K L Burns, K Ueki, S L Jhung, J Koh, D N Louis. J Neuropathol Exp Neurol 1998
Times Cited: 102
Times Cited: 102
Times Cited
Times Co-cited
Similarity
CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated.
K Ueki, Y Ono, J W Henson, J T Efird, A von Deimling, D N Louis. Cancer Res 1996
K Ueki, Y Ono, J W Henson, J T Efird, A von Deimling, D N Louis. Cancer Res 1996
50
Alterations of cell cycle regulatory genes in primary (de novo) and secondary glioblastomas.
W Biernat, Y Tohma, Y Yonekawa, P Kleihues, H Ohgaki. Acta Neuropathol 1997
W Biernat, Y Tohma, Y Yonekawa, P Kleihues, H Ohgaki. Acta Neuropathol 1997
28
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.
M Serrano, G J Hannon, D Beach. Nature 1993
M Serrano, G J Hannon, D Beach. Nature 1993
23
Human glioblastomas with no alterations of the CDKN2A (p16INK4A, MTS1) and CDK4 genes have frequent mutations of the retinoblastoma gene.
K Ichimura, E E Schmidt, H M Goike, V P Collins. Oncogene 1996
K Ichimura, E E Schmidt, H M Goike, V P Collins. Oncogene 1996
21
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways.
Y Zhang, Y Xiong, W G Yarbrough. Cell 1998
Y Zhang, Y Xiong, W G Yarbrough. Cell 1998
20
Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas.
K Watanabe, O Tachibana, K Sata, Y Yonekawa, P Kleihues, H Ohgaki. Brain Pathol 1996
K Watanabe, O Tachibana, K Sata, Y Yonekawa, P Kleihues, H Ohgaki. Brain Pathol 1996
19
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53.
J Pomerantz, N Schreiber-Agus, N J Liégeois, A Silverman, L Alland, L Chin, J Potes, K Chen, I Orlow, H W Lee,[...]. Cell 1998
J Pomerantz, N Schreiber-Agus, N J Liégeois, A Silverman, L Alland, L Chin, J Potes, K Chen, I Orlow, H W Lee,[...]. Cell 1998
18
Pathways leading to glioblastoma multiforme: a molecular analysis of genetic alterations in 65 astrocytic tumors.
F F Lang, D C Miller, M Koslow, E W Newcomb. J Neurosurg 1994
F F Lang, D C Miller, M Koslow, E W Newcomb. J Neurosurg 1994
18
CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas.
E E Schmidt, K Ichimura, G Reifenberger, V P Collins. Cancer Res 1994
E E Schmidt, K Ichimura, G Reifenberger, V P Collins. Cancer Res 1994
18
A cell cycle regulator potentially involved in genesis of many tumor types.
A Kamb, N A Gruis, J Weaver-Feldhaus, Q Liu, K Harshman, S V Tavtigian, E Stockert, R S Day, B E Johnson, M H Skolnick. Science 1994
A Kamb, N A Gruis, J Weaver-Feldhaus, Q Liu, K Harshman, S V Tavtigian, E Stockert, R S Day, B E Johnson, M H Skolnick. Science 1994
17
Malignant astrocytomas with homozygous CDKN2/p16 gene deletions have higher Ki-67 proliferation indices.
Y Ono, T Tamiya, T Ichikawa, K Kunishio, K Matsumoto, T Furuta, T Ohmoto, K Ueki, D N Louis. J Neuropathol Exp Neurol 1996
Y Ono, T Tamiya, T Ichikawa, K Kunishio, K Matsumoto, T Furuta, T Ohmoto, K Ueki, D N Louis. J Neuropathol Exp Neurol 1996
19
Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.
J G Herman, J R Graff, S Myöhänen, B D Nelkin, S B Baylin. Proc Natl Acad Sci U S A 1996
J G Herman, J R Graff, S Myöhänen, B D Nelkin, S B Baylin. Proc Natl Acad Sci U S A 1996
16
PTEN (MMAC1) mutations are frequent in primary glioblastomas (de novo) but not in secondary glioblastomas.
