D Broccoli, A Smogorzewska, L Chong, T de Lange. Nat Genet 1997
Times Cited: 722
Times Cited: 722
Times Cited
Times Co-cited
Similarity
Shelterin: the protein complex that shapes and safeguards human telomeres.
Titia de Lange. Genes Dev 2005
Titia de Lange. Genes Dev 2005
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45
Mammalian telomeres end in a large duplex loop.
J D Griffith, L Comeau, S Rosenfield, R M Stansel, A Bianchi, H Moss, T de Lange. Cell 1999
J D Griffith, L Comeau, S Rosenfield, R M Stansel, A Bianchi, H Moss, T de Lange. Cell 1999
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Pot1, the putative telomere end-binding protein in fission yeast and humans.
P Baumann, T R Cech. Science 2001
P Baumann, T R Cech. Science 2001
40
Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication.
Agnel Sfeir, Settapong T Kosiyatrakul, Dirk Hockemeyer, Sheila L MacRae, Jan Karlseder, Carl L Schildkraut, Titia de Lange. Cell 2009
Agnel Sfeir, Settapong T Kosiyatrakul, Dirk Hockemeyer, Sheila L MacRae, Jan Karlseder, Carl L Schildkraut, Titia de Lange. Cell 2009
32
TIN2, a new regulator of telomere length in human cells.
S H Kim, P Kaminker, J Campisi. Nat Genet 1999
S H Kim, P Kaminker, J Campisi. Nat Genet 1999
31
TRF2 protects human telomeres from end-to-end fusions.
B van Steensel, A Smogorzewska, T de Lange. Cell 1998
B van Steensel, A Smogorzewska, T de Lange. Cell 1998
31
Identification of human Rap1: implications for telomere evolution.
B Li, S Oestreich, T de Lange. Cell 2000
B Li, S Oestreich, T de Lange. Cell 2000
31
Telomeric localization of TRF2, a novel human telobox protein.
T Bilaud, C Brun, K Ancelin, C E Koering, T Laroche, E Gilson. Nat Genet 1997
T Bilaud, C Brun, K Ancelin, C E Koering, T Laroche, E Gilson. Nat Genet 1997
31
Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation.
Ylli Doksani, John Y Wu, Titia de Lange, Xiaowei Zhuang. Cell 2013
Ylli Doksani, John Y Wu, Titia de Lange, Xiaowei Zhuang. Cell 2013
29
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.
Eros Lazzerini Denchi, Titia de Lange. Nature 2007
Eros Lazzerini Denchi, Titia de Lange. Nature 2007
29
POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex.
Jeffrey Zheng-Sheng Ye, Dirk Hockemeyer, Andrew N Krutchinsky, Diego Loayza, Sarah M Hooper, Brian T Chait, Titia de Lange. Genes Dev 2004
Jeffrey Zheng-Sheng Ye, Dirk Hockemeyer, Andrew N Krutchinsky, Diego Loayza, Sarah M Hooper, Brian T Chait, Titia de Lange. Genes Dev 2004
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DNA damage foci at dysfunctional telomeres.
Hiroyuki Takai, Agata Smogorzewska, Titia de Lange. Curr Biol 2003
Hiroyuki Takai, Agata Smogorzewska, Titia de Lange. Curr Biol 2003
27
The POT1-TPP1 telomere complex is a telomerase processivity factor.
Feng Wang, Elaine R Podell, Arthur J Zaug, Yuting Yang, Paul Baciu, Thomas R Cech, Ming Lei. Nature 2007
Feng Wang, Elaine R Podell, Arthur J Zaug, Yuting Yang, Paul Baciu, Thomas R Cech, Ming Lei. Nature 2007
27
A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
Yong Chen, Yuting Yang, Megan van Overbeek, Jill R Donigian, Paul Baciu, Titia de Lange, Ming Lei. Science 2008
Yong Chen, Yuting Yang, Megan van Overbeek, Jill R Donigian, Paul Baciu, Titia de Lange, Ming Lei. Science 2008
25
Removal of shelterin reveals the telomere end-protection problem.
Agnel Sfeir, Titia de Lange. Science 2012
Agnel Sfeir, Titia de Lange. Science 2012
25
TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.
Jeffrey Zheng-Sheng Ye, Jill R Donigian, Megan van Overbeek, Diego Loayza, Yan Luo, Andrew N Krutchinsky, Brian T Chait, Titia de Lange. J Biol Chem 2004
Jeffrey Zheng-Sheng Ye, Jill R Donigian, Megan van Overbeek, Diego Loayza, Yan Luo, Andrew N Krutchinsky, Brian T Chait, Titia de Lange. J Biol Chem 2004
24
PTOP interacts with POT1 and regulates its localization to telomeres.
