M C Naski, J S Colvin, J D Coffin, D M Ornitz. Development 1998
Times Cited: 295
Times Cited: 295
Times Cited
Times Co-cited
Similarity
Fibroblast growth factor receptor 3 is a negative regulator of bone growth.
C Deng, A Wynshaw-Boris, F Zhou, A Kuo, P Leder. Cell 1996
C Deng, A Wynshaw-Boris, F Zhou, A Kuo, P Leder. Cell 1996
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Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3.
J S Colvin, B A Bohne, G W Harding, D G McEwen, D M Ornitz. Nat Genet 1996
J S Colvin, B A Bohne, G W Harding, D G McEwen, D M Ornitz. Nat Genet 1996
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Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia.
F Rousseau, J Bonaventure, L Legeai-Mallet, A Pelet, J M Rozet, P Maroteaux, M Le Merrer, A Munnich. Nature 1994
F Rousseau, J Bonaventure, L Legeai-Mallet, A Pelet, J M Rozet, P Maroteaux, M Le Merrer, A Munnich. Nature 1994
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Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia.
R Shiang, L M Thompson, Y Z Zhu, D M Church, T J Fielder, M Bocian, S T Winokur, J J Wasmuth. Cell 1994
R Shiang, L M Thompson, Y Z Zhu, D M Church, T J Fielder, M Bocian, S T Winokur, J J Wasmuth. Cell 1994
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A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos.
T Iwata, L Chen, C Li, D A Ovchinnikov, R R Behringer, C A Francomano, C X Deng. Hum Mol Genet 2000
T Iwata, L Chen, C Li, D A Ovchinnikov, R R Behringer, C A Francomano, C X Deng. Hum Mol Genet 2000
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Evaluation of the therapeutic potential of a CNP analog in a Fgfr3 mouse model recapitulating achondroplasia.
Florence Lorget, Nabil Kaci, Jeff Peng, Catherine Benoist-Lasselin, Emilie Mugniery, Todd Oppeneer, Dan J Wendt, Sean M Bell, Sherry Bullens, Stuart Bunting,[...]. Am J Hum Genet 2012
Florence Lorget, Nabil Kaci, Jeff Peng, Catherine Benoist-Lasselin, Emilie Mugniery, Todd Oppeneer, Dan J Wendt, Sean M Bell, Sherry Bullens, Stuart Bunting,[...]. Am J Hum Genet 2012
32
Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype.
Shunichi Murakami, Gener Balmes, Sandra McKinney, Zhaoping Zhang, David Givol, Benoit de Crombrugghe. Genes Dev 2004
Shunichi Murakami, Gener Balmes, Sandra McKinney, Zhaoping Zhang, David Givol, Benoit de Crombrugghe. Genes Dev 2004
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Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway.
Akihiro Yasoda, Yasato Komatsu, Hideki Chusho, Takashi Miyazawa, Ami Ozasa, Masako Miura, Tatsuya Kurihara, Tomohiro Rogi, Shoji Tanaka, Michio Suda,[...]. Nat Med 2004
Akihiro Yasoda, Yasato Komatsu, Hideki Chusho, Takashi Miyazawa, Ami Ozasa, Masako Miura, Tatsuya Kurihara, Tomohiro Rogi, Shoji Tanaka, Michio Suda,[...]. Nat Med 2004
29
Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis.
L Chen, R Adar, X Yang, E O Monsonego, C Li, P V Hauschka, A Yayon, C X Deng. J Clin Invest 1999
L Chen, R Adar, X Yang, E O Monsonego, C Li, P V Hauschka, A Yayon, C X Deng. J Clin Invest 1999
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A Ser(365)-->Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasia.
L Chen, C Li, W Qiao, X Xu, C Deng. Hum Mol Genet 2001
L Chen, C Li, W Qiao, X Xu, C Deng. Hum Mol Genet 2001
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Interaction of FGF, Ihh/Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation.
