A citation-based method for searching scientific literature

M K Cooper, J A Porter, K E Young, P A Beachy. Science 1998
Times Cited: 698







List of co-cited articles
1100 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.
James K Chen, Jussi Taipale, Michael K Cooper, Philip A Beachy. Genes Dev 2002
36

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.
J Taipale, J K Chen, M K Cooper, B Wang, R K Mann, L Milenkovic, M P Scott, P A Beachy. Nature 2000
34

The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction.
J P Incardona, W Gaffield, R P Kapur, H Roelink. Development 1998
507
31

Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist.
Shifeng Pan, Xu Wu, Jiqing Jiang, Wenqi Gao, Yongqin Wan, Dai Cheng, Dong Han, Jun Liu, Nathan P Englund, Yan Wang,[...]. ACS Med Chem Lett 2010
197
27


Activating Smoothened mutations in sporadic basal-cell carcinoma.
J Xie, M Murone, S M Luoh, A Ryan, Q Gu, C Zhang, J M Bonifas, C W Lam, M Hynes, A Goddard,[...]. Nature 1998
986
24

GDC-0449-a potent inhibitor of the hedgehog pathway.
Kirk D Robarge, Shirley A Brunton, Georgette M Castanedo, Yong Cui, Michael S Dina, Richard Goldsmith, Stephen E Gould, Oivin Guichert, Janet L Gunzner, Jason Halladay,[...]. Bioorg Med Chem Lett 2009
279
24

Structure of the human smoothened receptor bound to an antitumour agent.
Chong Wang, Huixian Wu, Vsevolod Katritch, Gye Won Han, Xi-Ping Huang, Wei Liu, Fai Yiu Siu, Bryan L Roth, Vadim Cherezov, Raymond C Stevens. Nature 2013
334
23

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.
Robert L Yauch, Gerrit J P Dijkgraaf, Bruno Alicke, Thomas Januario, Christina P Ahn, Thomas Holcomb, Kanan Pujara, Jeremy Stinson, Christopher A Callahan, Tracy Tang,[...]. Science 2009
621
23

Small molecule modulation of Smoothened activity.
James K Chen, Jussi Taipale, Keith E Young, Tapan Maiti, Philip A Beachy. Proc Natl Acad Sci U S A 2002
745
20

Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists.
Matthias Lauth, Asa Bergström, Takashi Shimokawa, Rune Toftgård. Proc Natl Acad Sci U S A 2007
559
20

Efficacy and safety of vismodegib in advanced basal-cell carcinoma.
Aleksandar Sekulic, Michael R Migden, Anthony E Oro, Luc Dirix, Karl D Lewis, John D Hainsworth, James A Solomon, Simon Yoo, Sarah T Arron, Philip A Friedlander,[...]. N Engl J Med 2012
827
20

Mutations affecting segment number and polarity in Drosophila.
C Nüsslein-Volhard, E Wieschaus. Nature 1980
20

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma.
Daniel D Von Hoff, Patricia M LoRusso, Charles M Rudin, Josina C Reddy, Robert L Yauch, Raoul Tibes, Glen J Weiss, Mitesh J Borad, Christine L Hann, Julie R Brahmer,[...]. N Engl J Med 2009
804
19

Patched1 regulates hedgehog signaling at the primary cilium.
Rajat Rohatgi, Ljiljana Milenkovic, Matthew P Scott. Science 2007
954
19

Smoothened variants explain the majority of drug resistance in basal cell carcinoma.
Scott X Atwood, Kavita Y Sarin, Ramon J Whitson, Jiang R Li, Geurim Kim, Melika Rezaee, Mina S Ally, Jinah Kim, Catherine Yao, Anne Lynn S Chang,[...]. Cancer Cell 2015
241
19

The mechanisms of Hedgehog signalling and its roles in development and disease.
James Briscoe, Pascal P Thérond. Nat Rev Mol Cell Biol 2013
979
19

Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs.
Chong Wang, Huixian Wu, Tama Evron, Eyal Vardy, Gye Won Han, Xi-Ping Huang, Sandy J Hufeisen, Thomas J Mangano, Dan J Urban, Vsevolod Katritch,[...]. Nat Commun 2014
157
18


Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926).
Martin R Tremblay, André Lescarbeau, Michael J Grogan, Eddy Tan, Grace Lin, Brian C Austad, Lin-Chen Yu, Mark L Behnke, Somarajan J Nair, Margit Hagel,[...]. J Med Chem 2009
173
17

Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma.
Hayley J Sharpe, Gregoire Pau, Gerrit J Dijkgraaf, Nicole Basset-Seguin, Zora Modrusan, Thomas Januario, Vickie Tsui, Alison B Durham, Andrzej A Dlugosz, Peter M Haverty,[...]. Cancer Cell 2015
224
17

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling.
Sigrid Nachtergaele, Daniel M Whalen, Laurel K Mydock, Zhonghua Zhao, Tomas Malinauskas, Kathiresan Krishnan, Philip W Ingham, Douglas F Covey, Christian Siebold, Rajat Rohatgi. Elife 2013
107
16

Patched acts catalytically to suppress the activity of Smoothened.
J Taipale, M K Cooper, T Maiti, P A Beachy. Nature 2002
574
16

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449.
Charles M Rudin, Christine L Hann, John Laterra, Robert L Yauch, Christopher A Callahan, Ling Fu, Thomas Holcomb, Jeremy Stinson, Stephen E Gould, Barbara Coleman,[...]. N Engl J Med 2009
747
16

Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth.
James Kim, Jean Y Tang, Ruoyu Gong, Jynho Kim, John J Lee, Karl V Clemons, Curtis R Chong, Kris S Chang, Mark Fereshteh, Dale Gardner,[...]. Cancer Cell 2010
339
16

