Y M Lu, Z Jia, C Janus, J T Henderson, R Gerlai, J M Wojtowicz, J C Roder. J Neurosci 1997
Times Cited: 493
Times Cited: 493
Times Cited
Times Co-cited
Similarity
mGluR5 has a critical role in inhibitory learning.
Jian Xu, Yongling Zhu, Anis Contractor, Stephen F Heinemann. J Neurosci 2009
Jian Xu, Yongling Zhu, Anis Contractor, Stephen F Heinemann. J Neurosci 2009
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Metabotropic glutamate receptors: physiology, pharmacology, and disease.
Colleen M Niswender, P Jeffrey Conn. Annu Rev Pharmacol Toxicol 2010
Colleen M Niswender, P Jeffrey Conn. Annu Rev Pharmacol Toxicol 2010
24
The metabotropic glutamate receptor, mGluR5, is a key determinant of good and bad spatial learning performance and hippocampal synaptic plasticity.
Denise Manahan-Vaughan, Karl-Heinz Braunewell. Cereb Cortex 2005
Denise Manahan-Vaughan, Karl-Heinz Braunewell. Cereb Cortex 2005
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Selective abolition of the NMDA component of long-term potentiation in mice lacking mGluR5.
Z Jia, Y Lu, J Henderson, F Taverna, C Romano, W Abramow-Newerly, J M Wojtowicz, J Roder. Learn Mem 1998
Z Jia, Y Lu, J Henderson, F Taverna, C Romano, W Abramow-Newerly, J M Wojtowicz, J Roder. Learn Mem 1998
17
Group 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and disease.
Christian Lüscher, Kimberly M Huber. Neuron 2010
Christian Lüscher, Kimberly M Huber. Neuron 2010
16
mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning.
Jennifer E Ayala, Yelin Chen, Jessica L Banko, Douglas J Sheffler, Richard Williams, Alexandra N Telk, Noreen L Watson, Zixiu Xiang, Yongqin Zhang, Paulianda J Jones,[...]. Neuropsychopharmacology 2009
Jennifer E Ayala, Yelin Chen, Jessica L Banko, Douglas J Sheffler, Richard Williams, Alexandra N Telk, Noreen L Watson, Zixiu Xiang, Yongqin Zhang, Paulianda J Jones,[...]. Neuropsychopharmacology 2009
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Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function.
G Mannaioni, M J Marino, O Valenti, S F Traynelis, P J Conn. J Neurosci 2001
G Mannaioni, M J Marino, O Valenti, S F Traynelis, P J Conn. J Neurosci 2001
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Metabotropic glutamate receptor 5 knockout reduces cognitive impairment and pathogenesis in a mouse model of Alzheimer's disease.
Alison Hamilton, Jessica L Esseltine, Rebecca A DeVries, Sean P Cregan, Stephen S G Ferguson. Mol Brain 2014
Alison Hamilton, Jessica L Esseltine, Rebecca A DeVries, Sean P Cregan, Stephen S G Ferguson. Mol Brain 2014
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Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins.
J C Tu, B Xiao, S Naisbitt, J P Yuan, R S Petralia, P Brakeman, A Doan, V K Aakalu, A A Lanahan, M Sheng,[...]. Neuron 1999
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Metabotropic glutamate receptors: from the workbench to the bedside.
F Nicoletti, J Bockaert, G L Collingridge, P J Conn, F Ferraguti, D D Schoepp, J T Wroblewski, J P Pin. Neuropharmacology 2011
F Nicoletti, J Bockaert, G L Collingridge, P J Conn, F Ferraguti, D D Schoepp, J T Wroblewski, J P Pin. Neuropharmacology 2011
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Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression.
K M Huber, M S Kayser, M F Bear. Science 2000
K M Huber, M S Kayser, M F Bear. Science 2000
12
Clozapine reverses schizophrenia-related behaviours in the metabotropic glutamate receptor 5 knockout mouse: association with N-methyl-D-aspartic acid receptor up-regulation.
Laura Gray, Maarten van den Buuse, Elizabeth Scarr, Brian Dean, Anthony J Hannan. Int J Neuropsychopharmacol 2009
Laura Gray, Maarten van den Buuse, Elizabeth Scarr, Brian Dean, Anthony J Hannan. Int J Neuropsychopharmacol 2009
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Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain.