Y Tohma, C Gratas, W Biernat, A Peraud, M Fukuda, Y Yonekawa, P Kleihues, H Ohgaki. J Neuropathol Exp Neurol 1998
Y Tohma, C Gratas, W Biernat, A Peraud, M Fukuda, Y Yonekawa, P Kleihues, H Ohgaki. J Neuropathol Exp Neurol 1998
16
Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations.
G Reifenberger, L Liu, K Ichimura, E E Schmidt, V P Collins. Cancer Res 1993
G Reifenberger, L Liu, K Ichimura, E E Schmidt, V P Collins. Cancer Res 1993
15
The retinoblastoma gene is involved in malignant progression of astrocytomas.
J W Henson, B L Schnitker, K M Correa, A von Deimling, F Fassbender, H J Xu, W F Benedict, D W Yandell, D N Louis. Ann Neurol 1994
J W Henson, B L Schnitker, K M Correa, A von Deimling, F Fassbender, H J Xu, W F Benedict, D W Yandell, D N Louis. Ann Neurol 1994
15
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest.
D E Quelle, F Zindy, R A Ashmun, C J Sherr. Cell 1995
D E Quelle, F Zindy, R A Ashmun, C J Sherr. Cell 1995
15
Association of EGFR gene amplification and CDKN2 (p16/MTS1) gene deletion in glioblastoma multiforme.
Y Hayashi, K Ueki, A Waha, O D Wiestler, D N Louis, A von Deimling. Brain Pathol 1997
Y Hayashi, K Ueki, A Waha, O D Wiestler, D N Louis, A von Deimling. Brain Pathol 1997
15
5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers.
A Merlo, J G Herman, L Mao, D J Lee, E Gabrielson, P C Burger, S B Baylin, D Sidransky. Nat Med 1995
A Merlo, J G Herman, L Mao, D J Lee, E Gabrielson, P C Burger, S B Baylin, D Sidransky. Nat Med 1995
14
Incidence and timing of p53 mutations during astrocytoma progression in patients with multiple biopsies.
K Watanabe, K Sato, W Biernat, O Tachibana, K von Ammon, N Ogata, Y Yonekawa, P Kleihues, H Ohgaki. Clin Cancer Res 1997
K Watanabe, K Sato, W Biernat, O Tachibana, K von Ammon, N Ogata, Y Yonekawa, P Kleihues, H Ohgaki. Clin Cancer Res 1997
14
Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities.
K Ichimura, M B Bolin, H M Goike, E E Schmidt, A Moshref, V P Collins. Cancer Res 2000
K Ichimura, M B Bolin, H M Goike, E E Schmidt, A Moshref, V P Collins. Cancer Res 2000
14
Survival of patients with glioblastoma multiforme is not influenced by altered expression of p16, p53, EGFR, MDM2 or Bcl-2 genes.
E W Newcomb, H Cohen, S R Lee, S K Bhalla, J Bloom, R L Hayes, D C Miller. Brain Pathol 1998
E W Newcomb, H Cohen, S R Lee, S K Bhalla, J Bloom, R L Hayes, D C Miller. Brain Pathol 1998
13
Deletion of p16 and p15 genes in brain tumors.
J Jen, J W Harper, S H Bigner, D D Bigner, N Papadopoulos, S Markowitz, J K Willson, K W Kinzler, B Vogelstein. Cancer Res 1994
J Jen, J W Harper, S H Bigner, D D Bigner, N Papadopoulos, S Markowitz, J K Willson, K W Kinzler, B Vogelstein. Cancer Res 1994
13
Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation.
J F Costello, M S Berger, H S Huang, W K Cavenee. Cancer Res 1996
J F Costello, M S Berger, H S Huang, W K Cavenee. Cancer Res 1996
13
Infrequent methylation of CDKN2A(MTS1/p16) and rare mutation of both CDKN2A and CDKN2B(MTS2/p15) in primary astrocytic tumours.
E E Schmidt, K Ichimura, K R Messerle, H M Goike, V P Collins. Br J Cancer 1997
E E Schmidt, K Ichimura, K R Messerle, H M Goike, V P Collins. Br J Cancer 1997
17
MTS1/p16/CDKN2 lesions in primary glioblastoma multiforme.
