, Bryan King, Fedor Bezrukov, Gürkan Kaya, Vincent Zoete, Vladimir B Seplyarskiy, Hayley J Sharpe, Thomas McKee, Audrey Letourneau,[...]. Nat Genet 2016
196
15

Smoothened variants explain the majority of drug resistance in basal cell carcinoma.
Scott X Atwood, Kavita Y Sarin, Ramon J Whitson, Jiang R Li, Geurim Kim, Melika Rezaee, Mina S Ally, Jinah Kim, Catherine Yao, Anne Lynn S Chang,[...]. Cancer Cell 2015
232
15

Germline mutations in SUFU cause Gorlin syndrome-associated childhood medulloblastoma and redefine the risk associated with PTCH1 mutations.
Miriam J Smith, Christian Beetz, Simon G Williams, Sanjeev S Bhaskar, James O'Sullivan, Beverley Anderson, Sarah B Daly, Jill E Urquhart, Zaynab Bholah, Deemesh Oudit,[...]. J Clin Oncol 2014
138
14


Patched1 regulates hedgehog signaling at the primary cilium.
Rajat Rohatgi, Ljiljana Milenkovic, Matthew P Scott. Science 2007
933
14

Mutations in SUFU predispose to medulloblastoma.
Michael D Taylor, Ling Liu, Corey Raffel, Chi-chung Hui, Todd G Mainprize, Xiaoyun Zhang, Ron Agatep, Sharon Chiappa, Luzhang Gao, Anja Lowrance,[...]. Nat Genet 2002
558
14

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.
Robert L Yauch, Gerrit J P Dijkgraaf, Bruno Alicke, Thomas Januario, Christina P Ahn, Thomas Holcomb, Kanan Pujara, Jeremy Stinson, Christopher A Callahan, Tracy Tang,[...]. Science 2009
611
14

Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma.
Hayley J Sharpe, Gregoire Pau, Gerrit J Dijkgraaf, Nicole Basset-Seguin, Zora Modrusan, Thomas Januario, Vickie Tsui, Alison B Durham, Andrzej A Dlugosz, Peter M Haverty,[...]. Cancer Cell 2015
217
14

The mechanisms of Hedgehog signalling and its roles in development and disease.
James Briscoe, Pascal P Thérond. Nat Rev Mol Cell Biol 2013
928
12

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.
J Taipale, J K Chen, M K Cooper, B Wang, R K Mann, L Milenkovic, M P Scott, P A Beachy. Nature 2000
12

Mutations affecting segment number and polarity in Drosophila.
C Nüsslein-Volhard, E Wieschaus. Nature 1980
12

The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas.
M R Gailani, M Ståhle-Bäckdahl, D J Leffell, M Glynn, P G Zaphiropoulos, C Pressman, A B Undén, M Dean, D E Brash, A E Bale,[...]. Nat Genet 1996
577
12

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.
Marcel Kool, David T W Jones, Natalie Jäger, Paul A Northcott, Trevor J Pugh, Volker Hovestadt, Rosario M Piro, L Adriana Esparza, Shirley L Markant, Marc Remke,[...]. Cancer Cell 2014
412
12

Hedgehog: functions and mechanisms.
Markku Varjosalo, Jussi Taipale. Genes Dev 2008
809
12

Altered neural cell fates and medulloblastoma in mouse patched mutants.
L V Goodrich, L Milenković, K M Higgins, M P Scott. Science 1997
12

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.
James K Chen, Jussi Taipale, Michael K Cooper, Philip A Beachy. Genes Dev 2002
11

Mechanisms and functions of Hedgehog signalling across the metazoa.
Philip W Ingham, Yoshiro Nakano, Claudia Seger. Nat Rev Genet 2011
376
11

Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome.
Jean Y Tang, Julian M Mackay-Wiggan, Michelle Aszterbaum, Robert L Yauch, Joselyn Lindgren, Kris Chang, Carol Coppola, Anita M Chanana, Jackleen Marji, David R Bickers,[...]. N Engl J Med 2012
379
11

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours.
David M Berman, Sunil S Karhadkar, Anirban Maitra, Rocio Montes De Oca, Meg R Gerstenblith, Kimberly Briggs, Antony R Parker, Yutaka Shimada, James R Eshleman, D Neil Watkins,[...]. Nature 2003
11

Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched.
Yunxiao Zhang, David P Bulkley, Yao Xin, Kelsey J Roberts, Daniel E Asarnow, Ashutosh Sharma, Benjamin R Myers, Wonhwa Cho, Yifan Cheng, Philip A Beachy. Cell 2018
91
12

Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists.
Matthias Lauth, Asa Bergström, Takashi Shimokawa, Rune Toftgård. Proc Natl Acad Sci U S A 2007
550
10

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449.
Charles M Rudin, Christine L Hann, John Laterra, Robert L Yauch, Christopher A Callahan, Ling Fu, Thomas Holcomb, Jeremy Stinson, Stephen E Gould, Barbara Coleman,[...]. N Engl J Med 2009
744
10

Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.
Silvia Buonamici, Juliet Williams, Michael Morrissey, Anlai Wang, Ribo Guo, Anthony Vattay, Kathy Hsiao, Jing Yuan, John Green, Beatriz Ospina,[...]. Sci Transl Med 2010
340
10

