A citation-based method for searching scientific literature

J A Porter, K E Young, P A Beachy. Science 1996
Times Cited: 987







List of co-cited articles
1106 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Identification of a palmitic acid-modified form of human Sonic hedgehog.
R B Pepinsky, C Zeng, D Wen, P Rayhorn, D P Baker, K P Williams, S A Bixler, C M Ambrose, E A Garber, K Miatkowski,[...]. J Biol Chem 1998
518
26

Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling.
Xu Xiao, Jing-Jie Tang, Chao Peng, Yan Wang, Lin Fu, Zhi-Ping Qiu, Yue Xiong, Lian-Fang Yang, Hai-Wei Cui, Xiao-Long He,[...]. Mol Cell 2017
93
25

Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand.
Hanna Tukachinsky, Ryan P Kuzmickas, Cindy Y Jao, Jing Liu, Adrian Salic. Cell Rep 2012
124
20

The mechanisms of Hedgehog signalling and its roles in development and disease.
James Briscoe, Pascal P Thérond. Nat Rev Mol Cell Biol 2013
945
17

A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis.
Michael K Cooper, Christopher A Wassif, Patrycja A Krakowiak, Jussi Taipale, Ruoyu Gong, Richard I Kelley, Forbes D Porter, Philip A Beachy. Nat Genet 2003
275
17

Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling.
Pengxiang Huang, Daniel Nedelcu, Miyako Watanabe, Cindy Jao, Youngchang Kim, Jing Liu, Adrian Salic. Cell 2016
187
17

Structural basis for the recognition of Sonic Hedgehog by human Patched1.
Xin Gong, Hongwu Qian, Pingping Cao, Xin Zhao, Qiang Zhou, Jianlin Lei, Nieng Yan. Science 2018
99
17

Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched.
Yunxiao Zhang, David P Bulkley, Yao Xin, Kelsey J Roberts, Daniel E Asarnow, Ashutosh Sharma, Benjamin R Myers, Wonhwa Cho, Yifan Cheng, Philip A Beachy. Cell 2018
96
17

Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal.
Z Chamoun, R K Mann, D Nellen, D P von Kessler, M Bellotto, P A Beachy, K Basler. Science 2001
300
16


Structures of human Patched and its complex with native palmitoylated sonic hedgehog.
Xiaofeng Qi, Philip Schmiege, Elias Coutavas, Jiawei Wang, Xiaochun Li. Nature 2018
89
16


Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.
Giovanni Luchetti, Ria Sircar, Jennifer H Kong, Sigrid Nachtergaele, Andreas Sagner, Eamon Fx Byrne, Douglas F Covey, Christian Siebold, Rajat Rohatgi. Elife 2016
125
13

Structural basis of Smoothened regulation by its extracellular domains.
Eamon F X Byrne, Ria Sircar, Paul S Miller, George Hedger, Giovanni Luchetti, Sigrid Nachtergaele, Mark D Tully, Laurel Mydock-McGrane, Douglas F Covey, Robert P Rambo,[...]. Nature 2016
190
13

Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form.
Adrian Creanga, Thomas D Glenn, Randall K Mann, Adam M Saunders, William S Talbot, Philip A Beachy. Genes Dev 2012
85
15

Crystal structure of a Hedgehog autoprocessing domain: homology between Hedgehog and self-splicing proteins.
T M Hall, J A Porter, K E Young, E V Koonin, P A Beachy, D J Leahy. Cell 1997
205
12

Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain.
J A Porter, S C Ekker, W J Park, D P von Kessler, K E Young, C H Chen, Y Ma, A S Woods, R J Cotter, E V Koonin,[...]. Cell 1996
397
12

A freely diffusible form of Sonic hedgehog mediates long-range signalling.
X Zeng, J A Goetz, L M Suber, W J Scott, C M Schreiner, D J Robbins. Nature 2001
336
12

Patched acts catalytically to suppress the activity of Smoothened.
J Taipale, M K Cooper, T Maiti, P A Beachy. Nature 2002
571
12

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.
C Chiang, Y Litingtung, E Lee, K E Young, J L Corden, H Westphal, P A Beachy. Nature 1996
11

Mutations affecting segment number and polarity in Drosophila.
C Nüsslein-Volhard, E Wieschaus. Nature 1980
11

Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium.
Benjamin R Myers, Lila Neahring, Yunxiao Zhang, Kelsey J Roberts, Philip A Beachy. Proc Natl Acad Sci U S A 2017
60
18

Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched.
Yong Ma, Alfrun Erkner, Ruoyu Gong, Shenqin Yao, Jussi Taipale, Konrad Basler, Philip A Beachy. Cell 2002
217
11

Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1.
P M Lewis, M P Dunn, J A McMahon, M Logan, J F Martin, B St-Jacques, A P McMahon. Cell 2001
374
11

Novel lipid modifications of secreted protein signals.
Randall K Mann, Philip A Beachy. Annu Rev Biochem 2004
247
10

Lipoprotein particles are required for Hedgehog and Wingless signalling.
Daniela Panáková, Hein Sprong, Eric Marois, Christoph Thiele, Suzanne Eaton. Nature 2005
468
10

