D A Sinclair, L Guarente. Cell 1997
Times Cited: 1060
Times Cited: 1060
Times Cited
Times Co-cited
Similarity
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.
M Kaeberlein, M McVey, L Guarente. Genes Dev 1999
M Kaeberlein, M McVey, L Guarente. Genes Dev 1999
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The hallmarks of aging.
Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer. Cell 2013
Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer. Cell 2013
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Elimination of replication block protein Fob1 extends the life span of yeast mother cells.
P A Defossez, R Prusty, M Kaeberlein, S J Lin, P Ferrigno, P A Silver, R L Keil, L Guarente. Mol Cell 1999
P A Defossez, R Prusty, M Kaeberlein, S J Lin, P Ferrigno, P A Silver, R L Keil, L Guarente. Mol Cell 1999
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Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity.
Kristen M Turner, Viraj Deshpande, Doruk Beyter, Tomoyuki Koga, Jessica Rusert, Catherine Lee, Bin Li, Karen Arden, Bing Ren, David A Nathanson,[...]. Nature 2017
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Circular DNA elements of chromosomal origin are common in healthy human somatic tissue.
Henrik Devitt Møller, Marghoob Mohiyuddin, Iñigo Prada-Luengo, M Reza Sailani, Jens Frey Halling, Peter Plomgaard, Lasse Maretty, Anders Johannes Hansen, Michael P Snyder, Henriette Pilegaard,[...]. Nat Commun 2018
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Role of SAGA in the asymmetric segregation of DNA circles during yeast ageing.
Annina Denoth-Lippuner, Marek Konrad Krzyzanowski, Catherine Stober, Yves Barral. Elife 2014
Annina Denoth-Lippuner, Marek Konrad Krzyzanowski, Catherine Stober, Yves Barral. Elife 2014
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Replicative and chronological aging in Saccharomyces cerevisiae.
Valter D Longo, Gerald S Shadel, Matt Kaeberlein, Brian Kennedy. Cell Metab 2012
Valter D Longo, Gerald S Shadel, Matt Kaeberlein, Brian Kennedy. Cell Metab 2012
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Extrachromosomal circular DNA is common in yeast.
Henrik D Møller, Lance Parsons, Tue S Jørgensen, David Botstein, Birgitte Regenberg. Proc Natl Acad Sci U S A 2015
Henrik D Møller, Lance Parsons, Tue S Jørgensen, David Botstein, Birgitte Regenberg. Proc Natl Acad Sci U S A 2015
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Excessive rDNA Transcription Drives the Disruption in Nuclear Homeostasis during Entry into Senescence in Budding Yeast.
Sandrine Morlot, Jia Song, Isabelle Léger-Silvestre, Audrey Matifas, Olivier Gadal, Gilles Charvin. Cell Rep 2019
Sandrine Morlot, Jia Song, Isabelle Léger-Silvestre, Audrey Matifas, Olivier Gadal, Gilles Charvin. Cell Rep 2019
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Circular ecDNA promotes accessible chromatin and high oncogene expression.
Sihan Wu, Kristen M Turner, Nam Nguyen, Ramya Raviram, Marcella Erb, Jennifer Santini, Jens Luebeck, Utkrisht Rajkumar, Yarui Diao, Bin Li,[...]. Nature 2019
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Ribosomal DNA and cellular senescence: new evidence supporting the connection between rDNA and aging.
Austen R D Ganley, Takehiko Kobayashi. FEMS Yeast Res 2014
Austen R D Ganley, Takehiko Kobayashi. FEMS Yeast Res 2014
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Abundance of ribosomal RNA gene copies maintains genome integrity.
Satoru Ide, Takaaki Miyazaki, Hisaji Maki, Takehiko Kobayashi. Science 2010
Satoru Ide, Takaaki Miyazaki, Hisaji Maki, Takehiko Kobayashi. Science 2010
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Extrachromosomal microDNAs and chromosomal microdeletions in normal tissues.