Dan Liu, Amin Safari, Matthew S O'Connor, Doug W Chan, Andrew Laegeler, Jun Qin, Zhou Songyang. Nat Cell Biol 2004
Dan Liu, Amin Safari, Matthew S O'Connor, Doug W Chan, Andrew Laegeler, Jun Qin, Zhou Songyang. Nat Cell Biol 2004
24
A human telomeric protein.
L Chong, B van Steensel, D Broccoli, H Erdjument-Bromage, J Hanish, P Tempst, T de Lange. Science 1995
L Chong, B van Steensel, D Broccoli, H Erdjument-Bromage, J Hanish, P Tempst, T de Lange. Science 1995
24
A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2.
Benjamin R Houghtaling, Leanora Cuttonaro, William Chang, Susan Smith. Curr Biol 2004
Benjamin R Houghtaling, Leanora Cuttonaro, William Chang, Susan Smith. Curr Biol 2004
24
Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2.
L Fairall, L Chapman, H Moss, T de Lange, D Rhodes. Mol Cell 2001
L Fairall, L Chapman, H Moss, T de Lange, D Rhodes. Mol Cell 2001
23
A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly.
Matthew S O'Connor, Amin Safari, Huawei Xin, Dan Liu, Zhou Songyang. Proc Natl Acad Sci U S A 2006
Matthew S O'Connor, Amin Safari, Huawei Xin, Dan Liu, Zhou Songyang. Proc Natl Acad Sci U S A 2006
23
Identification of a specific telomere terminal transferase activity in Tetrahymena extracts.
C W Greider, E H Blackburn. Cell 1985
C W Greider, E H Blackburn. Cell 1985
23
TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection.
Delphine Benarroch-Popivker, Sabrina Pisano, Aaron Mendez-Bermudez, Liudmyla Lototska, Parminder Kaur, Serge Bauwens, Nadir Djerbi, Chrysa M Latrick, Vincent Fraisier, Bei Pei,[...]. Mol Cell 2016
Delphine Benarroch-Popivker, Sabrina Pisano, Aaron Mendez-Bermudez, Liudmyla Lototska, Parminder Kaur, Serge Bauwens, Nadir Djerbi, Chrysa M Latrick, Vincent Fraisier, Bei Pei,[...]. Mol Cell 2016
25
Control of human telomere length by TRF1 and TRF2.
A Smogorzewska, B van Steensel, A Bianchi, S Oelmann, M R Schaefer, G Schnapp, T de Lange. Mol Cell Biol 2000
A Smogorzewska, B van Steensel, A Bianchi, S Oelmann, M R Schaefer, G Schnapp, T de Lange. Mol Cell Biol 2000
21
Control of telomere length by the human telomeric protein TRF1.
B van Steensel, T de Lange. Nature 1997
B van Steensel, T de Lange. Nature 1997
21
Specific association of human telomerase activity with immortal cells and cancer.
N W Kim, M A Piatyszek, K R Prowse, C B Harley, M D West, P L Ho, G M Coviello, W E Wright, S L Weinrich, J W Shay. Science 1994
N W Kim, M A Piatyszek, K R Prowse, C B Harley, M D West, P L Ho, G M Coviello, W E Wright, S L Weinrich, J W Shay. Science 1994
21
TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase.
Huawei Xin, Dan Liu, Ma Wan, Amin Safari, Hyeung Kim, Wen Sun, Matthew S O'Connor, Zhou Songyang. Nature 2007
Huawei Xin, Dan Liu, Ma Wan, Amin Safari, Hyeung Kim, Wen Sun, Matthew S O'Connor, Zhou Songyang. Nature 2007
20
A DNA damage checkpoint response in telomere-initiated senescence.
Fabrizio d'Adda di Fagagna, Philip M Reaper, Lorena Clay-Farrace, Heike Fiegler, Philippa Carr, Thomas Von Zglinicki, Gabriele Saretzki, Nigel P Carter, Stephen P Jackson. Nature 2003
Fabrizio d'Adda di Fagagna, Philip M Reaper, Lorena Clay-Farrace, Heike Fiegler, Philippa Carr, Thomas Von Zglinicki, Gabriele Saretzki, Nigel P Carter, Stephen P Jackson. Nature 2003
20
Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends.
Claus M Azzalin, Patrick Reichenbach, Lela Khoriauli, Elena Giulotto, Joachim Lingner. Science 2007
Claus M Azzalin, Patrick Reichenbach, Lela Khoriauli, Elena Giulotto, Joachim Lingner. Science 2007
20
Telomere protection by TPP1/POT1 requires tethering to TIN2.
Kaori K Takai, Tatsuya Kibe, Jill R Donigian, David Frescas, Titia de Lange. Mol Cell 2011
Kaori K Takai, Tatsuya Kibe, Jill R Donigian, David Frescas, Titia de Lange. Mol Cell 2011
20
p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2.
