A citation-based method for searching scientific literature

V Gorboulev, J C Ulzheimer, A Akhoundova, I Ulzheimer-Teuber, U Karbach, S Quester, C Baumann, F Lang, A E Busch, H Koepsell. DNA Cell Biol 1997
Times Cited: 502







List of co-cited articles
1361 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity



Membrane transporters in drug development.
Kathleen M Giacomini, Shiew-Mei Huang, Donald J Tweedie, Leslie Z Benet, Kim L R Brouwer, Xiaoyan Chu, Amber Dahlin, Raymond Evers, Volker Fischer, Kathleen M Hillgren,[...]. Nat Rev Drug Discov 2010
32

Gene expression levels and immunolocalization of organic ion transporters in the human kidney.
Hideyuki Motohashi, Yuji Sakurai, Hideyuki Saito, Satohiro Masuda, Yumiko Urakami, Maki Goto, Atsushi Fukatsu, Osamu Ogawa, Ken-Ichi Inui. J Am Soc Nephrol 2002
384
32

Cloning and functional expression of a human liver organic cation transporter.
L Zhang, M J Dresser, A T Gray, S C Yost, S Terashita, K M Giacomini. Mol Pharmacol 1997
311
30

Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy.
Anne T Nies, Hermann Koepsell, Katja Damme, Matthias Schwab. Handb Exp Pharmacol 2011
266
29

Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver.
Anne T Nies, Hermann Koepsell, Stefan Winter, Oliver Burk, Kathrin Klein, Reinhold Kerb, Ulrich M Zanger, Dietrich Keppler, Matthias Schwab, Elke Schaeffeler. Hepatology 2009
267
27

Drug excretion mediated by a new prototype of polyspecific transporter.
D Gründemann, V Gorboulev, S Gambaryan, M Veyhl, H Koepsell. Nature 1994
544
24

OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.
Ligong Chen, Yan Shu, Xiaomin Liang, Eugene C Chen, Sook Wah Yee, Arik A Zur, Shuanglian Li, Lu Xu, Kayvan R Keshari, Michael J Lin,[...]. Proc Natl Acad Sci U S A 2014
139
24

Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action.
Yan Shu, Steven A Sheardown, Chaline Brown, Ryan P Owen, Shuzhong Zhang, Richard A Castro, Alexandra G Ianculescu, Lin Yue, Joan C Lo, Esteban G Burchard,[...]. J Clin Invest 2007
615
23

Morphine is a substrate of the organic cation transporter OCT1 and polymorphisms in OCT1 gene affect morphine pharmacokinetics after codeine administration.
Mladen V Tzvetkov, Joao N dos Santos Pereira, Ingolf Meineke, Ali R Saadatmand, Julia C Stingl, Jürgen Brockmöller. Biochem Pharmacol 2013
125
23


Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine.
A E Busch, U Karbach, D Miska, V Gorboulev, A Akhoundova, C Volk, P Arndt, J C Ulzheimer, M S Sonders, C Baumann,[...]. Mol Pharmacol 1998
258
20

Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium.
Katrin Susanne Lips, Christopher Volk, Bernhard Matthias Schmitt, Uwe Pfeil, Petra Arndt, Dagmar Miska, Leander Ermert, Wolfgang Kummer, Hermann Koepsell. Am J Respir Cell Mol Biol 2005
159
20

Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2.
Satohiro Masuda, Tomohiro Terada, Atsushi Yonezawa, Yuko Tanihara, Koshiro Kishimoto, Toshiya Katsura, Osamu Ogawa, Ken-ichi Inui. J Am Soc Nephrol 2006
262
20

Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Gustav Ahlin, Johan Karlsson, Jenny M Pedersen, Lena Gustavsson, Rolf Larsson, Pär Matsson, Ulf Norinder, Christel A S Bergström, Per Artursson. J Med Chem 2008
129
19

A human transporter protein that mediates the final excretion step for toxic organic cations.
Masato Otsuka, Takuya Matsumoto, Riyo Morimoto, Shigeo Arioka, Hiroshi Omote, Yoshinori Moriyama. Proc Natl Acad Sci U S A 2005
393
19

The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin.
M V Tzvetkov, S V Vormfelde, D Balen, I Meineke, T Schmidt, D Sehrt, I Sabolić, H Koepsell, J Brockmöller. Clin Pharmacol Ther 2009
223
19


Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1.
Yan Shu, Maya K Leabman, Bo Feng, Lara M Mangravite, Conrad C Huang, Doug Stryke, Michiko Kawamoto, Susan J Johns, Joseph DeYoung, Elaine Carlson,[...]. Proc Natl Acad Sci U S A 2003
213
18


Organic Cation Transporters in Health and Disease.
Hermann Koepsell. Pharmacol Rev 2020
96
18

Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions.
Giuliano Ciarimboli, Dirk Deuster, Arne Knief, Michael Sperling, Michael Holtkamp, Bayram Edemir, Hermann Pavenstädt, Claudia Lanvers-Kaminsky, Antoinette am Zehnhoff-Dinnesen, Alfred H Schinkel,[...]. Am J Pathol 2010
276
17

Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter.
D Gründemann, B Schechinger, G A Rappold, E Schömig. Nat Neurosci 1998
301
17

Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3.
Martina Hayer-Zillgen, Michael Brüss, Heinz Bönisch. Br J Pharmacol 2002
218
17