Yoshiyuki Shibata, Pankaj Kumar, Ryan Layer, Smaranda Willcox, Jeffrey R Gagan, Jack D Griffith, Anindya Dutta. Science 2012
Yoshiyuki Shibata, Pankaj Kumar, Ryan Layer, Smaranda Willcox, Jeffrey R Gagan, Jack D Griffith, Anindya Dutta. Science 2012
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Transcription-induced formation of extrachromosomal DNA during yeast ageing.
Ryan M Hull, Michelle King, Grazia Pizza, Felix Krueger, Xabier Vergara, Jonathan Houseley. PLoS Biol 2019
Ryan M Hull, Michelle King, Grazia Pizza, Felix Krueger, Xabier Vergara, Jonathan Houseley. PLoS Biol 2019
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Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA.
David A Nathanson, Beatrice Gini, Jack Mottahedeh, Koppany Visnyei, Tomoyuki Koga, German Gomez, Ascia Eskin, Kiwook Hwang, Jun Wang, Kenta Masui,[...]. Science 2014
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Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma.
Richard P Koche, Elias Rodriguez-Fos, Konstantin Helmsauer, Martin Burkert, Ian C MacArthur, Jesper Maag, Rocio Chamorro, Natalia Munoz-Perez, Montserrat Puiggròs, Heathcliff Dorado Garcia,[...]. Nat Genet 2020
Richard P Koche, Elias Rodriguez-Fos, Konstantin Helmsauer, Martin Burkert, Ian C MacArthur, Jesper Maag, Rocio Chamorro, Natalia Munoz-Perez, Montserrat Puiggròs, Heathcliff Dorado Garcia,[...]. Nat Genet 2020
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MOLECULAR SIZE AND CIRCULARITY OF DNA IN CELLS OF MAMMALS AND HIGHER PLANTS.
Y HOTTA, A BASSEL. Proc Natl Acad Sci U S A 1965
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An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast.
Adam L Hughes, Daniel E Gottschling. Nature 2012
Adam L Hughes, Daniel E Gottschling. Nature 2012
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Sir2-independent life span extension by calorie restriction in yeast.
Matt Kaeberlein, Kathryn T Kirkland, Stanley Fields, Brian K Kennedy. PLoS Biol 2004
Matt Kaeberlein, Kathryn T Kirkland, Stanley Fields, Brian K Kennedy. PLoS Biol 2004
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Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.
S J Lin, P A Defossez, L Guarente. Science 2000
S J Lin, P A Defossez, L Guarente. Science 2000
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A mechanism for asymmetric segregation of age during yeast budding.
Zhanna Shcheprova, Sandro Baldi, Stephanie Buvelot Frei, Gaston Gonnet, Yves Barral. Nature 2008
Zhanna Shcheprova, Sandro Baldi, Stephanie Buvelot Frei, Gaston Gonnet, Yves Barral. Nature 2008
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Production of Extrachromosomal MicroDNAs Is Linked to Mismatch Repair Pathways and Transcriptional Activity.
Laura W Dillon, Pankaj Kumar, Yoshiyuki Shibata, Yuh-Hwa Wang, Smaranda Willcox, Jack D Griffith, Yves Pommier, Shunichi Takeda, Anindya Dutta. Cell Rep 2015
Laura W Dillon, Pankaj Kumar, Yoshiyuki Shibata, Yuh-Hwa Wang, Smaranda Willcox, Jack D Griffith, Yves Pommier, Shunichi Takeda, Anindya Dutta. Cell Rep 2015
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Normal and Cancerous Tissues Release Extrachromosomal Circular DNA (eccDNA) into the Circulation.
Pankaj Kumar, Laura W Dillon, Yoshiyuki Shibata, Amir A Jazaeri, David R Jones, Anindya Dutta. Mol Cancer Res 2017
Pankaj Kumar, Laura W Dillon, Yoshiyuki Shibata, Amir A Jazaeri, David R Jones, Anindya Dutta. Mol Cancer Res 2017
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Genomic Copy-Number Loss Is Rescued by Self-Limiting Production of DNA Circles.
