L de Lecea, T S Kilduff, C Peyron, X Gao, P E Foye, P E Danielson, C Fukuhara, E L Battenberg, V T Gautvik, F S Bartlett, W N Frankel, A N van den Pol, F E Bloom, K M Gautvik, J G Sutcliffe. Proc Natl Acad Sci U S A 1998
Times Cited: 2685
Times Cited: 2685
Times Cited
Times Co-cited
Similarity
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.
T Sakurai, A Amemiya, M Ishii, I Matsuzaki, R M Chemelli, H Tanaka, S C Williams, J A Richardson, G P Kozlowski, S Wilson,[...]. Cell 1998
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Differential expression of orexin receptors 1 and 2 in the rat brain.
J N Marcus, C J Aschkenasi, C E Lee, R M Chemelli, C B Saper, M Yanagisawa, J K Elmquist. J Comp Neurol 2001
J N Marcus, C J Aschkenasi, C E Lee, R M Chemelli, C B Saper, M Yanagisawa, J K Elmquist. J Comp Neurol 2001
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Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation.
R M Chemelli, J T Willie, C M Sinton, J K Elmquist, T Scammell, C Lee, J A Richardson, S C Williams, Y Xiong, Y Kisanuki,[...]. Cell 1999
R M Chemelli, J T Willie, C M Sinton, J K Elmquist, T Scammell, C Lee, J A Richardson, S C Williams, Y Xiong, Y Kisanuki,[...]. Cell 1999
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The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness.
Takeshi Sakurai. Nat Rev Neurosci 2007
Takeshi Sakurai. Nat Rev Neurosci 2007
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Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity.
J Hara, C T Beuckmann, T Nambu, J T Willie, R M Chemelli, C M Sinton, F Sugiyama, K Yagami, K Goto, M Yanagisawa,[...]. Neuron 2001
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Distribution of orexin neurons in the adult rat brain.
T Nambu, T Sakurai, K Mizukami, Y Hosoya, M Yanagisawa, K Goto. Brain Res 1999
T Nambu, T Sakurai, K Mizukami, Y Hosoya, M Yanagisawa, K Goto. Brain Res 1999
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Reduced number of hypocretin neurons in human narcolepsy.
T C Thannickal, R Y Moore, R Nienhuis, L Ramanathan, S Gulyani, M Aldrich, M Cornford, J M Siegel. Neuron 2000
T C Thannickal, R Y Moore, R Nienhuis, L Ramanathan, S Gulyani, M Aldrich, M Cornford, J M Siegel. Neuron 2000
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A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains.
C Peyron, J Faraco, W Rogers, B Ripley, S Overeem, Y Charnay, S Nevsimalova, M Aldrich, D Reynolds, R Albin,[...]. Nat Med 2000
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The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene.
L Lin, J Faraco, R Li, H Kadotani, W Rogers, X Lin, X Qiu, P J de Jong, S Nishino, E Mignot. Cell 1999
L Lin, J Faraco, R Li, H Kadotani, W Rogers, X Lin, X Qiu, P J de Jong, S Nishino, E Mignot. Cell 1999
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A role for lateral hypothalamic orexin neurons in reward seeking.
Glenda C Harris, Mathieu Wimmer, Gary Aston-Jones. Nature 2005
Glenda C Harris, Mathieu Wimmer, Gary Aston-Jones. Nature 2005
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Neurons containing hypocretin (orexin) project to multiple neuronal systems.
C Peyron, D K Tighe, A N van den Pol, L de Lecea, H C Heller, J G Sutcliffe, T S Kilduff. J Neurosci 1998
C Peyron, D K Tighe, A N van den Pol, L de Lecea, H C Heller, J G Sutcliffe, T S Kilduff. J Neurosci 1998
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Hypocretin (orexin) deficiency in human narcolepsy.
S Nishino, B Ripley, S Overeem, G J Lammers, E Mignot. Lancet 2000
S Nishino, B Ripley, S Overeem, G J Lammers, E Mignot. Lancet 2000
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Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems.
Y Date, Y Ueta, H Yamashita, H Yamaguchi, S Matsukura, K Kangawa, T Sakurai, M Yanagisawa, M Nakazato. Proc Natl Acad Sci U S A 1999
Y Date, Y Ueta, H Yamashita, H Yamaguchi, S Matsukura, K Kangawa, T Sakurai, M Yanagisawa, M Nakazato. Proc Natl Acad Sci U S A 1999
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Distribution of orexin receptor mRNA in the rat brain.
P Trivedi, H Yu, D J MacNeil, L H Van der Ploeg, X M Guan. FEBS Lett 1998
P Trivedi, H Yu, D J MacNeil, L H Van der Ploeg, X M Guan. FEBS Lett 1998
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Neural substrates of awakening probed with optogenetic control of hypocretin neurons.