The primary cilium: a signalling centre during vertebrate development.
Sarah C Goetz, Kathryn V Anderson. Nat Rev Genet 2010
10

Structural basis for the recognition of Sonic Hedgehog by human Patched1.
Xin Gong, Hongwu Qian, Pingping Cao, Xin Zhao, Qiang Zhou, Jianlin Lei, Nieng Yan. Science 2018
96
10

Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas.
J Reifenberger, M Wolter, C B Knobbe, B Köhler, A Schönicke, C Scharwächter, K Kumar, B Blaschke, T Ruzicka, G Reifenberger. Br J Dermatol 2005
269
10

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog.
D M Stone, M Hynes, M Armanini, T A Swanson, Q Gu, R L Johnson, M P Scott, D Pennica, A Goddard, H Phillips,[...]. Nature 1996
891
9

Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway.
Elspeth M Beauchamp, Lymor Ringer, Gülay Bulut, Kamal P Sajwan, Michael D Hall, Yi-Chien Lee, Daniel Peaceman, Metin Ozdemirli, Olga Rodriguez, Tobey J Macdonald,[...]. J Clin Invest 2011
220
9

Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling.
Pengxiang Huang, Daniel Nedelcu, Miyako Watanabe, Cindy Jao, Youngchang Kim, Jing Liu, Adrian Salic. Cell 2016
178
9

Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer.
Makoto Kubo, Masafumi Nakamura, Akira Tasaki, Naoki Yamanaka, Hiroshi Nakashima, Masatoshi Nomura, Syoji Kuroki, Mitsuo Katano. Cancer Res 2004
358
9

Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors.
Tadas K Rimkus, Richard L Carpenter, Shadi Qasem, Michael Chan, Hui-Wen Lo. Cancers (Basel) 2016
316
9

Hedgehog signalling in cancer formation and maintenance.
Marina Pasca di Magliano, Matthias Hebrok. Nat Rev Cancer 2003
629
9


Treatment with two different doses of sonidegib in patients with locally advanced or metastatic basal cell carcinoma (BOLT): a multicentre, randomised, double-blind phase 2 trial.
Michael R Migden, Alexander Guminski, Ralf Gutzmer, Luc Dirix, Karl D Lewis, Patrick Combemale, Robert M Herd, Ragini Kudchadkar, Uwe Trefzer, Sven Gogov,[...]. Lancet Oncol 2015
196
8

Open-label, exploratory phase II trial of oral itraconazole for the treatment of basal cell carcinoma.
Daniel J Kim, James Kim, Katrina Spaunhurst, Javier Montoya, Rita Khodosh, Kalyani Chandra, Teresa Fu, Anita Gilliam, Monserrat Molgo, Philip A Beachy,[...]. J Clin Oncol 2014
152
8

Long-term safety and efficacy of vismodegib in patients with advanced basal cell carcinoma: final update of the pivotal ERIVANCE BCC study.
Aleksandar Sekulic, Michael R Migden, Nicole Basset-Seguin, Claus Garbe, Anja Gesierich, Christopher D Lao, Chris Miller, Laurent Mortier, Dedee F Murrell, Omid Hamid,[...]. BMC Cancer 2017
139
8

Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector.
Jynho Kim, John J Lee, James Kim, Dale Gardner, Philip A Beachy. Proc Natl Acad Sci U S A 2010
207
8

Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors.
Patricia M LoRusso, Charles M Rudin, Josina C Reddy, Raoul Tibes, Glen J Weiss, Mitesh J Borad, Christine L Hann, Julie R Brahmer, Ilsung Chang, Walter C Darbonne,[...]. Clin Cancer Res 2011
391
8

Structure of the human smoothened receptor bound to an antitumour agent.
Chong Wang, Huixian Wu, Vsevolod Katritch, Gye Won Han, Xi-Ping Huang, Wei Liu, Fai Yiu Siu, Bryan L Roth, Vadim Cherezov, Raymond C Stevens. Nature 2013
327
8

Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists.
James Kim, Blake T Aftab, Jean Y Tang, Daniel Kim, Alex H Lee, Melika Rezaee, Jynho Kim, Baozhi Chen, Emily M King, Alexandra Borodovsky,[...]. Cancer Cell 2013
233
8

Identification of a SUFU germline mutation in a family with Gorlin syndrome.
L Pastorino, P Ghiorzo, S Nasti, L Battistuzzi, R Cusano, C Marzocchi, M L Garrè, M Clementi, G Bianchi Scarrà. Am J Med Genet A 2009
109
8

Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway.
Jessica Svärd, Karin Heby-Henricson, Madelen Persson-Lek, Björn Rozell, Matthias Lauth, Asa Bergström, Johan Ericson, Rune Toftgård, Stephan Teglund. Dev Cell 2006
345
8

Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032.
Giles W Robinson, Brent A Orr, Gang Wu, Sridharan Gururangan, Tong Lin, Ibrahim Qaddoumi, Roger J Packer, Stewart Goldman, Michael D Prados, Annick Desjardins,[...]. J Clin Oncol 2015
220
8

Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth.
James Kim, Jean Y Tang, Ruoyu Gong, Jynho Kim, John J Lee, Karl V Clemons, Curtis R Chong, Kris S Chang, Mark Fereshteh, Dale Gardner,[...]. Cancer Cell 2010
331
8


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.