J Karlseder, D Broccoli, Y Dai, S Hardy, T de Lange. Science 1999
J Karlseder, D Broccoli, Y Dai, S Hardy, T de Lange. Science 1999
19
A mammalian factor that binds telomeric TTAGGG repeats in vitro.
Z Zhong, L Shiue, S Kaplan, T de Lange. Mol Cell Biol 1992
Z Zhong, L Shiue, S Kaplan, T de Lange. Mol Cell Biol 1992
18
The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.
Jayakrishnan Nandakumar, Caitlin F Bell, Ina Weidenfeld, Arthur J Zaug, Leslie A Leinwand, Thomas R Cech. Nature 2012
Jayakrishnan Nandakumar, Caitlin F Bell, Ina Weidenfeld, Arthur J Zaug, Leslie A Leinwand, Thomas R Cech. Nature 2012
18
DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion.
Giulia B Celli, Titia de Lange. Nat Cell Biol 2005
Giulia B Celli, Titia de Lange. Nat Cell Biol 2005
17
Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection.
Ming Lei, Elaine R Podell, Thomas R Cech. Nat Struct Mol Biol 2004
Ming Lei, Elaine R Podell, Thomas R Cech. Nat Struct Mol Biol 2004
16
TRF1 is a dimer and bends telomeric DNA.
A Bianchi, S Smith, L Chong, P Elias, T de Lange. EMBO J 1997
A Bianchi, S Smith, L Chong, P Elias, T de Lange. EMBO J 1997
16
Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins.
Dan Liu, Matthew S O'Connor, Jun Qin, Zhou Songyang. J Biol Chem 2004
Dan Liu, Matthew S O'Connor, Jun Qin, Zhou Songyang. J Biol Chem 2004
16
T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang.
R M Stansel, T de Lange, J D Griffith. EMBO J 2001
R M Stansel, T de Lange, J D Griffith. EMBO J 2001
16
Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening.
V L Makarov, Y Hirose, J P Langmore. Cell 1997
V L Makarov, Y Hirose, J P Langmore. Cell 1997
15
POT1 as a terminal transducer of TRF1 telomere length control.
Diego Loayza, Titia De Lange. Nature 2003
Diego Loayza, Titia De Lange. Nature 2003
15
The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity.
C W Greider, E H Blackburn. Cell 1987
C W Greider, E H Blackburn. Cell 1987
15
Extension of life-span by introduction of telomerase into normal human cells.
A G Bodnar, M Ouellette, M Frolkis, S E Holt, C P Chiu, G B Morin, C B Harley, J W Shay, S Lichtsteiner, W E Wright. Science 1998
A G Bodnar, M Ouellette, M Frolkis, S E Holt, C P Chiu, G B Morin, C B Harley, J W Shay, S Lichtsteiner, W E Wright. Science 1998
15
How the human telomeric proteins TRF1 and TRF2 recognize telomeric DNA: a view from high-resolution crystal structures.
Robert Court, Lynda Chapman, Louise Fairall, Daniela Rhodes. EMBO Rep 2005
Robert Court, Lynda Chapman, Louise Fairall, Daniela Rhodes. EMBO Rep 2005
14
TRF1 binds a bipartite telomeric site with extreme spatial flexibility.
A Bianchi, R M Stansel, L Fairall, J D Griffith, D Rhodes, T de Lange. EMBO J 1999
A Bianchi, R M Stansel, L Fairall, J D Griffith, D Rhodes, T de Lange. EMBO J 1999
14
TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling.
Michal Zimmermann, Tatsuya Kibe, Shaheen Kabir, Titia de Lange. Genes Dev 2014
Michal Zimmermann, Tatsuya Kibe, Shaheen Kabir, Titia de Lange. Genes Dev 2014
14
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis.
C W Greider, E H Blackburn. Nature 1989
C W Greider, E H Blackburn. Nature 1989
14
TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo.
Eladio Abreu, Elena Aritonovska, Patrick Reichenbach, Gaël Cristofari, Brad Culp, Rebecca M Terns, Joachim Lingner, Michael P Terns. Mol Cell Biol 2010
Eladio Abreu, Elena Aritonovska, Patrick Reichenbach, Gaël Cristofari, Brad Culp, Rebecca M Terns, Joachim Lingner, Michael P Terns. Mol Cell Biol 2010
14
Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres.
Ling Wu, Asha S Multani, Hua He, Wilfredo Cosme-Blanco, Yu Deng, Jian Min Deng, Olga Bachilo, Sen Pathak, Hedioshi Tahara, Susan M Bailey,[...]. Cell 2006
Ling Wu, Asha S Multani, Hua He, Wilfredo Cosme-Blanco, Yu Deng, Jian Min Deng, Olga Bachilo, Sen Pathak, Hedioshi Tahara, Susan M Bailey,[...]. Cell 2006
14
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.