Antoine R Adamantidis, Feng Zhang, Alexander M Aravanis, Karl Deisseroth, Luis de Lecea. Nature 2007
Antoine R Adamantidis, Feng Zhang, Alexander M Aravanis, Karl Deisseroth, Luis de Lecea. Nature 2007
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Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine.
Stephanie L Borgland, Sharif A Taha, Federica Sarti, Howard L Fields, Antonello Bonci. Neuron 2006
Stephanie L Borgland, Sharif A Taha, Federica Sarti, Howard L Fields, Antonello Bonci. Neuron 2006
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Motivational activation: a unifying hypothesis of orexin/hypocretin function.
Stephen V Mahler, David E Moorman, Rachel J Smith, Morgan H James, Gary Aston-Jones. Nat Neurosci 2014
Stephen V Mahler, David E Moorman, Rachel J Smith, Morgan H James, Gary Aston-Jones. Nat Neurosci 2014
12
A key role for orexin in panic anxiety.
Philip L Johnson, William Truitt, Stephanie D Fitz, Pamela E Minick, Amy Dietrich, Sonal Sanghani, Lil Träskman-Bendz, Andrew W Goddard, Lena Brundin, Anantha Shekhar. Nat Med 2010
Philip L Johnson, William Truitt, Stephanie D Fitz, Pamela E Minick, Amy Dietrich, Sonal Sanghani, Lil Träskman-Bendz, Andrew W Goddard, Lena Brundin, Anantha Shekhar. Nat Med 2010
12
Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes.
Jon T Willie, Richard M Chemelli, Christopher M Sinton, Shigeru Tokita, S Clay Williams, Yaz Y Kisanuki, Jacob N Marcus, Charlotte Lee, Joel K Elmquist, Kristi A Kohlmeier,[...]. Neuron 2003
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11
Anatomical substrates of orexin-dopamine interactions: lateral hypothalamic projections to the ventral tegmental area.
J Fadel, A Y Deutch. Neuroscience 2002
J Fadel, A Y Deutch. Neuroscience 2002
10
Afferents to the orexin neurons of the rat brain.
Kyoko Yoshida, Sarah McCormack, Rodrigo A España, Amanda Crocker, Thomas E Scammell. J Comp Neurol 2006
Kyoko Yoshida, Sarah McCormack, Rodrigo A España, Amanda Crocker, Thomas E Scammell. J Comp Neurol 2006
10
Hypocretin (orexin) loss in Alzheimer's disease.
Rolf Fronczek, Sarita van Geest, Marijke Frölich, Sebastiaan Overeem, Freek W C Roelandse, Gert Jan Lammers, Dick F Swaab. Neurobiol Aging 2012
Rolf Fronczek, Sarita van Geest, Marijke Frölich, Sebastiaan Overeem, Freek W C Roelandse, Gert Jan Lammers, Dick F Swaab. Neurobiol Aging 2012
10
Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle.
Jae-Eun Kang, Miranda M Lim, Randall J Bateman, James J Lee, Liam P Smyth, John R Cirrito, Nobuhiro Fujiki, Seiji Nishino, David M Holtzman. Science 2009
Jae-Eun Kang, Miranda M Lim, Randall J Bateman, James J Lee, Liam P Smyth, John R Cirrito, Nobuhiro Fujiki, Seiji Nishino, David M Holtzman. Science 2009
10
Gene expression and protein distribution of the orexin-1 receptor in the rat brain and spinal cord.
G J Hervieu, J E Cluderay, D C Harrison, J C Roberts, R A Leslie. Neuroscience 2001
G J Hervieu, J E Cluderay, D C Harrison, J C Roberts, R A Leslie. Neuroscience 2001
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Arousal and reward: a dichotomy in orexin function.
Glenda C Harris, Gary Aston-Jones. Trends Neurosci 2006
Glenda C Harris, Gary Aston-Jones. Trends Neurosci 2006
9
Hypothalamic orexin neurons regulate arousal according to energy balance in mice.
Akihiro Yamanaka, Carsten T Beuckmann, Jon T Willie, Junko Hara, Natsuko Tsujino, Michihiro Mieda, Makoto Tominaga, Ken ichi Yagami, Fumihiro Sugiyama, Katsutoshi Goto,[...]. Neuron 2003
Akihiro Yamanaka, Carsten T Beuckmann, Jon T Willie, Junko Hara, Natsuko Tsujino, Michihiro Mieda, Makoto Tominaga, Ken ichi Yagami, Fumihiro Sugiyama, Katsutoshi Goto,[...]. Neuron 2003
9
Evolution of Orexin Neuropeptide System: Structure and Function.