R Shigemoto, S Nomura, H Ohishi, H Sugihara, S Nakanishi, N Mizuno. Neurosci Lett 1993
R Shigemoto, S Nomura, H Ohishi, H Sugihara, S Nakanishi, N Mizuno. Neurosci Lett 1993
11
Altered synaptic plasticity in a mouse model of fragile X mental retardation.
Kimberly M Huber, Sean M Gallagher, Stephen T Warren, Mark F Bear. Proc Natl Acad Sci U S A 2002
Kimberly M Huber, Sean M Gallagher, Stephen T Warren, Mark F Bear. Proc Natl Acad Sci U S A 2002
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The mGluR theory of fragile X mental retardation.
Mark F Bear, Kimberly M Huber, Stephen T Warren. Trends Neurosci 2004
Mark F Bear, Kimberly M Huber, Stephen T Warren. Trends Neurosci 2004
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Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodents.
Gene G Kinney, Maryann Burno, Una C Campbell, Lisa M Hernandez, Dana Rodriguez, Linda J Bristow, P Jeffrey Conn. J Pharmacol Exp Ther 2003
Gene G Kinney, Maryann Burno, Una C Campbell, Lisa M Hernandez, Dana Rodriguez, Linda J Bristow, P Jeffrey Conn. J Pharmacol Exp Ther 2003
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Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein.
Ji Won Um, Adam C Kaufman, Mikhail Kostylev, Jacqueline K Heiss, Massimiliano Stagi, Hideyuki Takahashi, Meghan E Kerrisk, Alexander Vortmeyer, Thomas Wisniewski, Anthony J Koleske,[...]. Neuron 2013
Ji Won Um, Adam C Kaufman, Mikhail Kostylev, Jacqueline K Heiss, Massimiliano Stagi, Hideyuki Takahashi, Meghan E Kerrisk, Alexander Vortmeyer, Thomas Wisniewski, Anthony J Koleske,[...]. Neuron 2013
11
Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1.
F Conquet, Z I Bashir, C H Davies, H Daniel, F Ferraguti, F Bordi, K Franz-Bacon, A Reggiani, V Matarese, F Condé. Nature 1994
F Conquet, Z I Bashir, C H Davies, H Daniel, F Ferraguti, F Bordi, K Franz-Bacon, A Reggiani, V Matarese, F Condé. Nature 1994
11
Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampus.
R Lujan, Z Nusser, J D Roberts, R Shigemoto, P Somogyi. Eur J Neurosci 1996
R Lujan, Z Nusser, J D Roberts, R Shigemoto, P Somogyi. Eur J Neurosci 1996
11
Correction of fragile X syndrome in mice.
Gül Dölen, Emily Osterweil, B S Shankaranarayana Rao, Gordon B Smith, Benjamin D Auerbach, Sumantra Chattarji, Mark F Bear. Neuron 2007
Gül Dölen, Emily Osterweil, B S Shankaranarayana Rao, Gordon B Smith, Benjamin D Auerbach, Sumantra Chattarji, Mark F Bear. Neuron 2007
10
Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5.
Marianne Renner, Pascale N Lacor, Pauline T Velasco, Jian Xu, Anis Contractor, William L Klein, Antoine Triller. Neuron 2010
Marianne Renner, Pascale N Lacor, Pauline T Velasco, Jian Xu, Anis Contractor, William L Klein, Antoine Triller. Neuron 2010
10
Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice.
C Chiamulera, M P Epping-Jordan, A Zocchi, C Marcon, C Cottiny, S Tacconi, M Corsi, F Orzi, F Conquet. Nat Neurosci 2001
C Chiamulera, M P Epping-Jordan, A Zocchi, C Marcon, C Cottiny, S Tacconi, M Corsi, F Orzi, F Conquet. Nat Neurosci 2001
9
Assessment of a prepulse inhibition deficit in a mutant mouse lacking mGlu5 receptors.
S A Brody, S C Dulawa, F Conquet, M A Geyer. Mol Psychiatry 2004
S A Brody, S C Dulawa, F Conquet, M A Geyer. Mol Psychiatry 2004
9
Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia.
P Jeffrey Conn, Craig W Lindsley, Carrie K Jones. Trends Pharmacol Sci 2009
P Jeffrey Conn, Craig W Lindsley, Carrie K Jones. Trends Pharmacol Sci 2009
9
Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents.