T Moulton, G Samara, W Y Chung, L Yuan, R Desai, M Sisti, J Bruce, B Tycko. Am J Pathol 1995
T Moulton, G Samara, W Y Chung, L Yuan, R Desai, M Sisti, J Bruce, B Tycko. Am J Pathol 1995
14
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers.
P A Steck, M A Pershouse, S A Jasser, W K Yung, H Lin, A H Ligon, L A Langford, M L Baumgard, T Hattier, T Davis,[...]. Nat Genet 1997
P A Steck, M A Pershouse, S A Jasser, W K Yung, H Lin, A H Ligon, L A Langford, M L Baumgard, T Hattier, T Davis,[...]. Nat Genet 1997
12
Subsets of glioblastoma multiforme defined by molecular genetic analysis.
A von Deimling, K von Ammon, D Schoenfeld, O D Wiestler, B R Seizinger, D N Louis. Brain Pathol 1993
A von Deimling, K von Ammon, D Schoenfeld, O D Wiestler, B R Seizinger, D N Louis. Brain Pathol 1993
12
Amplification and overexpression of MDM2 in primary (de novo) glioblastomas.
W Biernat, P Kleihues, Y Yonekawa, H Ohgaki. J Neuropathol Exp Neurol 1997
W Biernat, P Kleihues, Y Yonekawa, H Ohgaki. J Neuropathol Exp Neurol 1997
12
MTS1/CDKN2 gene mutations are rare in primary human astrocytomas with allelic loss of chromosome 9p.
K Ueki, M P Rubio, V Ramesh, K M Correa, J L Rutter, A von Deimling, A J Buckler, J F Gusella, D N Louis. Hum Mol Genet 1994
K Ueki, M P Rubio, V Ramesh, K M Correa, J L Rutter, A von Deimling, A J Buckler, J F Gusella, D N Louis. Hum Mol Genet 1994
11
Somatic mutations of PTEN in glioblastoma multiforme.
S I Wang, J Puc, J Li, J N Bruce, P Cairns, D Sidransky, R Parsons. Cancer Res 1997
S I Wang, J Puc, J Li, J N Bruce, P Cairns, D Sidransky, R Parsons. Cancer Res 1997
11
Lack of p16INK4 or retinoblastoma protein (pRb), or amplification-associated overexpression of cdk4 is observed in distinct subsets of malignant glial tumors and cell lines.
J He, J J Olson, C D James. Cancer Res 1995
J He, J J Olson, C D James. Cancer Res 1995
11
PTEN mutations in gliomas and glioneuronal tumors.
E M Duerr, B Rollbrocker, Y Hayashi, N Peters, B Meyer-Puttlitz, D N Louis, J Schramm, O D Wiestler, R Parsons, C Eng,[...]. Oncogene 1998
E M Duerr, B Rollbrocker, Y Hayashi, N Peters, B Meyer-Puttlitz, D N Louis, J Schramm, O D Wiestler, R Parsons, C Eng,[...]. Oncogene 1998
10
Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers.
T Nobori, K Miura, D J Wu, A Lois, K Takabayashi, D A Carson. Nature 1994
T Nobori, K Miura, D J Wu, A Lois, K Takabayashi, D A Carson. Nature 1994
10
Role of the INK4a locus in tumor suppression and cell mortality.
M Serrano, H Lee, L Chin, C Cordon-Cardo, D Beach, R A DePinho. Cell 1996
M Serrano, H Lee, L Chin, C Cordon-Cardo, D Beach, R A DePinho. Cell 1996
10
Hemizygous or homozygous deletion of the chromosomal region containing the p16INK4a gene is associated with amplification of the EGF receptor gene in glioblastomas.
M E Hegi, A zur Hausen, D Rüedi, G Malin, P Kleihues. Int J Cancer 1997
M E Hegi, A zur Hausen, D Rüedi, G Malin, P Kleihues. Int J Cancer 1997
21
CDK4 amplification is an alternative mechanism to p16 gene homozygous deletion in glioma cell lines.
J He, J R Allen, V P Collins, M J Allalunis-Turner, R Godbout, R S Day, C D James. Cancer Res 1994
J He, J R Allen, V P Collins, M J Allalunis-Turner, R Godbout, R S Day, C D James. Cancer Res 1994
10
Germline p16 mutations in familial melanoma.