Shingo Soya, Takeshi Sakurai. Front Neurosci 2020
Shingo Soya, Takeshi Sakurai. Front Neurosci 2020
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Role of orexin-1 receptor mechanisms on compulsive food consumption in a model of binge eating in female rats.
Laura Piccoli, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani, Vivian J A Costantini, Mario Massagrande, Dino Montanari, Prisca Martinelli, Marinella Antolini, Roberto Ciccocioppo, Maurizio Massi,[...]. Neuropsychopharmacology 2012
Laura Piccoli, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani, Vivian J A Costantini, Mario Massagrande, Dino Montanari, Prisca Martinelli, Marinella Antolini, Roberto Ciccocioppo, Maurizio Massi,[...]. Neuropsychopharmacology 2012
10
Promotion of sleep by targeting the orexin system in rats, dogs and humans.
Catherine Brisbare-Roch, Jasper Dingemanse, Ralf Koberstein, Petra Hoever, Hamed Aissaoui, Susan Flores, Celia Mueller, Oliver Nayler, Joop van Gerven, Sanne L de Haas,[...]. Nat Med 2007
Catherine Brisbare-Roch, Jasper Dingemanse, Ralf Koberstein, Petra Hoever, Hamed Aissaoui, Susan Flores, Celia Mueller, Oliver Nayler, Joop van Gerven, Sanne L de Haas,[...]. Nat Med 2007
9
Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment.
Claudio L A Bassetti, Antoine Adamantidis, Denis Burdakov, Fang Han, Steffen Gay, Ulf Kallweit, Ramin Khatami, Frits Koning, Brigitte R Kornum, Gert Jan Lammers,[...]. Nat Rev Neurol 2019
Claudio L A Bassetti, Antoine Adamantidis, Denis Burdakov, Fang Han, Steffen Gay, Ulf Kallweit, Ramin Khatami, Frits Koning, Brigitte R Kornum, Gert Jan Lammers,[...]. Nat Rev Neurol 2019
9
Hypothalamic regulation of sleep and circadian rhythms.
Clifford B Saper, Thomas E Scammell, Jun Lu. Nature 2005
Clifford B Saper, Thomas E Scammell, Jun Lu. Nature 2005
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The neurobiological basis of narcolepsy.
Carrie E Mahoney, Andrew Cogswell, Igor J Koralnik, Thomas E Scammell. Nat Rev Neurosci 2019
Carrie E Mahoney, Andrew Cogswell, Igor J Koralnik, Thomas E Scammell. Nat Rev Neurosci 2019
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Orexin A/hypocretin-1 selectively promotes motivation for positive reinforcers.
Stephanie L Borgland, Shao-Ju Chang, M Scott Bowers, Jennifer L Thompson, Nicole Vittoz, Stan B Floresco, Jonathan Chou, Billy T Chen, Antonello Bonci. J Neurosci 2009
Stephanie L Borgland, Shao-Ju Chang, M Scott Bowers, Jennifer L Thompson, Nicole Vittoz, Stan B Floresco, Jonathan Chou, Billy T Chen, Antonello Bonci. J Neurosci 2009
9
A Decade of Orexin/Hypocretin and Addiction: Where Are We Now?
Morgan H James, Stephen V Mahler, David E Moorman, Gary Aston-Jones. Curr Top Behav Neurosci 2017
Morgan H James, Stephen V Mahler, David E Moorman, Gary Aston-Jones. Curr Top Behav Neurosci 2017
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Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice.
Takeshi Sakurai, Ruby Nagata, Akihiro Yamanaka, Hiroko Kawamura, Natsuko Tsujino, Yo Muraki, Haruaki Kageyama, Satoshi Kunita, Satoru Takahashi, Katsutoshi Goto,[...]. Neuron 2005
Takeshi Sakurai, Ruby Nagata, Akihiro Yamanaka, Hiroko Kawamura, Natsuko Tsujino, Yo Muraki, Haruaki Kageyama, Satoshi Kunita, Satoru Takahashi, Katsutoshi Goto,[...]. Neuron 2005
8
The hypocretin (orexin) system: from a neural circuitry perspective.
Shi-Bin Li, Luis de Lecea. Neuropharmacology 2020
Shi-Bin Li, Luis de Lecea. Neuropharmacology 2020
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Hypocretin (orexin) facilitates reward by attenuating the antireward effects of its cotransmitter dynorphin in ventral tegmental area.
John W Muschamp, Jonathan A Hollander, Jennifer L Thompson, George Voren, Linda C Hassinger, Sara Onvani, Theodore M Kamenecka, Stephanie L Borgland, Paul J Kenny, William A Carlezon. Proc Natl Acad Sci U S A 2014
John W Muschamp, Jonathan A Hollander, Jennifer L Thompson, George Voren, Linda C Hassinger, Sara Onvani, Theodore M Kamenecka, Stephanie L Borgland, Paul J Kenny, William A Carlezon. Proc Natl Acad Sci U S A 2014
8
The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders.