Eleonora Minina, Conny Kreschel, Michael C Naski, David M Ornitz, Andrea Vortkamp. Dev Cell 2002
Eleonora Minina, Conny Kreschel, Michael C Naski, David M Ornitz, Andrea Vortkamp. Dev Cell 2002
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A mouse model for achondroplasia produced by targeting fibroblast growth factor receptor 3.
Y Wang, M K Spatz, K Kannan, H Hayk, A Avivi, M Gorivodsky, M Pines, A Yayon, P Lonai, D Givol. Proc Natl Acad Sci U S A 1999
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Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18.
Zhonghao Liu, Jingsong Xu, Jennifer S Colvin, David M Ornitz. Genes Dev 2002
Zhonghao Liu, Jingsong Xu, Jennifer S Colvin, David M Ornitz. Genes Dev 2002
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Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation.
B St-Jacques, M Hammerschmidt, A P McMahon. Genes Dev 1999
B St-Jacques, M Hammerschmidt, A P McMahon. Genes Dev 1999
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FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway.
M Sahni, D C Ambrosetti, A Mansukhani, R Gertner, D Levy, C Basilico. Genes Dev 1999
M Sahni, D C Ambrosetti, A Mansukhani, R Gertner, D Levy, C Basilico. Genes Dev 1999
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FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease.
David M Ornitz, Pierre J Marie. Genes Dev 2002
David M Ornitz, Pierre J Marie. Genes Dev 2002
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A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors.
C Li, L Chen, T Iwata, M Kitagawa, X Y Fu, C X Deng. Hum Mol Genet 1999
C Li, L Chen, T Iwata, M Kitagawa, X Y Fu, C X Deng. Hum Mol Genet 1999
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FGF signaling in the developing endochondral skeleton.
David M Ornitz. Cytokine Growth Factor Rev 2005
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Systemic administration of C-type natriuretic peptide as a novel therapeutic strategy for skeletal dysplasias.
Akihiro Yasoda, Hidetomo Kitamura, Toshihito Fujii, Eri Kondo, Naoaki Murao, Masako Miura, Naotetsu Kanamoto, Yasato Komatsu, Hiroshi Arai, Kazuwa Nakao. Endocrinology 2009
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26
FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway.
Takehiko Matsushita, William R Wilcox, Yuk Yu Chan, Aya Kawanami, Hülya Bükülmez, Gener Balmes, Pavel Krejci, Pertchoui B Mekikian, Kazuyuki Otani, Isakichi Yamaura,[...]. Hum Mol Genet 2009
Takehiko Matsushita, William R Wilcox, Yuk Yu Chan, Aya Kawanami, Hülya Bükülmez, Gener Balmes, Pavel Krejci, Pertchoui B Mekikian, Kazuyuki Otani, Isakichi Yamaura,[...]. Hum Mol Genet 2009
27
FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis.
Norihiko Ohbayashi, Masaki Shibayama, Yoko Kurotaki, Mayumi Imanishi, Toshihiko Fujimori, Nobuyuki Itoh, Shinji Takada. Genes Dev 2002
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Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia.
M C Naski, Q Wang, J Xu, D M Ornitz. Nat Genet 1996
M C Naski, Q Wang, J Xu, D M Ornitz. Nat Genet 1996
20
FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate.
Zhonghao Liu, Kory J Lavine, Irene H Hung, David M Ornitz. Dev Biol 2007
Zhonghao Liu, Kory J Lavine, Irene H Hung, David M Ornitz. Dev Biol 2007
20
Postnatal soluble FGFR3 therapy rescues achondroplasia symptoms and restores bone growth in mice.
Stéphanie Garcia, Béatrice Dirat, Thomas Tognacci, Nathalie Rochet, Xavier Mouska, Stéphanie Bonnafous, Stéphanie Patouraux, Albert Tran, Philippe Gual, Yannick Le Marchand-Brustel,[...]. Sci Transl Med 2013
Stéphanie Garcia, Béatrice Dirat, Thomas Tognacci, Nathalie Rochet, Xavier Mouska, Stéphanie Bonnafous, Stéphanie Patouraux, Albert Tran, Philippe Gual, Yannick Le Marchand-Brustel,[...]. Sci Transl Med 2013
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Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein.
