T E Willnow, J Hilpert, S A Armstrong, A Rohlmann, R E Hammer, D K Burns, J Herz. Proc Natl Acad Sci U S A 1996
Times Cited: 399
Times Cited: 399
Times Cited
Times Co-cited
Similarity
Mutations in LRP2, which encodes the multiligand receptor megalin, cause Donnai-Barrow and facio-oculo-acoustico-renal syndromes.
Sibel Kantarci, Lihadh Al-Gazali, R Sean Hill, Dian Donnai, Graeme C M Black, Eric Bieth, Nicolas Chassaing, Didier Lacombe, Koen Devriendt, Ahmad Teebi,[...]. Nat Genet 2007
Sibel Kantarci, Lihadh Al-Gazali, R Sean Hill, Dian Donnai, Graeme C M Black, Eric Bieth, Nicolas Chassaing, Didier Lacombe, Koen Devriendt, Ahmad Teebi,[...]. Nat Genet 2007
38
LRP2/megalin is required for patterning of the ventral telencephalon.
Robert Spoelgen, Annette Hammes, Uwe Anzenberger, Dietmar Zechner, Olav M Andersen, Boris Jerchow, Thomas E Willnow. Development 2005
Robert Spoelgen, Annette Hammes, Uwe Anzenberger, Dietmar Zechner, Olav M Andersen, Boris Jerchow, Thomas E Willnow. Development 2005
29
LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals.
Annabel Christ, Anna Christa, Esther Kur, Oleg Lioubinski, Sebastian Bachmann, Thomas E Willnow, Annette Hammes. Dev Cell 2012
Annabel Christ, Anna Christa, Esther Kur, Oleg Lioubinski, Sebastian Bachmann, Thomas E Willnow, Annette Hammes. Dev Cell 2012
29
Megalin and cubilin: multifunctional endocytic receptors.
Erik Ilsø Christensen, Henrik Birn. Nat Rev Mol Cell Biol 2002
Erik Ilsø Christensen, Henrik Birn. Nat Rev Mol Cell Biol 2002
18
An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3.
A Nykjaer, D Dragun, D Walther, H Vorum, C Jacobsen, J Herz, F Melsen, E I Christensen, T E Willnow. Cell 1999
A Nykjaer, D Dragun, D Walther, H Vorum, C Jacobsen, J Herz, F Melsen, E I Christensen, T E Willnow. Cell 1999
18
Megalin knockout mice as an animal model of low molecular weight proteinuria.
J R Leheste, B Rolinski, H Vorum, J Hilpert, A Nykjaer, C Jacobsen, P Aucouturier, J O Moskaug, A Otto, E I Christensen,[...]. Am J Pathol 1999
J R Leheste, B Rolinski, H Vorum, J Hilpert, A Nykjaer, C Jacobsen, P Aucouturier, J O Moskaug, A Otto, E I Christensen,[...]. Am J Pathol 1999
15
Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family.
A Saito, S Pietromonaco, A K Loo, M G Farquhar. Proc Natl Acad Sci U S A 1994
A Saito, S Pietromonaco, A K Loo, M G Farquhar. Proc Natl Acad Sci U S A 1994
14
New insights into the roles of megalin/LRP2 and the regulation of its functional expression.
María-Paz Marzolo, Pamela Farfán. Biol Res 2011
María-Paz Marzolo, Pamela Farfán. Biol Res 2011
13
Role of endocytosis in cellular uptake of sex steroids.
Annette Hammes, Thomas K Andreassen, Robert Spoelgen, Jens Raila, Norbert Hubner, Herbert Schulz, Jochen Metzger, Florian J Schweigert, Peter B Luppa, Anders Nykjaer,[...]. Cell 2005
Annette Hammes, Thomas K Andreassen, Robert Spoelgen, Jens Raila, Norbert Hubner, Herbert Schulz, Jochen Metzger, Florian J Schweigert, Peter B Luppa, Anders Nykjaer,[...]. Cell 2005
12
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.
