A citation-based method for searching scientific literature

E Roessler, E Belloni, K Gaudenz, P Jay, P Berta, S W Scherer, L C Tsui, M Muenke. Nat Genet 1996
Times Cited: 839







List of co-cited articles
1106 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.
C Chiang, Y Litingtung, E Lee, K E Young, J L Corden, H Westphal, P A Beachy. Nature 1996
43

Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly.
E Belloni, M Muenke, E Roessler, G Traverso, J Siegel-Bartelt, A Frumkin, H F Mitchell, H Donis-Keller, C Helms, A V Hing,[...]. Nat Genet 1996
486
29

Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features.
Erich Roessler, Yang-Zhu Du, Jose L Mullor, Esther Casas, William P Allen, Gabriele Gillessen-Kaesbach, Elizabeth R Roeder, Jeffrey E Ming, Ariel Ruiz i Altaba, Maximilian Muenke. Proc Natl Acad Sci U S A 2003
235
21

The molecular genetics of holoprosencephaly.
Erich Roessler, Maximilian Muenke. Am J Med Genet C Semin Med Genet 2010
153
20

Mutations in the homeodomain of the human SIX3 gene cause holoprosencephaly.
D E Wallis, E Roessler, U Hehr, L Nanni, T Wiltshire, A Richieri-Costa, G Gillessen-Kaesbach, E H Zackai, J Rommens, M Muenke. Nat Genet 1999
283
16

The mechanisms of Hedgehog signalling and its roles in development and disease.
James Briscoe, Pascal P Thérond. Nat Rev Mol Cell Biol 2013
928
15

The mutational spectrum of the sonic hedgehog gene in holoprosencephaly: SHH mutations cause a significant proportion of autosomal dominant holoprosencephaly.
L Nanni, J E Ming, M Bocian, K Steinhaus, D W Bianchi, C Die-Smulders, A Giannotti, K Imaizumi, K L Jones, M D Campo,[...]. Hum Mol Genet 1999
258
14

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity.
Y Echelard, D J Epstein, B St-Jacques, L Shen, J Mohler, J A McMahon, A P McMahon. Cell 1993
14


Holoprosencephaly due to mutations in ZIC2, a homologue of Drosophila odd-paired.
S A Brown, D Warburton, L Y Brown, C Y Yu, E R Roeder, S Stengel-Rutkowski, R C Hennekam, M Muenke. Nat Genet 1998
365
13

Genotypic and phenotypic analysis of 396 individuals with mutations in Sonic Hedgehog.
Benjamin D Solomon, Kelly A Bear, Adrian Wyllie, Amelia A Keaton, Christele Dubourg, Veronique David, Sandra Mercier, Sylvie Odent, Ute Hehr, Aimee Paulussen,[...]. J Med Genet 2012
50
26

Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination.
K W Gripp, D Wotton, M C Edwards, E Roessler, L Ades, P Meinecke, A Richieri-Costa, E H Zackai, J Massagué, M Muenke,[...]. Nat Genet 2000
299
13

Patched1 regulates hedgehog signaling at the primary cilium.
Rajat Rohatgi, Ljiljana Milenkovic, Matthew P Scott. Science 2007
933
13

Mutational Spectrum in Holoprosencephaly Shows That FGF is a New Major Signaling Pathway.
Christèle Dubourg, Wilfrid Carré, Houda Hamdi-Rozé, Charlotte Mouden, Joëlle Roume, Benmansour Abdelmajid, Daniel Amram, Clarisse Baumann, Nicolas Chassaing, Christine Coubes,[...]. Hum Mutat 2016
38
34

Truncating loss-of-function mutations of DISP1 contribute to holoprosencephaly-like microform features in humans.
Erich Roessler, Yong Ma, Maia V Ouspenskaia, Felicitas Lacbawan, Claude Bendavid, Christèle Dubourg, Philip A Beachy, Maximilian Muenke. Hum Genet 2009
49
24

Vertebrate Smoothened functions at the primary cilium.
Kevin C Corbit, Pia Aanstad, Veena Singla, Andrew R Norman, Didier Y R Stainier, Jeremy F Reiter. Nature 2005
986
12

Mutations affecting segment number and polarity in Drosophila.
C Nüsslein-Volhard, E Wieschaus. Nature 1980
12

New findings for phenotype-genotype correlations in a large European series of holoprosencephaly cases.
Sandra Mercier, Christèle Dubourg, Nicolas Garcelon, Boris Campillo-Gimenez, Isabelle Gicquel, Marion Belleguic, Leslie Ratié, Laurent Pasquier, Philippe Loget, Claude Bendavid,[...]. J Med Genet 2011
75
14

Mutations in PATCHED-1, the receptor for SONIC HEDGEHOG, are associated with holoprosencephaly.
Jeffrey E Ming, Michelle E Kaupas, Erich Roessler, Han G Brunner, Mahin Golabi, Mustafa Tekin, Robert F Stratton, Eva Sujansky, Sherri J Bale, Maximilian Muenke. Hum Genet 2002
158
11

Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors.
Gyu-Un Bae, Sabina Domené, Erich Roessler, Karen Schachter, Jong-Sun Kang, Maximilian Muenke, Robert S Krauss. Am J Hum Genet 2011
90
12

Hedgehog signalling in the mouse requires intraflagellar transport proteins.
Danwei Huangfu, Aimin Liu, Andrew S Rakeman, Noel S Murcia, Lee Niswander, Kathryn V Anderson. Nature 2003
953
11

The teratogenic effects of prenatal ethanol exposure are exacerbated by Sonic Hedgehog or GLI2 haploinsufficiency in the mouse.
Henry W Kietzman, Joshua L Everson, Kathleen K Sulik, Robert J Lipinski. PLoS One 2014
71
15