Structural basis of Smoothened regulation by its extracellular domains.
Eamon F X Byrne, Ria Sircar, Paul S Miller, George Hedger, Giovanni Luchetti, Sigrid Nachtergaele, Mark D Tully, Laurel Mydock-McGrane, Douglas F Covey, Robert P Rambo,[...]. Nature 2016
199
16

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.
C Chiang, Y Litingtung, E Lee, K E Young, J L Corden, H Westphal, P A Beachy. Nature 1996
15

Human homolog of patched, a candidate gene for the basal cell nevus syndrome.
R L Johnson, A L Rothman, J Xie, L V Goodrich, J W Bare, J M Bonifas, A G Quinn, R M Myers, D R Cox, E H Epstein,[...]. Science 1996
15

Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling.
Pengxiang Huang, Daniel Nedelcu, Miyako Watanabe, Cindy Jao, Youngchang Kim, Jing Liu, Adrian Salic. Cell 2016
192
15

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity.
Y Echelard, D J Epstein, B St-Jacques, L Shen, J Mohler, J A McMahon, A P McMahon. Cell 1993
15

Hedgehog signalling in prostate regeneration, neoplasia and metastasis.
Sunil S Karhadkar, G Steven Bova, Nadia Abdallah, Surajit Dhara, Dale Gardner, Anirban Maitra, John T Isaacs, David M Berman, Philip A Beachy. Nature 2004
797
14

Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response.
Benjamin R Myers, Navdar Sever, Yong Chun Chong, James Kim, Jitendra D Belani, Scott Rychnovsky, J Fernando Bazan, Philip A Beachy. Dev Cell 2013
123
14

Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling.
Daniel Nedelcu, Jing Liu, Yangqing Xu, Cindy Jao, Adrian Salic. Nat Chem Biol 2013
130
14

Vertebrate Smoothened functions at the primary cilium.
Kevin C Corbit, Pia Aanstad, Veena Singla, Andrew R Norman, Didier Y R Stainier, Jeremy F Reiter. Nature 2005
14

A paracrine requirement for hedgehog signalling in cancer.
Robert L Yauch, Stephen E Gould, Suzie J Scales, Tracy Tang, Hua Tian, Christina P Ahn, Derek Marshall, Ling Fu, Thomas Januario, Dara Kallop,[...]. Nature 2008
745
14


Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector.
Jynho Kim, John J Lee, James Kim, Dale Gardner, Philip A Beachy. Proc Natl Acad Sci U S A 2010
214
14

Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways.
Barbara Stecca, Christophe Mas, Virginie Clement, Marie Zbinden, Rafael Correa, Vincent Piguet, Friedrich Beermann, Ariel Ruiz i Altaba. Proc Natl Acad Sci U S A 2007
383
14

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer.
D Neil Watkins, David M Berman, Scott G Burkholder, Baolin Wang, Philip A Beachy, Stephen B Baylin. Nature 2003
830
13

A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis.
Michael K Cooper, Christopher A Wassif, Patrycja A Krakowiak, Jussi Taipale, Ruoyu Gong, Richard I Kelley, Forbes D Porter, Philip A Beachy. Nat Genet 2003
276
13

Oxysterols are allosteric activators of the oncoprotein Smoothened.
Sigrid Nachtergaele, Laurel K Mydock, Kathiresan Krishnan, Jayan Rammohan, Paul H Schlesinger, Douglas F Covey, Rajat Rohatgi. Nat Chem Biol 2012
176
13

Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.
Silvia Buonamici, Juliet Williams, Michael Morrissey, Anlai Wang, Ribo Guo, Anthony Vattay, Kathy Hsiao, Jing Yuan, John Green, Beatriz Ospina,[...]. Sci Transl Med 2010
350
13

Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance.
Gerrit J P Dijkgraaf, Bruno Alicke, Lasse Weinmann, Thomas Januario, Kristina West, Zora Modrusan, Dan Burdick, Richard Goldsmith, Kirk Robarge, Dan Sutherlin,[...]. Cancer Res 2011
257
13

Targeting the Hedgehog pathway in cancer.
Lee L Rubin, Frederic J de Sauvage. Nat Rev Drug Discov 2006
581
13

A small molecule that binds Hedgehog and blocks its signaling in human cells.
Benjamin Z Stanton, Lee F Peng, Nicole Maloof, Kazuo Nakai, Xiang Wang, Jay L Duffner, Kennedy M Taveras, Joel M Hyman, Sam W Lee, Angela N Koehler,[...]. Nat Chem Biol 2009
207
13

Hedgehog: functions and mechanisms.
Markku Varjosalo, Jussi Taipale. Genes Dev 2008
825
13

Regulation of the oncoprotein Smoothened by small molecules.
Hayley J Sharpe, Weiru Wang, Rami N Hannoush, Frederic J de Sauvage. Nat Chem Biol 2015
85
14

An Investigator-Initiated Open-Label Trial of Sonidegib in Advanced Basal Cell Carcinoma Patients Resistant to Vismodegib.
Christina Danial, Kavita Y Sarin, Anthony E Oro, Anne Lynn S Chang. Clin Cancer Res 2016
75
16

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome.
H Hahn, C Wicking, P G Zaphiropoulous, M R Gailani, S Shanley, A Chidambaram, I Vorechovsky, E Holmberg, A B Unden, S Gillies,[...]. Cell 1996
12

Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway.
Elspeth M Beauchamp, Lymor Ringer, Gülay Bulut, Kamal P Sajwan, Michael D Hall, Yi-Chien Lee, Daniel Peaceman, Metin Ozdemirli, Olga Rodriguez, Tobey J Macdonald,[...]. J Clin Invest 2011
227
12


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.