T S Kilduff, C Peyron. Trends Neurosci 2000
T S Kilduff, C Peyron. Trends Neurosci 2000
8
Hypocretin (orexin) loss in Parkinson's disease.
Rolf Fronczek, Sebastiaan Overeem, Sandy Y Y Lee, Ingrid M Hegeman, Johannes van Pelt, Sjoerd G van Duinen, Gert Jan Lammers, Dick F Swaab. Brain 2007
Rolf Fronczek, Sebastiaan Overeem, Sandy Y Y Lee, Ingrid M Hegeman, Johannes van Pelt, Sjoerd G van Duinen, Gert Jan Lammers, Dick F Swaab. Brain 2007
8
Orexin/hypocretin-1 receptor antagonism reduces ethanol self-administration and reinstatement selectively in highly-motivated rats.
David E Moorman, Morgan H James, Elisabeth A Kilroy, Gary Aston-Jones. Brain Res 2017
David E Moorman, Morgan H James, Elisabeth A Kilroy, Gary Aston-Jones. Brain Res 2017
14
The hypocretin-orexin system regulates cocaine self-administration via actions on the mesolimbic dopamine system.
Rodrigo A España, Erik B Oleson, Jason L Locke, Bethany R Brookshire, David C S Roberts, Sara R Jones. Eur J Neurosci 2010
Rodrigo A España, Erik B Oleson, Jason L Locke, Bethany R Brookshire, David C S Roberts, Sara R Jones. Eur J Neurosci 2010
7
Increased Number and Activity of a Lateral Subpopulation of Hypothalamic Orexin/Hypocretin Neurons Underlies the Expression of an Addicted State in Rats.
Morgan H James, Colin M Stopper, Benjamin A Zimmer, Nikki E Koll, Hannah E Bowrey, Gary Aston-Jones. Biol Psychiatry 2019
Morgan H James, Colin M Stopper, Benjamin A Zimmer, Nikki E Koll, Hannah E Bowrey, Gary Aston-Jones. Biol Psychiatry 2019
10
Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy.
Thomas C Thannickal, Joshi John, Ling Shan, Dick F Swaab, Ming-Fung Wu, Lalini Ramanathan, Ronald McGregor, Keng-Tee Chew, Marcia Cornford, Akihiro Yamanaka,[...]. Sci Transl Med 2018
Thomas C Thannickal, Joshi John, Ling Shan, Dick F Swaab, Ming-Fung Wu, Lalini Ramanathan, Ronald McGregor, Keng-Tee Chew, Marcia Cornford, Akihiro Yamanaka,[...]. Sci Transl Med 2018
15
Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ.
Denis Burdakov, Oleg Gerasimenko, Alexei Verkhratsky. J Neurosci 2005
Denis Burdakov, Oleg Gerasimenko, Alexei Verkhratsky. J Neurosci 2005
7
The physiological role of orexin/hypocretin neurons in the regulation of sleep/wakefulness and neuroendocrine functions.
Ayumu Inutsuka, Akihiro Yamanaka. Front Endocrinol (Lausanne) 2013
Ayumu Inutsuka, Akihiro Yamanaka. Front Endocrinol (Lausanne) 2013
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Orexins Mediate Sex Differences in the Stress Response and in Cognitive Flexibility.
Laura A Grafe, Amanda Cornfeld, Sandra Luz, Rita Valentino, Seema Bhatnagar. Biol Psychiatry 2017
Laura A Grafe, Amanda Cornfeld, Sandra Luz, Rita Valentino, Seema Bhatnagar. Biol Psychiatry 2017
12
Sexually dimorphic expression of prepro-orexin mRNA in the rat hypothalamus.
Olaf Jöhren, Steffi J Neidert, Marco Kummer, Peter Dominiak. Peptides 2002
Olaf Jöhren, Steffi J Neidert, Marco Kummer, Peter Dominiak. Peptides 2002
10
Single-cell transcriptomic analysis of the lateral hypothalamic area reveals molecularly distinct populations of inhibitory and excitatory neurons.
Laura E Mickelsen, Mohan Bolisetty, Brock R Chimileski, Akie Fujita, Eric J Beltrami, James T Costanzo, Jacob R Naparstek, Paul Robson, Alexander C Jackson. Nat Neurosci 2019
Laura E Mickelsen, Mohan Bolisetty, Brock R Chimileski, Akie Fujita, Eric J Beltrami, James T Costanzo, Jacob R Naparstek, Paul Robson, Alexander C Jackson. Nat Neurosci 2019
7
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.