C Chiang, Y Litingtung, E Lee, K E Young, J L Corden, H Westphal, P A Beachy. Nature 1996
C Chiang, Y Litingtung, E Lee, K E Young, J L Corden, H Westphal, P A Beachy. Nature 1996
11
Megalin functions as an endocytic sonic hedgehog receptor.
Robert A McCarthy, Jeremy L Barth, Mastan R Chintalapudi, Christian Knaak, W Scott Argraves. J Biol Chem 2002
Robert A McCarthy, Jeremy L Barth, Mastan R Chintalapudi, Christian Knaak, W Scott Argraves. J Biol Chem 2002
10
Overlapping expression patterns of the multiligand endocytic receptors cubilin and megalin in the CNS, sensory organs and developing epithelia of the rodent embryo.
Emeline Assémat, François Châtelet, Jacqueline Chandellier, Frédéric Commo, Olivier Cases, Pierre Verroust, Renata Kozyraki. Gene Expr Patterns 2005
Emeline Assémat, François Châtelet, Jacqueline Chandellier, Frédéric Commo, Olivier Cases, Pierre Verroust, Renata Kozyraki. Gene Expr Patterns 2005
20
The role of megalin (LRP-2/Gp330) during development.
Carolyn E Fisher, Sarah E M Howie. Dev Biol 2006
Carolyn E Fisher, Sarah E M Howie. Dev Biol 2006
18
A review of Donnai-Barrow and facio-oculo-acoustico-renal (DB/FOAR) syndrome: clinical features and differential diagnosis.
Barbara R Pober, Mauro Longoni, Kristin M Noonan. Birth Defects Res A Clin Mol Teratol 2009
Barbara R Pober, Mauro Longoni, Kristin M Noonan. Birth Defects Res A Clin Mol Teratol 2009
20
Megalin and the neurodevelopmental biology of sonic hedgehog and retinol.
Robert A McCarthy, W Scott Argraves. J Cell Sci 2003
Robert A McCarthy, W Scott Argraves. J Cell Sci 2003
21
LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche.
Chandresh R Gajera, Helena Emich, Oleg Lioubinski, Annabel Christ, Ruth Beckervordersandforth-Bonk, Kazuaki Yoshikawa, Sebastian Bachmann, Erik Ilsø Christensen, Magdalena Götz, Gerd Kempermann,[...]. J Cell Sci 2010
Chandresh R Gajera, Helena Emich, Oleg Lioubinski, Annabel Christ, Ruth Beckervordersandforth-Bonk, Kazuaki Yoshikawa, Sebastian Bachmann, Erik Ilsø Christensen, Magdalena Götz, Gerd Kempermann,[...]. J Cell Sci 2010
9
LRP2 mediates folate uptake in the developing neural tube.
Esther Kur, Nora Mecklenburg, Robert M Cabrera, Thomas E Willnow, Annette Hammes. J Cell Sci 2014
Esther Kur, Nora Mecklenburg, Robert M Cabrera, Thomas E Willnow, Annette Hammes. J Cell Sci 2014
31
LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation.
J Herz, D E Clouthier, R E Hammer. Cell 1992
J Herz, D E Clouthier, R E Hammer. Cell 1992
8
Targeted disruption of cubilin reveals essential developmental roles in the structure and function of endoderm and in somite formation.
Brian T Smith, Jason C Mussell, Paul A Fleming, Jeremy L Barth, Demetri D Spyropoulos, Marion A Cooley, Christopher J Drake, W Scott Argraves. BMC Dev Biol 2006
Brian T Smith, Jason C Mussell, Paul A Fleming, Jeremy L Barth, Demetri D Spyropoulos, Marion A Cooley, Christopher J Drake, W Scott Argraves. BMC Dev Biol 2006
15
The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border.
D Kerjaschki, M G Farquhar. Proc Natl Acad Sci U S A 1982
D Kerjaschki, M G Farquhar. Proc Natl Acad Sci U S A 1982
8
Endocytic receptors in the renal proximal tubule.