A Vortkamp, K Lee, B Lanske, G V Segre, H M Kronenberg, C J Tabin. Science 1996
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Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3.
P L Tavormina, R Shiang, L M Thompson, Y Z Zhu, D J Wilkin, R S Lachman, W R Wilcox, D L Rimoin, D H Cohn, J J Wasmuth. Nat Genet 1995
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Fibroblast growth factor receptor 1 signaling in the osteo-chondrogenic cell lineage regulates sequential steps of osteoblast maturation.
Anne L Jacob, Craig Smith, Juha Partanen, David M Ornitz. Dev Biol 2006
Anne L Jacob, Craig Smith, Juha Partanen, David M Ornitz. Dev Biol 2006
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Unique expression pattern of the FGF receptor 3 gene during mouse organogenesis.
K Peters, D Ornitz, S Werner, L Williams. Dev Biol 1993
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Dwarfism and early death in mice lacking C-type natriuretic peptide.
H Chusho, N Tamura, Y Ogawa, A Yasoda, M Suda, T Miyazawa, K Nakamura, K Nakao, T Kurihara, Y Komatsu,[...]. Proc Natl Acad Sci U S A 2001
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18
Gain-of-function mutation in FGFR3 in mice leads to decreased bone mass by affecting both osteoblastogenesis and osteoclastogenesis.
Nan Su, Qidi Sun, Can Li, Xiumin Lu, Huabing Qi, Siyu Chen, Jing Yang, Xiaolan Du, Ling Zhao, Qifen He,[...]. Hum Mol Genet 2010
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28
Statin treatment rescues FGFR3 skeletal dysplasia phenotypes.
Akihiro Yamashita, Miho Morioka, Hiromi Kishi, Takeshi Kimura, Yasuhito Yahara, Minoru Okada, Kaori Fujita, Hideaki Sawai, Shiro Ikegawa, Noriyuki Tsumaki. Nature 2014
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18
Interaction of fibroblast growth factor and C-natriuretic peptide signaling in regulation of chondrocyte proliferation and extracellular matrix homeostasis.
Pavel Krejci, Bernard Masri, Vincent Fontaine, Pertchoui B Mekikian, Maryann Weis, Herve Prats, William R Wilcox. J Cell Sci 2005
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A recurrent mutation in the tyrosine kinase domain of fibroblast growth factor receptor 3 causes hypochondroplasia.
G A Bellus, I McIntosh, E A Smith, A S Aylsworth, I Kaitila, W A Horton, G A Greenhaw, J T Hecht, C A Francomano. Nat Genet 1995
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Achondroplasia is defined by recurrent G380R mutations of FGFR3.
G A Bellus, T W Hefferon, R I Ortiz de Luna, J T Hecht, W A Horton, M Machado, I Kaitila, I McIntosh, C A Francomano. Am J Hum Genet 1995
G A Bellus, T W Hefferon, R I Ortiz de Luna, J T Hecht, W A Horton, M Machado, I Kaitila, I McIntosh, C A Francomano. Am J Hum Genet 1995
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Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism.
W C Su, M Kitagawa, N Xue, B Xie, S Garofalo, J Cho, C Deng, W A Horton, X Y Fu. Nature 1997
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Cellular signaling by fibroblast growth factor receptors.
V P Eswarakumar, I Lax, J Schlessinger. Cytokine Growth Factor Rev 2005
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Fibroblast growth factor signaling in skeletal development and disease.
David M Ornitz, Pierre J Marie. Genes Dev 2015
David M Ornitz, Pierre J Marie. Genes Dev 2015
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Highly activated Fgfr3 with the K644M mutation causes prolonged survival in severe dwarf mice.
T Iwata, C L Li, C X Deng, C A Francomano. Hum Mol Genet 2001
T Iwata, C L Li, C X Deng, C A Francomano. Hum Mol Genet 2001
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Activating Fgfr3 Y367C mutation causes hearing loss and inner ear defect in a mouse model of chondrodysplasia.