Andrés Mansisidor, Temistocles Molinar, Priyanka Srivastava, Demetri D Dartis, Adriana Pino Delgado, Hannah G Blitzblau, Hannah Klein, Andreas Hochwagen. Mol Cell 2018
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Histone H4 lysine 16 acetylation regulates cellular lifespan.
Weiwei Dang, Kristan K Steffen, Rocco Perry, Jean A Dorsey, F Brad Johnson, Ali Shilatifard, Matt Kaeberlein, Brian K Kennedy, Shelley L Berger. Nature 2009
Weiwei Dang, Kristan K Steffen, Rocco Perry, Jean A Dorsey, F Brad Johnson, Ali Shilatifard, Matt Kaeberlein, Brian K Kennedy, Shelley L Berger. Nature 2009
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Protein biogenesis machinery is a driver of replicative aging in yeast.
Georges E Janssens, Anne C Meinema, Javier González, Justina C Wolters, Alexander Schmidt, Victor Guryev, Rainer Bischoff, Ernst C Wit, Liesbeth M Veenhoff, Matthias Heinemann. Elife 2015
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Cellular senescence in yeast is regulated by rDNA noncoding transcription.
Kimiko Saka, Satoru Ide, Austen R D Ganley, Takehiko Kobayashi. Curr Biol 2013
Kimiko Saka, Satoru Ide, Austen R D Ganley, Takehiko Kobayashi. Curr Biol 2013
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Extrachromosomal circular DNA of tandemly repeated genomic sequences in Drosophila.
Sarit Cohen, Keren Yacobi, Daniel Segal. Genome Res 2003
Sarit Cohen, Keren Yacobi, Daniel Segal. Genome Res 2003
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The effect of replication initiation on gene amplification in the rDNA and its relationship to aging.
Austen R D Ganley, Satoru Ide, Kimiko Saka, Takehiko Kobayashi. Mol Cell 2009
Austen R D Ganley, Satoru Ide, Kimiko Saka, Takehiko Kobayashi. Mol Cell 2009
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Recombination regulation by transcription-induced cohesin dissociation in rDNA repeats.
Takehiko Kobayashi, Austen R D Ganley. Science 2005
Takehiko Kobayashi, Austen R D Ganley. Science 2005
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Expansion and contraction of ribosomal DNA repeats in Saccharomyces cerevisiae: requirement of replication fork blocking (Fob1) protein and the role of RNA polymerase I.
T Kobayashi, D J Heck, M Nomura, T Horiuchi. Genes Dev 1998
T Kobayashi, D J Heck, M Nomura, T Horiuchi. Genes Dev 1998
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Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants.
D A Sinclair, K Mills, L Guarente. Science 1997
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A new role of the rDNA and nucleolus in the nucleus--rDNA instability maintains genome integrity.
Takehiko Kobayashi. Bioessays 2008
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Discoveries of Extrachromosomal Circles of DNA in Normal and Tumor Cells.
Teressa Paulsen, Pankaj Kumar, M Murat Koseoglu, Anindya Dutta. Trends Genet 2018
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Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.
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MINUTE CHROMATIN BODIES IN MALIGNANT TUMOURS OF CHILDHOOD.
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Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma.
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Functional Enhancers Shape Extrachromosomal Oncogene Amplifications.
Andrew R Morton, Nergiz Dogan-Artun, Zachary J Faber, Graham MacLeod, Cynthia F Bartels, Megan S Piazza, Kevin C Allan, Stephen C Mack, Xiuxing Wang, Ryan C Gimple,[...]. Cell 2019
Andrew R Morton, Nergiz Dogan-Artun, Zachary J Faber, Graham MacLeod, Cynthia F Bartels, Megan S Piazza, Kevin C Allan, Stephen C Mack, Xiuxing Wang, Ryan C Gimple,[...]. Cell 2019
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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase.
S Imai, C M Armstrong, M Kaeberlein, L Guarente. Nature 2000
S Imai, C M Armstrong, M Kaeberlein, L Guarente. Nature 2000
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A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging.
