B van Steensel, A Smogorzewska, T de Lange. Cell 1998
Times Cited: 1339
Times Cited: 1339
Times Cited
Times Co-cited
Similarity
Shelterin: the protein complex that shapes and safeguards human telomeres.
Titia de Lange. Genes Dev 2005
Titia de Lange. Genes Dev 2005
39
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.
Eros Lazzerini Denchi, Titia de Lange. Nature 2007
Eros Lazzerini Denchi, Titia de Lange. Nature 2007
36
Mammalian telomeres end in a large duplex loop.
J D Griffith, L Comeau, S Rosenfield, R M Stansel, A Bianchi, H Moss, T de Lange. Cell 1999
J D Griffith, L Comeau, S Rosenfield, R M Stansel, A Bianchi, H Moss, T de Lange. Cell 1999
30
p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2.
J Karlseder, D Broccoli, Y Dai, S Hardy, T de Lange. Science 1999
J Karlseder, D Broccoli, Y Dai, S Hardy, T de Lange. Science 1999
25
DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion.
Giulia B Celli, Titia de Lange. Nat Cell Biol 2005
Giulia B Celli, Titia de Lange. Nat Cell Biol 2005
24
Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation.
Ylli Doksani, John Y Wu, Titia de Lange, Xiaowei Zhuang. Cell 2013
Ylli Doksani, John Y Wu, Titia de Lange, Xiaowei Zhuang. Cell 2013
22
DNA damage foci at dysfunctional telomeres.
Hiroyuki Takai, Agata Smogorzewska, Titia de Lange. Curr Biol 2003
Hiroyuki Takai, Agata Smogorzewska, Titia de Lange. Curr Biol 2003
22
21
A two-step mechanism for TRF2-mediated chromosome-end protection.
Keiji Okamoto, Cristina Bartocci, Iliana Ouzounov, Jolene K Diedrich, John R Yates, Eros Lazzerini Denchi. Nature 2013
Keiji Okamoto, Cristina Bartocci, Iliana Ouzounov, Jolene K Diedrich, John R Yates, Eros Lazzerini Denchi. Nature 2013
20
Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication.
Agnel Sfeir, Settapong T Kosiyatrakul, Dirk Hockemeyer, Sheila L MacRae, Jan Karlseder, Carl L Schildkraut, Titia de Lange. Cell 2009
Agnel Sfeir, Settapong T Kosiyatrakul, Dirk Hockemeyer, Sheila L MacRae, Jan Karlseder, Carl L Schildkraut, Titia de Lange. Cell 2009
18
Control of telomere length by the human telomeric protein TRF1.
B van Steensel, T de Lange. Nature 1997
B van Steensel, T de Lange. Nature 1997
18
Identification of human Rap1: implications for telomere evolution.
B Li, S Oestreich, T de Lange. Cell 2000
B Li, S Oestreich, T de Lange. Cell 2000
17
A DNA damage checkpoint response in telomere-initiated senescence.
Fabrizio d'Adda di Fagagna, Philip M Reaper, Lorena Clay-Farrace, Heike Fiegler, Philippa Carr, Thomas Von Zglinicki, Gabriele Saretzki, Nigel P Carter, Stephen P Jackson. Nature 2003
Fabrizio d'Adda di Fagagna, Philip M Reaper, Lorena Clay-Farrace, Heike Fiegler, Philippa Carr, Thomas Von Zglinicki, Gabriele Saretzki, Nigel P Carter, Stephen P Jackson. Nature 2003
17
Control of human telomere length by TRF1 and TRF2.
A Smogorzewska, B van Steensel, A Bianchi, S Oelmann, M R Schaefer, G Schnapp, T de Lange. Mol Cell Biol 2000
A Smogorzewska, B van Steensel, A Bianchi, S Oelmann, M R Schaefer, G Schnapp, T de Lange. Mol Cell Biol 2000
17
Telomeres shorten during ageing of human fibroblasts.
C B Harley, A B Futcher, C W Greider. Nature 1990
C B Harley, A B Futcher, C W Greider. Nature 1990
16
Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2.