Genetics of ventral forebrain development and holoprosencephaly.
M Muenke, P A Beachy. Curr Opin Genet Dev 2000
196
11

Analysis of genotype-phenotype correlations in human holoprosencephaly.
Benjamin D Solomon, Sandra Mercier, Jorge I Vélez, Daniel E Pineda-Alvarez, Adrian Wyllie, Nan Zhou, Christèle Dubourg, Veronique David, Sylvie Odent, Erich Roessler,[...]. Am J Med Genet C Semin Med Genet 2010
106
11



The primary cilium: a signalling centre during vertebrate development.
Sarah C Goetz, Kathryn V Anderson. Nat Rev Genet 2010
10


Hedgehog: functions and mechanisms.
Markku Varjosalo, Jussi Taipale. Genes Dev 2008
809
10

Holoprosencephaly.
Christèle Dubourg, Claude Bendavid, Laurent Pasquier, Catherine Henry, Sylvie Odent, Véronique David. Orphanet J Rare Dis 2007
219
10

Mutations in ZIC2 in human holoprosencephaly: description of a novel ZIC2 specific phenotype and comprehensive analysis of 157 individuals.
Benjamin D Solomon, Felicitas Lacbawan, Sandra Mercier, Nancy J Clegg, Mauricio R Delgado, Kenneth Rosenbaum, Christèle Dubourg, Veronique David, Ann Haskins Olney, Lars-Erik Wehner,[...]. J Med Genet 2010
57
15


Human homolog of patched, a candidate gene for the basal cell nevus syndrome.
R L Johnson, A L Rothman, J Xie, L V Goodrich, J W Bare, J M Bonifas, A G Quinn, R M Myers, D R Cox, E H Epstein,[...]. Science 1996
9

Activating Smoothened mutations in sporadic basal-cell carcinoma.
J Xie, M Murone, S M Luoh, A Ryan, Q Gu, C Zhang, J M Bonifas, C W Lam, M Hynes, A Goddard,[...]. Nature 1998
979
9


Definition of critical periods for Hedgehog pathway antagonist-induced holoprosencephaly, cleft lip, and cleft palate.
Galen W Heyne, Cal G Melberg, Padydeh Doroodchi, Kia F Parins, Henry W Kietzman, Joshua L Everson, Lydia J Ansen-Wilson, Robert J Lipinski. PLoS One 2015
35
25

Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia.
Juhee Jeong, Junhao Mao, Toyoaki Tenzen, Andreas H Kottmann, Andrew P McMahon. Genes Dev 2004
415
9

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.
Giovanni Luchetti, Ria Sircar, Jennifer H Kong, Sigrid Nachtergaele, Andreas Sagner, Eamon Fx Byrne, Douglas F Covey, Christian Siebold, Rajat Rohatgi. Elife 2016
119
9

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.
James K Chen, Jussi Taipale, Michael K Cooper, Philip A Beachy. Genes Dev 2002
9

BOC is a modifier gene in holoprosencephaly.
Mingi Hong, Kshitij Srivastava, Sungjin Kim, Benjamin L Allen, Daniel J Leahy, Ping Hu, Erich Roessler, Robert S Krauss, Maximilian Muenke. Hum Mutat 2017
16
56

A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis.
Michael K Cooper, Christopher A Wassif, Patrycja A Krakowiak, Jussi Taipale, Ruoyu Gong, Richard I Kelley, Forbes D Porter, Philip A Beachy. Nat Genet 2003
274
9

A Hypomorphic Allele in the FGF8 Gene Contributes to Holoprosencephaly and Is Allelic to Gonadotropin-Releasing Hormone Deficiency in Humans.
R F Arauz, B D Solomon, D E Pineda-Alvarez, A L Gropman, J A Parsons, E Roessler, M Muenke. Mol Syndromol 2010
37
21

Mutations in the C-terminal domain of Sonic Hedgehog cause holoprosencephaly.
E Roessler, E Belloni, K Gaudenz, F Vargas, S W Scherer, L C Tsui, M Muenke. Hum Mol Genet 1997
130
8

Reduced NODAL signaling strength via mutation of several pathway members including FOXH1 is linked to human heart defects and holoprosencephaly.
Erich Roessler, Maia V Ouspenskaia, Jayaprakash D Karkera, Jorge I Vélez, Amy Kantipong, Felicitas Lacbawan, Peter Bowers, John W Belmont, Jeffrey A Towbin, Elizabeth Goldmuntz,[...]. Am J Hum Genet 2008
101
8

LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals.
Annabel Christ, Anna Christa, Esther Kur, Oleg Lioubinski, Sebastian Bachmann, Thomas E Willnow, Annette Hammes. Dev Cell 2012
65
12

Clinical characterization of individuals with deletions of genes in holoprosencephaly pathways by aCGH refines the phenotypic spectrum of HPE.
Jill A Rosenfeld, Blake C Ballif, Donna M Martin, Arthur S Aylsworth, Bassem A Bejjani, Beth S Torchia, Lisa G Shaffer. Hum Genet 2010
49
16


Patched acts catalytically to suppress the activity of Smoothened.
J Taipale, M K Cooper, T Maiti, P A Beachy. Nature 2002
569
8


Fetal ethanol exposure activates protein kinase A and impairs Shh expression in prechordal mesendoderm cells in the pathogenesis of holoprosencephaly.
Kazushi Aoto, Yayoi Shikata, Daisuke Higashiyama, Kohei Shiota, Jun Motoyama. Birth Defects Res A Clin Mol Teratol 2008
74
10


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.