Erik I Christensen, Henrik Birn, Tina Storm, Kathrin Weyer, Rikke Nielsen. Physiology (Bethesda) 2012
Erik I Christensen, Henrik Birn, Tina Storm, Kathrin Weyer, Rikke Nielsen. Physiology (Bethesda) 2012
8
Cubilin is essential for albumin reabsorption in the renal proximal tubule.
Sabine Amsellem, Jakub Gburek, Ghislaine Hamard, Rikke Nielsen, Thomas E Willnow, Olivier Devuyst, Ebba Nexo, Pierre J Verroust, Erik I Christensen, Renata Kozyraki. J Am Soc Nephrol 2010
Sabine Amsellem, Jakub Gburek, Ghislaine Hamard, Rikke Nielsen, Thomas E Willnow, Olivier Devuyst, Ebba Nexo, Pierre J Verroust, Erik I Christensen, Renata Kozyraki. J Am Soc Nephrol 2010
8
A cytoplasmic PPPSP motif determines megalin's phosphorylation and regulates receptor's recycling and surface expression.
María Isabel Yuseff, Pamela Farfan, Guojun Bu, María-Paz Marzolo. Traffic 2007
María Isabel Yuseff, Pamela Farfan, Guojun Bu, María-Paz Marzolo. Traffic 2007
20
Linking receptor-mediated endocytosis and cell signaling: evidence for regulated intramembrane proteolysis of megalin in proximal tubule.
Zhiying Zou, Brian Chung, Thao Nguyen, Sueann Mentone, Brent Thomson, Daniel Biemesderfer. J Biol Chem 2004
Zhiying Zou, Brian Chung, Thao Nguyen, Sueann Mentone, Brent Thomson, Daniel Biemesderfer. J Biol Chem 2004
7
Renal phenotypic investigations of megalin-deficient patients: novel insights into tubular proteinuria and albumin filtration.
Tina Storm, Lisbeth Tranebjærg, Carina Frykholm, Henrik Birn, Pierre J Verroust, Tryggve Nevéus, Birgitta Sundelin, Jens Michael Hertz, Gerd Holmström, Katharina Ericson,[...]. Nephrol Dial Transplant 2013
Tina Storm, Lisbeth Tranebjærg, Carina Frykholm, Henrik Birn, Pierre J Verroust, Tryggve Nevéus, Birgitta Sundelin, Jens Michael Hertz, Gerd Holmström, Katharina Ericson,[...]. Nephrol Dial Transplant 2013
14
Mouse model of proximal tubule endocytic dysfunction.
Kathrin Weyer, Tina Storm, Jingdong Shan, Seppo Vainio, Renata Kozyraki, Pierre J Verroust, Erik I Christensen, Rikke Nielsen. Nephrol Dial Transplant 2011
Kathrin Weyer, Tina Storm, Jingdong Shan, Seppo Vainio, Renata Kozyraki, Pierre J Verroust, Erik I Christensen, Rikke Nielsen. Nephrol Dial Transplant 2011
12
Low-density lipoprotein receptor-related protein (LRP)-2/megalin is transiently expressed in a subpopulation of neural progenitors in the embryonic mouse spinal cord.
Grzegorz Wicher, Mårten Larsson, Lars Rask, Håkan Aldskogius. J Comp Neurol 2005
Grzegorz Wicher, Mårten Larsson, Lars Rask, Håkan Aldskogius. J Comp Neurol 2005
41
Choroid plexus megalin is involved in neuroprotection by serum insulin-like growth factor I.
Eva Carro, Carlos Spuch, Jose Luis Trejo, Desiré Antequera, Ignacio Torres-Aleman. J Neurosci 2005
Eva Carro, Carlos Spuch, Jose Luis Trejo, Desiré Antequera, Ignacio Torres-Aleman. J Neurosci 2005
7
Mutations in the human Sonic Hedgehog gene cause holoprosencephaly.
E Roessler, E Belloni, K Gaudenz, P Jay, P Berta, S W Scherer, L C Tsui, M Muenke. Nat Genet 1996
E Roessler, E Belloni, K Gaudenz, P Jay, P Berta, S W Scherer, L C Tsui, M Muenke. Nat Genet 1996
7
Tissue distribution of human gp330/megalin, a putative Ca(2+)-sensing protein.