D Broccoli, A Smogorzewska, L Chong, T de Lange. Nat Genet 1997
D Broccoli, A Smogorzewska, L Chong, T de Lange. Nat Genet 1997
16
TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions.
Rekha Rai, Yong Chen, Ming Lei, Sandy Chang. Nat Commun 2016
Rekha Rai, Yong Chen, Ming Lei, Sandy Chang. Nat Commun 2016
20
Telomeres in cancer: tumour suppression and genome instability.
John Maciejowski, Titia de Lange. Nat Rev Mol Cell Biol 2017
John Maciejowski, Titia de Lange. Nat Rev Mol Cell Biol 2017
15
Removal of shelterin reveals the telomere end-protection problem.
Agnel Sfeir, Titia de Lange. Science 2012
Agnel Sfeir, Titia de Lange. Science 2012
15
Telomeric localization of TRF2, a novel human telobox protein.
T Bilaud, C Brun, K Ancelin, C E Koering, T Laroche, E Gilson. Nat Genet 1997
T Bilaud, C Brun, K Ancelin, C E Koering, T Laroche, E Gilson. Nat Genet 1997
14
Pot1, the putative telomere end-binding protein in fission yeast and humans.
P Baumann, T R Cech. Science 2001
P Baumann, T R Cech. Science 2001
14
DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2.
Agata Smogorzewska, Jan Karlseder, Heidi Holtgreve-Grez, Anna Jauch, Titia de Lange. Curr Biol 2002
Agata Smogorzewska, Jan Karlseder, Heidi Holtgreve-Grez, Anna Jauch, Titia de Lange. Curr Biol 2002
13
Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination.
Giulia B Celli, Eros Lazzerini Denchi, Titia de Lange. Nat Cell Biol 2006
Giulia B Celli, Eros Lazzerini Denchi, Titia de Lange. Nat Cell Biol 2006
12
Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres.
Ling Wu, Asha S Multani, Hua He, Wilfredo Cosme-Blanco, Yu Deng, Jian Min Deng, Olga Bachilo, Sen Pathak, Hedioshi Tahara, Susan M Bailey,[...]. Cell 2006
Ling Wu, Asha S Multani, Hua He, Wilfredo Cosme-Blanco, Yu Deng, Jian Min Deng, Olga Bachilo, Sen Pathak, Hedioshi Tahara, Susan M Bailey,[...]. Cell 2006
12
Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal.
Agnel Sfeir, Shaheen Kabir, Megan van Overbeek, Giulia B Celli, Titia de Lange. Science 2010
Agnel Sfeir, Shaheen Kabir, Megan van Overbeek, Giulia B Celli, Titia de Lange. Science 2010
12
TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.
Jeffrey Zheng-Sheng Ye, Jill R Donigian, Megan van Overbeek, Diego Loayza, Yan Luo, Andrew N Krutchinsky, Brian T Chait, Titia de Lange. J Biol Chem 2004
Jeffrey Zheng-Sheng Ye, Jill R Donigian, Megan van Overbeek, Diego Loayza, Yan Luo, Andrew N Krutchinsky, Brian T Chait, Titia de Lange. J Biol Chem 2004
12
TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage.
Jing Ye, Christelle Lenain, Serge Bauwens, Angela Rizzo, Adelaïde Saint-Léger, Anaïs Poulet, Delphine Benarroch, Frédérique Magdinier, Julia Morere, Simon Amiard,[...]. Cell 2010
Jing Ye, Christelle Lenain, Serge Bauwens, Angela Rizzo, Adelaïde Saint-Léger, Anaïs Poulet, Delphine Benarroch, Frédérique Magdinier, Julia Morere, Simon Amiard,[...]. Cell 2010
12
Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST.
Peng Wu, Hiroyuki Takai, Titia de Lange. Cell 2012
Peng Wu, Hiroyuki Takai, Titia de Lange. Cell 2012
12
Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends.
