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Times Cited: 971
Times Cited: 971
Times Cited
Times Co-cited
Similarity
Shelterin: the protein complex that shapes and safeguards human telomeres.
Titia de Lange. Genes Dev 2005
Titia de Lange. Genes Dev 2005
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Control of human telomere length by TRF1 and TRF2.
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Mammalian telomeres end in a large duplex loop.
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TRF2 protects human telomeres from end-to-end fusions.
B van Steensel, A Smogorzewska, T de Lange. Cell 1998
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Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication.
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Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.
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TIN2, a new regulator of telomere length in human cells.
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Diego Loayza, Titia De Lange. Nature 2003
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Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation.
Ylli Doksani, John Y Wu, Titia de Lange, Xiaowei Zhuang. Cell 2013
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The POT1-TPP1 telomere complex is a telomerase processivity factor.
Feng Wang, Elaine R Podell, Arthur J Zaug, Yuting Yang, Paul Baciu, Thomas R Cech, Ming Lei. Nature 2007
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Pot1, the putative telomere end-binding protein in fission yeast and humans.
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Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2.
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The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.
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A DNA damage checkpoint response in telomere-initiated senescence.
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Telomeres shorten during ageing of human fibroblasts.
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Removal of shelterin reveals the telomere end-protection problem.
Agnel Sfeir, Titia de Lange. Science 2012
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DNA damage foci at dysfunctional telomeres.
Hiroyuki Takai, Agata Smogorzewska, Titia de Lange. Curr Biol 2003
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POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex.
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TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.
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TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends.
Franklin L Zhong, Luis F Z Batista, Adam Freund, Matthew F Pech, Andrew S Venteicher, Steven E Artandi. Cell 2012
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PTOP interacts with POT1 and regulates its localization to telomeres.
Dan Liu, Amin Safari, Matthew S O'Connor, Doug W Chan, Andrew Laegeler, Jun Qin, Zhou Songyang. Nat Cell Biol 2004
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Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends.
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TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase.
Huawei Xin, Dan Liu, Ma Wan, Amin Safari, Hyeung Kim, Wen Sun, Matthew S O'Connor, Zhou Songyang. Nature 2007
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TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo.
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T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang.
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Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice.
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A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
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A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly.
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p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2.
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Telomere protection by TPP1/POT1 requires tethering to TIN2.
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Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres.
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Identification of human Rap1: implications for telomere evolution.
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Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2.
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Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites.
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Telomeres in cancer: tumour suppression and genome instability.
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Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.