Stéphanie Pannier, Vincent Couloigner, Nadia Messaddeq, Monique Elmaleh-Bergès, Arnold Munnich, Raymond Romand, Laurence Legeai-Mallet. Biochim Biophys Acta 2009
Stéphanie Pannier, Vincent Couloigner, Nadia Messaddeq, Monique Elmaleh-Bergès, Arnold Munnich, Raymond Romand, Laurence Legeai-Mallet. Biochim Biophys Acta 2009
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FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod.
Irene H Hung, Kai Yu, Kory J Lavine, David M Ornitz. Dev Biol 2007
Irene H Hung, Kai Yu, Kory J Lavine, David M Ornitz. Dev Biol 2007
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Restrained chondrocyte proliferation and maturation with abnormal growth plate vascularization and ossification in human FGFR-3(G380R) transgenic mice.
O Segev, I Chumakov, Z Nevo, D Givol, L Madar-Shapiro, Y Sheinin, M Weinreb, A Yayon. Hum Mol Genet 2000
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Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth.
Kai Yu, Jingsong Xu, Zhonghao Liu, Drazen Sosic, Jiansu Shao, Eric N Olson, Dwight A Towler, David M Ornitz. Development 2003
Kai Yu, Jingsong Xu, Zhonghao Liu, Drazen Sosic, Jiansu Shao, Eric N Olson, Dwight A Towler, David M Ornitz. Development 2003
14
Overexpression of FGFR3, Stat1, Stat5 and p21Cip1 correlates with phenotypic severity and defective chondrocyte differentiation in FGFR3-related chondrodysplasias.
L Legeai-Mallet, C Benoist-Lasselin, A Munnich, J Bonaventure. Bone 2004
L Legeai-Mallet, C Benoist-Lasselin, A Munnich, J Bonaventure. Bone 2004
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A network of transcriptional and signaling events is activated by FGF to induce chondrocyte growth arrest and differentiation.
Lisa Dailey, Emmanuel Laplantine, Riccardo Priore, Claudio Basilico. J Cell Biol 2003
Lisa Dailey, Emmanuel Laplantine, Riccardo Priore, Claudio Basilico. J Cell Biol 2003
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A novel mutation in FGFR3 causes camptodactyly, tall stature, and hearing loss (CATSHL) syndrome.
Reha M Toydemir, Anna E Brassington, Pinar Bayrak-Toydemir, Patrycja A Krakowiak, Lynn B Jorde, Frank G Whitby, Nicola Longo, David H Viskochil, John C Carey, Michael J Bamshad. Am J Hum Genet 2006
Reha M Toydemir, Anna E Brassington, Pinar Bayrak-Toydemir, Patrycja A Krakowiak, Lynn B Jorde, Frank G Whitby, Nicola Longo, David H Viskochil, John C Carey, Michael J Bamshad. Am J Hum Genet 2006
15
Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog.
Carolina A Yoshida, Hiromitsu Yamamoto, Takashi Fujita, Tatsuya Furuichi, Kosei Ito, Ken-ichi Inoue, Kei Yamana, Akira Zanma, Kenji Takada, Yoshiaki Ito,[...]. Genes Dev 2004
Carolina A Yoshida, Hiromitsu Yamamoto, Takashi Fujita, Tatsuya Furuichi, Kosei Ito, Ken-ichi Inoue, Kei Yamana, Akira Zanma, Kenji Takada, Yoshiaki Ito,[...]. Genes Dev 2004
13
Snail1 is a transcriptional effector of FGFR3 signaling during chondrogenesis and achondroplasias.
Cristina A de Frutos, Sonia Vega, Miguel Manzanares, Juana M Flores, Hector Huertas, M Luisa Martínez-Frías, M Angela Nieto. Dev Cell 2007
Cristina A de Frutos, Sonia Vega, Miguel Manzanares, Juana M Flores, Hector Huertas, M Luisa Martínez-Frías, M Angela Nieto. Dev Cell 2007
20
PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth.
B Lanske, A C Karaplis, K Lee, A Luz, A Vortkamp, A Pirro, M Karperien, L H Defize, C Ho, R C Mulligan,[...]. Science 1996
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13
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.