Claus M Azzalin, Patrick Reichenbach, Lela Khoriauli, Elena Giulotto, Joachim Lingner. Science 2007
Claus M Azzalin, Patrick Reichenbach, Lela Khoriauli, Elena Giulotto, Joachim Lingner. Science 2007
11
Specific association of human telomerase activity with immortal cells and cancer.
N W Kim, M A Piatyszek, K R Prowse, C B Harley, M D West, P L Ho, G M Coviello, W E Wright, S L Weinrich, J W Shay. Science 1994
N W Kim, M A Piatyszek, K R Prowse, C B Harley, M D West, P L Ho, G M Coviello, W E Wright, S L Weinrich, J W Shay. Science 1994
11
PTOP interacts with POT1 and regulates its localization to telomeres.
Dan Liu, Amin Safari, Matthew S O'Connor, Doug W Chan, Andrew Laegeler, Jun Qin, Zhou Songyang. Nat Cell Biol 2004
Dan Liu, Amin Safari, Matthew S O'Connor, Doug W Chan, Andrew Laegeler, Jun Qin, Zhou Songyang. Nat Cell Biol 2004
11
TIN2, a new regulator of telomere length in human cells.
S H Kim, P Kaminker, J Campisi. Nat Genet 1999
S H Kim, P Kaminker, J Campisi. Nat Genet 1999
11
POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex.
Jeffrey Zheng-Sheng Ye, Dirk Hockemeyer, Andrew N Krutchinsky, Diego Loayza, Sarah M Hooper, Brian T Chait, Titia de Lange. Genes Dev 2004
Jeffrey Zheng-Sheng Ye, Dirk Hockemeyer, Andrew N Krutchinsky, Diego Loayza, Sarah M Hooper, Brian T Chait, Titia de Lange. Genes Dev 2004
11
The POT1-TPP1 telomere complex is a telomerase processivity factor.
Feng Wang, Elaine R Podell, Arthur J Zaug, Yuting Yang, Paul Baciu, Thomas R Cech, Ming Lei. Nature 2007
Feng Wang, Elaine R Podell, Arthur J Zaug, Yuting Yang, Paul Baciu, Thomas R Cech, Ming Lei. Nature 2007
11
The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response.
Jan Karlseder, Kristina Hoke, Olga K Mirzoeva, Christopher Bakkenist, Michael B Kastan, John H J Petrini, Titia de Lange. PLoS Biol 2004
Jan Karlseder, Kristina Hoke, Olga K Mirzoeva, Christopher Bakkenist, Michael B Kastan, John H J Petrini, Titia de Lange. PLoS Biol 2004
11
A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly.
Matthew S O'Connor, Amin Safari, Huawei Xin, Dan Liu, Zhou Songyang. Proc Natl Acad Sci U S A 2006
Matthew S O'Connor, Amin Safari, Huawei Xin, Dan Liu, Zhou Songyang. Proc Natl Acad Sci U S A 2006
11
Chromothripsis and Kataegis Induced by Telomere Crisis.
John Maciejowski, Yilong Li, Nazario Bosco, Peter J Campbell, Titia de Lange. Cell 2015
John Maciejowski, Yilong Li, Nazario Bosco, Peter J Campbell, Titia de Lange. Cell 2015
11
A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
Yong Chen, Yuting Yang, Megan van Overbeek, Jill R Donigian, Paul Baciu, Titia de Lange, Ming Lei. Science 2008
Yong Chen, Yuting Yang, Megan van Overbeek, Jill R Donigian, Paul Baciu, Titia de Lange, Ming Lei. Science 2008
11
TERRA RNA binding to TRF2 facilitates heterochromatin formation and ORC recruitment at telomeres.
Zhong Deng, Julie Norseen, Andreas Wiedmer, Harold Riethman, Paul M Lieberman. Mol Cell 2009
Zhong Deng, Julie Norseen, Andreas Wiedmer, Harold Riethman, Paul M Lieberman. Mol Cell 2009
10
Telomere Loop Dynamics in Chromosome End Protection.