Patched1 regulates hedgehog signaling at the primary cilium.
Rajat Rohatgi, Ljiljana Milenkovic, Matthew P Scott. Science 2007
942
9

Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome.
Robert Blassberg, James I Macrae, James Briscoe, John Jacob. Hum Mol Genet 2016
54
16

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling.
Sigrid Nachtergaele, Daniel M Whalen, Laurel K Mydock, Zhonghua Zhao, Tomas Malinauskas, Kathiresan Krishnan, Philip W Ingham, Douglas F Covey, Christian Siebold, Rajat Rohatgi. Elife 2013
104
9

Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex.
Xiaofeng Qi, Philip Schmiege, Elias Coutavas, Xiaochun Li. Science 2018
64
14

Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling.
Daniel Nedelcu, Jing Liu, Yangqing Xu, Cindy Jao, Adrian Salic. Nat Chem Biol 2013
128
9

Autoproteolysis in hedgehog protein biogenesis.
J J Lee, S C Ekker, D P von Kessler, J A Porter, B I Sun, P A Beachy. Science 1994
423
9

The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.
Amalie F Rudolf, Maia Kinnebrew, Christiane Kowatsch, T Bertie Ansell, Kamel El Omari, Benjamin Bishop, Els Pardon, Rebekka A Schwab, Tomas Malinauskas, Mingxing Qian,[...]. Nat Chem Biol 2019
21
42

Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi.
Xiaofeng Qi, Heng Liu, Bonne Thompson, Jeffrey McDonald, Cheng Zhang, Xiaochun Li. Nature 2019
67
13

Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm.
Hongwu Qian, Pingping Cao, Miaohui Hu, Shuai Gao, Nieng Yan, Xin Gong. Nat Commun 2019
35
25

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.
James K Chen, Jussi Taipale, Michael K Cooper, Philip A Beachy. Genes Dev 2002
8

A Single Aspartate Coordinates Two Catalytic Steps in Hedgehog Autoprocessing.
Jian Xie, Timothy Owen, Ke Xia, Brian Callahan, Chunyu Wang. J Am Chem Soc 2016
12
66

Hedgehog: functions and mechanisms.
Markku Varjosalo, Jussi Taipale. Genes Dev 2008
819
8

The product of hedgehog autoproteolytic cleavage active in local and long-range signalling.
J A Porter, D P von Kessler, S C Ekker, K E Young, J J Lee, K Moses, P A Beachy. Nature 1995
413
8

Cytonemes are required for the establishment of a normal Hedgehog morphogen gradient in Drosophila epithelia.
Marcus Bischoff, Ana-Citlali Gradilla, Irene Seijo, Germán Andrés, Carmen Rodríguez-Navas, Laura González-Méndez, Isabel Guerrero. Nat Cell Biol 2013
138
8

Mouse Dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling.
Tamara Caspary, María Jesús García-García, Danwei Huangfu, Jonathan T Eggenschwiler, Michael R Wyler, Andrew S Rakeman, Heather L Alcorn, Kathryn V Anderson. Curr Biol 2002
123
8

Exosomes as Hedgehog carriers in cytoneme-mediated transport and secretion.
Ana-Citlali Gradilla, Esperanza González, Irene Seijo, German Andrés, Marcus Bischoff, Laura González-Mendez, Vanessa Sánchez, Ainhoa Callejo, Carmen Ibáñez, Milagros Guerra,[...]. Nat Commun 2014
108
8


Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response.
Benjamin R Myers, Navdar Sever, Yong Chun Chong, James Kim, Jitendra D Belani, Scott Rychnovsky, J Fernando Bazan, Philip A Beachy. Dev Cell 2013
122
8

Vertebrate Smoothened functions at the primary cilium.
Kevin C Corbit, Pia Aanstad, Veena Singla, Andrew R Norman, Didier Y R Stainier, Jeremy F Reiter. Nature 2005
993
8

Smoothened stimulation by membrane sterols drives Hedgehog pathway activity.
Ishan Deshpande, Jiahao Liang, Danielle Hedeen, Kelsey J Roberts, Yunxiao Zhang, Betty Ha, Naomi R Latorraca, Bryan Faust, Ron O Dror, Philip A Beachy,[...]. Nature 2019
64
12

Mutations in the human Sonic Hedgehog gene cause holoprosencephaly.
E Roessler, E Belloni, K Gaudenz, P Jay, P Berta, S W Scherer, L C Tsui, M Muenke. Nat Genet 1996
841
7

Structure of human Niemann-Pick C1 protein.
Xiaochun Li, Jiawei Wang, Elias Coutavas, Hang Shi, Qi Hao, Günter Blobel. Proc Natl Acad Sci U S A 2016
92
7

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer.
D Neil Watkins, David M Berman, Scott G Burkholder, Baolin Wang, Philip A Beachy, Stephen B Baylin. Nature 2003
828
7

Mutations in the C-terminal domain of Sonic Hedgehog cause holoprosencephaly.
E Roessler, E Belloni, K Gaudenz, F Vargas, S W Scherer, L C Tsui, M Muenke. Hum Mol Genet 1997
131
7


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.