OCT1 mediates hepatic uptake of sumatriptan and loss-of-function OCT1 polymorphisms affect sumatriptan pharmacokinetics.
J Matthaei, D Kuron, F Faltraco, T Knoch, J N Dos Santos Pereira, M Abu Abed, T Prukop, J Brockmöller, M V Tzvetkov. Clin Pharmacol Ther 2016
58
29

Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences.
Reinhold Kerb, Ulrich Brinkmann, Natalia Chatskaia, Dmitry Gorbunov, Valentin Gorboulev, Esther Mornhinweg, Andrea Keil, Michel Eichelbaum, Hermann Koepsell. Pharmacogenetics 2002
154
17


Relevance of the organic cation transporters 1 and 2 for antiretroviral drug therapy in human immunodeficiency virus infection.
Norma Jung, Clara Lehmann, Andrea Rubbert, Meike Knispel, Pia Hartmann, Jan van Lunzen, Hans-Juergen Stellbrink, Gerd Faetkenheuer, Dirk Taubert. Drug Metab Dispos 2008
106
16

Effects of OCT1 polymorphisms on the cellular uptake, plasma concentrations and efficacy of the 5-HT(3) antagonists tropisetron and ondansetron.
M V Tzvetkov, A R Saadatmand, K Bokelmann, I Meineke, R Kaiser, J Brockmöller. Pharmacogenomics J 2012
103
16

Genetically polymorphic OCT1: another piece in the puzzle of the variable pharmacokinetics and pharmacodynamics of the opioidergic drug tramadol.
M V Tzvetkov, A R Saadatmand, J Lötsch, I Tegeder, J C Stingl, J Brockmöller. Clin Pharmacol Ther 2011
100
16


Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2.
Ramon Hendrickx, Jenny G Johansson, Christina Lohmann, Rose-Marie Jenvert, Anders Blomgren, Lena Börjesson, Lena Gustavsson. J Med Chem 2013
54
29

Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1).
Eugene C Chen, Natalia Khuri, Xiaomin Liang, Adrian Stecula, Huan-Chieh Chien, Sook Wah Yee, Yong Huang, Andrej Sali, Kathleen M Giacomini. J Med Chem 2017
31
51

Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1.
Naoko Kimura, Satohiro Masuda, Yuko Tanihara, Harumasa Ueo, Masahiro Okuda, Toshiya Katsura, Ken-Ichi Inui. Drug Metab Pharmacokinet 2005
245
15

Transport of lamivudine [(-)-beta-L-2',3'-dideoxy-3'-thiacytidine] and high-affinity interaction of nucleoside reverse transcriptase inhibitors with human organic cation transporters 1, 2, and 3.
Gerard Minuesa, Christopher Volk, Míriam Molina-Arcas, Valentin Gorboulev, Itziar Erkizia, Petra Arndt, Bonaventura Clotet, Marçal Pastor-Anglada, Hermann Koepsell, Javier Martinez-Picado. J Pharmacol Exp Ther 2009
104
15

Drug specificity and intestinal membrane localization of human organic cation transporters (OCT).
Johanna Müller, Katrin S Lips, Linda Metzner, Reinhard H H Neubert, Hermann Koepsell, Matthias Brandsch. Biochem Pharmacol 2005
171
15

Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters.
Yuko Tanihara, Satohiro Masuda, Tomoko Sato, Toshiya Katsura, Osamu Ogawa, Ken-Ichi Inui. Biochem Pharmacol 2007
272
15



Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1.
Tina Seitz, Robert Stalmann, Nawar Dalila, Jiayin Chen, Sherin Pojar, Joao N Dos Santos Pereira, Ralph Krätzner, Jürgen Brockmöller, Mladen V Tzvetkov. Genome Med 2015
61
22


Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity.
K K Filipski, R H Mathijssen, T S Mikkelsen, A H Schinkel, A Sparreboom. Clin Pharmacol Ther 2009
249
14

Substrate-dependent ligand inhibition of the human organic cation transporter OCT2.
Mathew Belzer, Mark Morales, Bhumasamudram Jagadish, Eugene A Mash, Stephen H Wright. J Pharmacol Exp Ther 2013
70
20


Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney.
X Wu, W Huang, M E Ganapathy, H Wang, R Kekuda, S J Conway, F H Leibach, V Ganapathy. Am J Physiol Renal Physiol 2000
123
13

Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2.
Giuliano Ciarimboli, Thomas Ludwig, Detlef Lang, Hermann Pavenstädt, Hermann Koepsell, Hans-Jürgen Piechota, Jörg Haier, Ulrich Jaehde, Jochen Zisowsky, Eberhard Schlatter. Am J Pathol 2005
283
13

Role of organic cation transporters in drug-drug interaction.
Hermann Koepsell. Expert Opin Drug Metab Toxicol 2015
58
22

Amino acids critical for substrate affinity of rat organic cation transporter 1 line the substrate binding region in a model derived from the tertiary structure of lactose permease.
Christian Popp, Valentin Gorboulev, Thomas D Müller, Dmitry Gorbunov, Natalia Shatskaya, Hermann Koepsell. Mol Pharmacol 2005
106
13

OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine.
Zhi-Jun Wang, Ophelia Q P Yin, Brian Tomlinson, Moses S S Chow. Pharmacogenet Genomics 2008
175
12

Interaction of antidepressant and antipsychotic drugs with the human organic cation transporters hOCT1, hOCT2 and hOCT3.
Britta Haenisch, Eva Drescher, Lidia Thiemer, Hu Xin, Bruno Giros, Sophie Gautron, Heinz Bönisch. Naunyn Schmiedebergs Arch Pharmacol 2012
33
36


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.