S Lundgren, T Carling, G Hjälm, C Juhlin, J Rastad, U Pihlgren, L Rask, G Akerström, P Hellman. J Histochem Cytochem 1997
S Lundgren, T Carling, G Hjälm, C Juhlin, J Rastad, U Pihlgren, L Rask, G Akerström, P Hellman. J Histochem Cytochem 1997
7
Megalin-deficiency causes high myopia, retinal pigment epithelium-macromelanosomes and abnormal development of the ciliary body in mice.
Tina Storm, Steffen Heegaard, Erik I Christensen, Rikke Nielsen. Cell Tissue Res 2014
Tina Storm, Steffen Heegaard, Erik I Christensen, Rikke Nielsen. Cell Tissue Res 2014
41
Identification of an apical sorting determinant in the cytoplasmic tail of megalin.
Tetsuro Takeda, Hajime Yamazaki, Marilyn G Farquhar. Am J Physiol Cell Physiol 2003
Tetsuro Takeda, Hajime Yamazaki, Marilyn G Farquhar. Am J Physiol Cell Physiol 2003
7
Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect.
Jörg R Leheste, Flemming Melsen, Maren Wellner, Pernille Jansen, Uwe Schlichting, Ingrid Renner-Müller, Troels T Andreassen, Eckehard Wolf, Sebastian Bachmann, Anders Nykjaer,[...]. FASEB J 2003
Jörg R Leheste, Flemming Melsen, Maren Wellner, Pernille Jansen, Uwe Schlichting, Ingrid Renner-Müller, Troels T Andreassen, Eckehard Wolf, Sebastian Bachmann, Anders Nykjaer,[...]. FASEB J 2003
7
Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP/alpha 2MR, and the receptor-associated protein (RAP).
G Zheng, D R Bachinsky, I Stamenkovic, D K Strickland, D Brown, G Andres, R T McCluskey. J Histochem Cytochem 1994
G Zheng, D R Bachinsky, I Stamenkovic, D K Strickland, D Brown, G Andres, R T McCluskey. J Histochem Cytochem 1994
7
Common arterial trunk and ventricular non-compaction in Lrp2 knockout mice indicate a crucial role of LRP2 in cardiac development.
Maria E Baardman, Mathijs V Zwier, Lambertus J Wisse, Adriana C Gittenberger-de Groot, Wilhelmina S Kerstjens-Frederikse, Robert M W Hofstra, Angelika Jurdzinski, Beerend P Hierck, Monique R M Jongbloed, Rolf M F Berger,[...]. Dis Model Mech 2016
Maria E Baardman, Mathijs V Zwier, Lambertus J Wisse, Adriana C Gittenberger-de Groot, Wilhelmina S Kerstjens-Frederikse, Robert M W Hofstra, Angelika Jurdzinski, Beerend P Hierck, Monique R M Jongbloed, Rolf M F Berger,[...]. Dis Model Mech 2016
29
Megalin and cubilin in proximal tubule protein reabsorption: from experimental models to human disease.
Rikke Nielsen, Erik Ilsø Christensen, Henrik Birn. Kidney Int 2016
Rikke Nielsen, Erik Ilsø Christensen, Henrik Birn. Kidney Int 2016
7
Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly.
Wei Zhang, Jong-Sun Kang, Francesca Cole, Min-Jeong Yi, Robert S Krauss. Dev Cell 2006
Wei Zhang, Jong-Sun Kang, Francesca Cole, Min-Jeong Yi, Robert S Krauss. Dev Cell 2006
6
Lipoproteins and their receptors in embryonic development: more than cholesterol clearance.
Thomas E Willnow, Annette Hammes, Suzanne Eaton. Development 2007
Thomas E Willnow, Annette Hammes, Suzanne Eaton. Development 2007
11
Epithelial trafficking of Sonic hedgehog by megalin.