C J Hussussian, J P Struewing, A M Goldstein, P A Higgins, D S Ally, M D Sheahan, W H Clark, M A Tucker, N C Dracopoli. Nat Genet 1994
C J Hussussian, J P Struewing, A M Goldstein, P A Higgins, D S Ally, M D Sheahan, W H Clark, M A Tucker, N C Dracopoli. Nat Genet 1994
9
Analysis of p53 mutation and epidermal growth factor receptor amplification in recurrent gliomas with malignant progression.
J Reifenberger, G U Ring, U Gies, L Cobbers, J Oberstrass, H X An, D Niederacher, W Wechsler, G Reifenberger. J Neuropathol Exp Neurol 1996
J Reifenberger, G U Ring, U Gies, L Cobbers, J Oberstrass, H X An, D Niederacher, W Wechsler, G Reifenberger. J Neuropathol Exp Neurol 1996
9
Loss of P16INK4 expression is frequent in high grade gliomas.
R Nishikawa, F B Furnari, H Lin, W Arap, M S Berger, W K Cavenee, H J Su Huang. Cancer Res 1995
R Nishikawa, F B Furnari, H Lin, W Arap, M S Berger, W K Cavenee, H J Su Huang. Cancer Res 1995
9
Structural alterations of the epidermal growth factor receptor gene in human gliomas.
A J Wong, J M Ruppert, S H Bigner, C H Grzeschik, P A Humphrey, D S Bigner, B Vogelstein. Proc Natl Acad Sci U S A 1992
A J Wong, J M Ruppert, S H Bigner, C H Grzeschik, P A Humphrey, D S Bigner, B Vogelstein. Proc Natl Acad Sci U S A 1992
9
Genetic alterations associated with the evolution and progression of astrocytic brain tumours.
H Ohgaki, B Schäuble, A zur Hausen, K von Ammon, P Kleihues. Virchows Arch 1995
H Ohgaki, B Schäuble, A zur Hausen, K von Ammon, P Kleihues. Virchows Arch 1995
9
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer.
J Li, C Yen, D Liaw, K Podsypanina, S Bose, S I Wang, J Puc, C Miliaresis, L Rodgers, R McCombie,[...]. Science 1997
J Li, C Yen, D Liaw, K Podsypanina, S Bose, S I Wang, J Puc, C Miliaresis, L Rodgers, R McCombie,[...]. Science 1997
9
Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition.
J Koh, G H Enders, B D Dynlacht, E Harlow. Nature 1995
J Koh, G H Enders, B D Dynlacht, E Harlow. Nature 1995
9
Hypermethylation of the CpG island of p16/CDKN2 correlates with gene inactivation in gliomas.
J Fueyo, C Gomez-Manzano, J M Bruner, Y Saito, B Zhang, W Zhang, V A Levin, W K Yung, A P Kyritsis. Oncogene 1996
J Fueyo, C Gomez-Manzano, J M Bruner, Y Saito, B Zhang, W Zhang, V A Levin, W K Yung, A P Kyritsis. Oncogene 1996
11
The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.
F J Stott, S Bates, M C James, B B McConnell, M Starborg, S Brookes, I Palmero, K Ryan, E Hara, K H Vousden,[...]. EMBO J 1998
F J Stott, S Bates, M C James, B B McConnell, M Starborg, S Brookes, I Palmero, K Ryan, E Hara, K H Vousden,[...]. EMBO J 1998
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A novel p16INK4A transcript.
L Mao, A Merlo, G Bedi, G I Shapiro, C D Edwards, B J Rollins, D Sidransky. Cancer Res 1995
L Mao, A Merlo, G Bedi, G I Shapiro, C D Edwards, B J Rollins, D Sidransky. Cancer Res 1995
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Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas.
J G Cairncross, K Ueki, M C Zlatescu, D K Lisle, D M Finkelstein, R R Hammond, J S Silver, P C Stark, D R Macdonald, Y Ino,[...]. J Natl Cancer Inst 1998
J G Cairncross, K Ueki, M C Zlatescu, D K Lisle, D M Finkelstein, R R Hammond, J S Silver, P C Stark, D R Macdonald, Y Ino,[...]. J Natl Cancer Inst 1998
8
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.