Jerri M Rook, Zixiu Xiang, Xiaohui Lv, Ayan Ghoshal, Jonathan W Dickerson, Thomas M Bridges, Kari A Johnson, Daniel J Foster, Karen J Gregory, Paige N Vinson,[...]. Neuron 2015
Jerri M Rook, Zixiu Xiang, Xiaohui Lv, Ayan Ghoshal, Jonathan W Dickerson, Thomas M Bridges, Kari A Johnson, Daniel J Foster, Karen J Gregory, Paige N Vinson,[...]. Neuron 2015
10
Chemical induction of mGluR5- and protein synthesis--dependent long-term depression in hippocampal area CA1.
K M Huber, J C Roder, M F Bear. J Neurophysiol 2001
K M Huber, J C Roder, M F Bear. J Neurophysiol 2001
9
Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro.
Sergey Neyman, Denise Manahan-Vaughan. Eur J Neurosci 2008
Sergey Neyman, Denise Manahan-Vaughan. Eur J Neurosci 2008
9
mGluR5 ablation in cortical glutamatergic neurons increases novelty-induced locomotion.
Chris P Jew, Chia-Shan Wu, Hao Sun, Jie Zhu, Jui-Yen Huang, Dinghui Yu, Nicholas J Justice, Hui-Chen Lu. PLoS One 2013
Chris P Jew, Chia-Shan Wu, Hao Sun, Jie Zhu, Jui-Yen Huang, Dinghui Yu, Nicholas J Justice, Hui-Chen Lu. PLoS One 2013
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mGluR5 and NMDA receptors drive the experience- and activity-dependent NMDA receptor NR2B to NR2A subunit switch.
Jose A Matta, Michael C Ashby, Antonio Sanz-Clemente, Katherine W Roche, John T R Isaac. Neuron 2011
Jose A Matta, Michael C Ashby, Antonio Sanz-Clemente, Katherine W Roche, John T R Isaac. Neuron 2011
8
The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in rats.
Una C Campbell, Kush Lalwani, Lisa Hernandez, Gene G Kinney, P Jeffrey Conn, Linda J Bristow. Psychopharmacology (Berl) 2004
Una C Campbell, Kush Lalwani, Lisa Hernandez, Gene G Kinney, P Jeffrey Conn, Linda J Bristow. Psychopharmacology (Berl) 2004
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Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus.
H Awad, G W Hubert, Y Smith, A I Levey, P J Conn. J Neurosci 2000
H Awad, G W Hubert, Y Smith, A I Levey, P J Conn. J Neurosci 2000
8
Long-term depression in the CNS.
Graham L Collingridge, Stephane Peineau, John G Howland, Yu Tian Wang. Nat Rev Neurosci 2010
Graham L Collingridge, Stephane Peineau, John G Howland, Yu Tian Wang. Nat Rev Neurosci 2010
8
Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain.
C Romano, M A Sesma, C T McDonald, K O'Malley, A N Van den Pol, J W Olney. J Comp Neurol 1995
C Romano, M A Sesma, C T McDonald, K O'Malley, A N Van den Pol, J W Olney. J Comp Neurol 1995
8
Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice.
Aubin Michalon, Michael Sidorov, Theresa M Ballard, Laurence Ozmen, Will Spooren, Joseph G Wettstein, Georg Jaeschke, Mark F Bear, Lothar Lindemann. Neuron 2012
Aubin Michalon, Michael Sidorov, Theresa M Ballard, Laurence Ozmen, Will Spooren, Joseph G Wettstein, Georg Jaeschke, Mark F Bear, Lothar Lindemann. Neuron 2012
8
A synaptic model of memory: long-term potentiation in the hippocampus.
T V Bliss, G L Collingridge. Nature 1993
T V Bliss, G L Collingridge. Nature 1993
8
The metabotropic glutamate receptor 5 is necessary for late-phase long-term potentiation in the hippocampal CA1 region.
Walter Francesconi, Maurizio Cammalleri, Pietro Paolo Sanna. Brain Res 2004
Walter Francesconi, Maurizio Cammalleri, Pietro Paolo Sanna. Brain Res 2004
15
Norbin is an endogenous regulator of metabotropic glutamate receptor 5 signaling.
Hong Wang, Linda Westin, Yi Nong, Shari Birnbaum, Jacob Bendor, Hjalmar Brismar, Eric Nestler, Anita Aperia, Marc Flajolet, Paul Greengard. Science 2009
Hong Wang, Linda Westin, Yi Nong, Shari Birnbaum, Jacob Bendor, Hjalmar Brismar, Eric Nestler, Anita Aperia, Marc Flajolet, Paul Greengard. Science 2009
9
The regulation of hippocampal LTP by the molecular switch, a form of metaplasticity, requires mGlu5 receptors.