Mark A McCormick, Joe R Delaney, Mitsuhiro Tsuchiya, Scott Tsuchiyama, Anna Shemorry, Sylvia Sim, Annie Chia-Zong Chou, Umema Ahmed, Daniel Carr, Christopher J Murakami,[...]. Cell Metab 2015
Mark A McCormick, Joe R Delaney, Mitsuhiro Tsuchiya, Scott Tsuchiyama, Anna Shemorry, Sylvia Sim, Annie Chia-Zong Chou, Umema Ahmed, Daniel Carr, Christopher J Murakami,[...]. Cell Metab 2015
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Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiae.
T Smeal, J Claus, B Kennedy, F Cole, L Guarente. Cell 1996
T Smeal, J Claus, B Kennedy, F Cole, L Guarente. Cell 1996
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Elevated histone expression promotes life span extension.
Jason Feser, David Truong, Chandrima Das, Joshua J Carson, Jeffrey Kieft, Troy Harkness, Jessica K Tyler. Mol Cell 2010
Jason Feser, David Truong, Chandrima Das, Joshua J Carson, Jeffrey Kieft, Troy Harkness, Jessica K Tyler. Mol Cell 2010
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Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients.
Matt Kaeberlein, R Wilson Powers, Kristan K Steffen, Eric A Westman, Di Hu, Nick Dang, Emily O Kerr, Kathryn T Kirkland, Stanley Fields, Brian K Kennedy. Science 2005
Matt Kaeberlein, R Wilson Powers, Kristan K Steffen, Eric A Westman, Di Hu, Nick Dang, Emily O Kerr, Kathryn T Kirkland, Stanley Fields, Brian K Kennedy. Science 2005
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SIR2 regulates recombination between different rDNA repeats, but not recombination within individual rRNA genes in yeast.
Takehiko Kobayashi, Takashi Horiuchi, Prasad Tongaonkar, Loan Vu, Masayasu Nomura. Cell 2004
Takehiko Kobayashi, Takashi Horiuchi, Prasad Tongaonkar, Loan Vu, Masayasu Nomura. Cell 2004
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Adaptation to diverse nitrogen-limited environments by deletion or extrachromosomal element formation of the GAP1 locus.
David Gresham, Renata Usaite, Susanne Manuela Germann, Michael Lisby, David Botstein, Birgitte Regenberg. Proc Natl Acad Sci U S A 2010
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Extrachromosomal oncogene amplification in tumour pathogenesis and evolution.
Roel G W Verhaak, Vineet Bafna, Paul S Mischel. Nat Rev Cancer 2019
Roel G W Verhaak, Vineet Bafna, Paul S Mischel. Nat Rev Cancer 2019
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Gene amplification as double minutes or homogeneously staining regions in solid tumors: origin and structure.
Clelia Tiziana Storlazzi, Angelo Lonoce, Maria C Guastadisegni, Domenico Trombetta, Pietro D'Addabbo, Giulia Daniele, Alberto L'Abbate, Gemma Macchia, Cecilia Surace, Klaas Kok,[...]. Genome Res 2010
Clelia Tiziana Storlazzi, Angelo Lonoce, Maria C Guastadisegni, Domenico Trombetta, Pietro D'Addabbo, Giulia Daniele, Alberto L'Abbate, Gemma Macchia, Cecilia Surace, Klaas Kok,[...]. Genome Res 2010
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Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers.
Hoon Kim, Nam-Phuong Nguyen, Kristen Turner, Sihan Wu, Amit D Gujar, Jens Luebeck, Jihe Liu, Viraj Deshpande, Utkrisht Rajkumar, Sandeep Namburi,[...]. Nat Genet 2020
Hoon Kim, Nam-Phuong Nguyen, Kristen Turner, Sihan Wu, Amit D Gujar, Jens Luebeck, Jihe Liu, Viraj Deshpande, Utkrisht Rajkumar, Sandeep Namburi,[...]. Nat Genet 2020
13
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.