Carlos R Morales, Jibin Zeng, Mohamed El Alfy, Jeremy L Barth, Mastan Rao Chintalapudi, Robert A McCarthy, John P Incardona, W Scott Argraves. J Histochem Cytochem 2006
Carlos R Morales, Jibin Zeng, Mohamed El Alfy, Jeremy L Barth, Mastan Rao Chintalapudi, Robert A McCarthy, John P Incardona, W Scott Argraves. J Histochem Cytochem 2006
21
Patched1 regulates hedgehog signaling at the primary cilium.
Rajat Rohatgi, Ljiljana Milenkovic, Matthew P Scott. Science 2007
Rajat Rohatgi, Ljiljana Milenkovic, Matthew P Scott. Science 2007
6
Megalin is a receptor for albumin in astrocytes and is required for the synthesis of the neurotrophic factor oleic acid.
André Bento-Abreu, Ana Velasco, Erica Polo-Hernández, Pedro Luis Pérez-Reyes, Arantxa Tabernero, José M Medina. J Neurochem 2008
André Bento-Abreu, Ana Velasco, Erica Polo-Hernández, Pedro Luis Pérez-Reyes, Arantxa Tabernero, José M Medina. J Neurochem 2008
13
Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.
M Trommsdorff, M Gotthardt, T Hiesberger, J Shelton, W Stockinger, J Nimpf, R E Hammer, J A Richardson, J Herz. Cell 1999
M Trommsdorff, M Gotthardt, T Hiesberger, J Shelton, W Stockinger, J Nimpf, R E Hammer, J A Richardson, J Herz. Cell 1999
6
Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation.
T Hiesberger, M Trommsdorff, B W Howell, A Goffinet, M C Mumby, J A Cooper, J Herz. Neuron 1999
T Hiesberger, M Trommsdorff, B W Howell, A Goffinet, M C Mumby, J A Cooper, J Herz. Neuron 1999
6
Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.
M Gotthardt, M Trommsdorff, M F Nevitt, J Shelton, J A Richardson, W Stockinger, J Nimpf, J Herz. J Biol Chem 2000
M Gotthardt, M Trommsdorff, M F Nevitt, J Shelton, J A Richardson, W Stockinger, J Nimpf, J Herz. J Biol Chem 2000
6
Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning.
Edwin J Weeber, Uwe Beffert, Chris Jones, Jill M Christian, Eckart Forster, J David Sweatt, Joachim Herz. J Biol Chem 2002
Edwin J Weeber, Uwe Beffert, Chris Jones, Jill M Christian, Eckart Forster, J David Sweatt, Joachim Herz. J Biol Chem 2002
6
6
Human endothelial cells of the placental barrier efficiently deliver cholesterol to the fetal circulation via ABCA1 and ABCG1.
Jasminka Stefulj, Ute Panzenboeck, Tatjana Becker, Birgit Hirschmugl, Cornelia Schweinzer, Ingrid Lang, Gunther Marsche, Anton Sadjak, Uwe Lang, Gernot Desoye,[...]. Circ Res 2009
Jasminka Stefulj, Ute Panzenboeck, Tatjana Becker, Birgit Hirschmugl, Cornelia Schweinzer, Ingrid Lang, Gunther Marsche, Anton Sadjak, Uwe Lang, Gernot Desoye,[...]. Circ Res 2009
6
Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes.
R V Farese, S L Ruland, L M Flynn, R P Stokowski, S G Young. Proc Natl Acad Sci U S A 1995
R V Farese, S L Ruland, L M Flynn, R P Stokowski, S G Young. Proc Natl Acad Sci U S A 1995
6
The visceral yolk sac endoderm provides for absorption of nutrients to the embryo during neurulation.
Irene E Zohn, Anjali A Sarkar. Birth Defects Res A Clin Mol Teratol 2010
Irene E Zohn, Anjali A Sarkar. Birth Defects Res A Clin Mol Teratol 2010
9
Multiligand endocytosis and congenital defects: roles of cubilin, megalin and amnionless.
Renata Kozyraki, Françoise Gofflot. Curr Pharm Des 2007
Renata Kozyraki, Françoise Gofflot. Curr Pharm Des 2007
16
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.