Zuner A Bortolotto, Valerie J Collett, Francois Conquet, Zhengping Jia, Herman van der Putten, Graham L Collingridge. Neuropharmacology 2005
Zuner A Bortolotto, Valerie J Collett, Francois Conquet, Zhengping Jia, Herman van der Putten, Graham L Collingridge. Neuropharmacology 2005
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Disruption of mGluR5 in parvalbumin-positive interneurons induces core features of neurodevelopmental disorders.
S A Barnes, A Pinto-Duarte, A Kappe, A Zembrzycki, A Metzler, E A Mukamel, J Lucero, X Wang, T J Sejnowski, A Markou,[...]. Mol Psychiatry 2015
S A Barnes, A Pinto-Duarte, A Kappe, A Zembrzycki, A Metzler, E A Mukamel, J Lucero, X Wang, T J Sejnowski, A Markou,[...]. Mol Psychiatry 2015
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Two distinct signaling pathways upregulate NMDA receptor responses via two distinct metabotropic glutamate receptor subtypes.
Pascal Benquet, Christine E Gee, Urs Gerber. J Neurosci 2002
Pascal Benquet, Christine E Gee, Urs Gerber. J Neurosci 2002
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mGluR5, but not mGluR1, antagonist modifies MK-801-induced locomotor activity and deficit of prepulse inhibition.
M Pietraszek, A Gravius, D Schäfer, T Weil, D Trifanova, W Danysz. Neuropharmacology 2005
M Pietraszek, A Gravius, D Schäfer, T Weil, D Trifanova, W Danysz. Neuropharmacology 2005
9
7
Dysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with Intellectual Disability and Autism.
Simona D'Antoni, Michela Spatuzza, Carmela M Bonaccorso, Sebastiano A Musumeci, Lucia Ciranna, Ferdinando Nicoletti, Kimberly M Huber, Maria Vincenza Catania. Neurosci Biobehav Rev 2014
Simona D'Antoni, Michela Spatuzza, Carmela M Bonaccorso, Sebastiano A Musumeci, Lucia Ciranna, Ferdinando Nicoletti, Kimberly M Huber, Maria Vincenza Catania. Neurosci Biobehav Rev 2014
11
Mutations causing syndromic autism define an axis of synaptic pathophysiology.
Benjamin D Auerbach, Emily K Osterweil, Mark F Bear. Nature 2011
Benjamin D Auerbach, Emily K Osterweil, Mark F Bear. Nature 2011
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Memory for fear extinction requires mGluR5-mediated activation of infralimbic neurons.
Darah E Fontanez-Nuin, Edwin Santini, Gregory J Quirk, James T Porter. Cereb Cortex 2011
Darah E Fontanez-Nuin, Edwin Santini, Gregory J Quirk, James T Porter. Cereb Cortex 2011
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The group I mGlu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus.
M J Palmer, A J Irving, G R Seabrook, D E Jane, G L Collingridge. Neuropharmacology 1997
M J Palmer, A J Irving, G R Seabrook, D E Jane, G L Collingridge. Neuropharmacology 1997
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Group 1 metabotropic glutamate receptor function and its regulation of learning and memory in the aging brain.
Caroline Ménard, Rémi Quirion. Front Pharmacol 2012
Caroline Ménard, Rémi Quirion. Front Pharmacol 2012
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Enhanced early developmental expression of the metabotropic glutamate receptor mGluR5 in rat brain: protein, mRNA splice variants, and regional distribution.
C Romano, A N van den Pol, K L O'Malley. J Comp Neurol 1996
C Romano, A N van den Pol, K L O'Malley. J Comp Neurol 1996
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Alterations in metabotropic glutamate receptor 1α and regulator of G protein signaling 4 in the prefrontal cortex in schizophrenia.
David W Volk, Stephen M Eggan, David A Lewis. Am J Psychiatry 2010
David W Volk, Stephen M Eggan, David A Lewis. Am J Psychiatry 2010
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Functional Interaction Between NMDA and mGlu5 Receptors: Effects on Working Memory, Instrumental Learning, Motor Behaviors, and Dopamine Release.
Houman Homayoun, Mark R Stefani, Barbara W Adams, Gilles D Tamagan, Bita Moghaddam. Neuropsychopharmacology 2004
Houman Homayoun, Mark R Stefani, Barbara W Adams, Gilles D Tamagan, Bita Moghaddam. Neuropsychopharmacology 2004
7
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.