David Van Ly, Ronnie Ren Jie Low, Sonja Frölich, Tara K Bartolec, Georgia R Kafer, Hilda A Pickett, Katharina Gaus, Anthony J Cesare. Mol Cell 2018
David Van Ly, Ronnie Ren Jie Low, Sonja Frölich, Tara K Bartolec, Georgia R Kafer, Hilda A Pickett, Katharina Gaus, Anthony J Cesare. Mol Cell 2018
17
Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites.
Paula Martinez, Maria Thanasoula, Ana R Carlos, Gonzalo Gómez-López, Agueda M Tejera, Stefan Schoeftner, Orlando Dominguez, David G Pisano, Madalena Tarsounas, Maria A Blasco. Nat Cell Biol 2010
Paula Martinez, Maria Thanasoula, Ana R Carlos, Gonzalo Gómez-López, Agueda M Tejera, Stefan Schoeftner, Orlando Dominguez, David G Pisano, Madalena Tarsounas, Maria A Blasco. Nat Cell Biol 2010
10
Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression.
Hsiangling Teo, Sourav Ghosh, Hendrik Luesch, Arkasubhra Ghosh, Ee Tsin Wong, Najib Malik, Anthony Orth, Paul de Jesus, Anthony S Perry, Jeffrey D Oliver,[...]. Nat Cell Biol 2010
Hsiangling Teo, Sourav Ghosh, Hendrik Luesch, Arkasubhra Ghosh, Ee Tsin Wong, Najib Malik, Anthony Orth, Paul de Jesus, Anthony S Perry, Jeffrey D Oliver,[...]. Nat Cell Biol 2010
10
Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2.
L Fairall, L Chapman, H Moss, T de Lange, D Rhodes. Mol Cell 2001
L Fairall, L Chapman, H Moss, T de Lange, D Rhodes. Mol Cell 2001
10
Telomere protection by TPP1/POT1 requires tethering to TIN2.
Kaori K Takai, Tatsuya Kibe, Jill R Donigian, David Frescas, Titia de Lange. Mol Cell 2011
Kaori K Takai, Tatsuya Kibe, Jill R Donigian, David Frescas, Titia de Lange. Mol Cell 2011
10
Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice.
Paula Martínez, Maria Thanasoula, Purificación Muñoz, Chunyan Liao, Agueda Tejera, Carolyn McNees, Juana M Flores, Oscar Fernández-Capetillo, Madalena Tarsounas, Maria A Blasco. Genes Dev 2009
Paula Martínez, Maria Thanasoula, Purificación Muñoz, Chunyan Liao, Agueda Tejera, Carolyn McNees, Juana M Flores, Oscar Fernández-Capetillo, Madalena Tarsounas, Maria A Blasco. Genes Dev 2009
10
TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection.
Delphine Benarroch-Popivker, Sabrina Pisano, Aaron Mendez-Bermudez, Liudmyla Lototska, Parminder Kaur, Serge Bauwens, Nadir Djerbi, Chrysa M Latrick, Vincent Fraisier, Bei Pei,[...]. Mol Cell 2016
Delphine Benarroch-Popivker, Sabrina Pisano, Aaron Mendez-Bermudez, Liudmyla Lototska, Parminder Kaur, Serge Bauwens, Nadir Djerbi, Chrysa M Latrick, Vincent Fraisier, Bei Pei,[...]. Mol Cell 2016
11
Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis.
Xiaolan Guo, Yibin Deng, Yahong Lin, Wilfredo Cosme-Blanco, Suzanne Chan, Hua He, Guohua Yuan, Eric J Brown, Sandy Chang. EMBO J 2007
Xiaolan Guo, Yibin Deng, Yahong Lin, Wilfredo Cosme-Blanco, Suzanne Chan, Hua He, Guohua Yuan, Eric J Brown, Sandy Chang. EMBO J 2007
10
Homologous recombination generates T-loop-sized deletions at human telomeres.
Richard C Wang, Agata Smogorzewska, Titia de Lange. Cell 2004
Richard C Wang, Agata Smogorzewska, Titia de Lange. Cell 2004
10
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.