A citation-based method for searching scientific literature

Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice.
Owen M Peters, Gabriela Toro Cabrera, Helene Tran, Tania F Gendron, Jeanne E McKeon, Jake Metterville, Alexandra Weiss, Nicholas Wightman, Johnny Salameh, Juyhun Kim, Huaming Sun, Kevin B Boylan, Dennis Dickson, Zack Kennedy, Ziqiang Lin, Yong-Jie Zhang, Lillian Daughrity, Chris Jung, Fen-Biao Gao, Peter C Sapp, H Robert Horvitz, Daryl A Bosco, Solange P Brown, Pieter de Jong, Leonard Petrucelli, Chris Mueller, Robert H Brown. Neuron 2015
Times Cited: 177



Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease.
Aaron Burberry, Naoki Suzuki, Jin-Yuan Wang, Rob Moccia, Daniel A Mordes, Morag H Stewart, Satomi Suzuki-Uematsu, Sulagna Ghosh, Ajay Singh, Florian T Merkle, Kathryn Koszka, Quan-Zhen Li, Leonard Zon, Derrick J Rossi, Jennifer J Trowbridge, Luigi D Notarangelo, Kevin Eggan. Sci Transl Med 2016
Times Cited: 154




List of shared articles



Times cited

Suppression of mutant C9orf72 expression by a potent mixed backbone antisense oligonucleotide.
Hélène Tran, Michael P Moazami, Huiya Yang, Diane McKenna-Yasek, Catherine L Douthwright, Courtney Pinto, Jake Metterville, Minwook Shin, Nitasha Sanil, Craig Dooley,[...]. Nat Med 2022
6

Modelling amyotrophic lateral sclerosis in rodents.
Tiffany W Todd, Leonard Petrucelli. Nat Rev Neurosci 2022
1

Dual-gRNA approach with limited off-target effect corrects C9ORF72 repeat expansion in vivo.
Xuejiao Piao, Dawei Meng, Xue Zhang, Qiang Song, Hailong Lv, Yichang Jia. Sci Rep 2022
0

Antisense Oligonucleotides for the Study and Treatment of ALS.
Benjamin D Boros, Kathleen M Schoch, Collin J Kreple, Timothy M Miller. Neurotherapeutics 2022
0

Ablation of C9orf72 together with excitotoxicity induces ALS in rats.
Wei Dong, Yuanwu Ma, Feifei Guan, Xu Zhang, Wei Chen, Li Zhang, Lianfeng Zhang. FEBS J 2021
6

Repeat length increases disease penetrance and severity in C9orf72 ALS/FTD BAC transgenic mice.
Amrutha Pattamatta, Lien Nguyen, Hailey R Olafson, Marina M Scotti, Lauren A Laboissonniere, Jared Richardson, J Andrew Berglund, Tao Zu, Eric T Wang, Laura P W Ranum. Hum Mol Genet 2021
4

Glial Cell Dysfunction in C9orf72-Related Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.
Mehdi Ghasemi, Kiandokht Keyhanian, Catherine Douthwright. Cells 2021
7

C9orf72 ALS-FTD: recent evidence for dysregulation of the autophagy-lysosome pathway at multiple levels.
Jimmy Beckers, Arun Kumar Tharkeshwar, Philip Van Damme. Autophagy 2021
9

BET bromodomain inhibitors PFI-1 and JQ1 are identified in an epigenetic compound screen to enhance C9ORF72 gene expression and shown to ameliorate C9ORF72-associated pathological and behavioral abnormalities in a C9ALS/FTD model.
Esteban Quezada, Claudio Cappelli, Iván Diaz, Nur Jury, Nicholas Wightman, Robert H Brown, Martín Montecino, Brigitte van Zundert. Clin Epigenetics 2021
1

Non-neuronal cells in amyotrophic lateral sclerosis - from pathogenesis to biomarkers.
Björn F Vahsen, Elizabeth Gray, Alexander G Thompson, Olaf Ansorge, Daniel C Anthony, Sally A Cowley, Kevin Talbot, Martin R Turner. Nat Rev Neurol 2021
27

C9ORF72: What It Is, What It Does, and Why It Matters.
Julie Smeyers, Elena-Gaia Banchi, Morwena Latouche. Front Cell Neurosci 2021
11

Interplay between immunity and amyotrophic lateral sclerosis: Clinical impact.
Fabiola De Marchi, Ivana Munitic, Amedeo Amedei, James D Berry, Eva L Feldman, Eleonora Aronica, Giovanni Nardo, Donatienne Van Weehaeghe, Elena Niccolai, Nikolina Prtenjaca,[...]. Neurosci Biobehav Rev 2021
1

Modeling C9orf72-Related Frontotemporal Dementia and Amyotrophic Lateral Sclerosis in Drosophila.
Joanne L Sharpe, Nikki S Harper, Duncan R Garner, Ryan J H West. Front Cell Neurosci 2021
0

Nearly 30 Years of Animal Models to Study Amyotrophic Lateral Sclerosis: A Historical Overview and Future Perspectives.
Tiziana Bonifacino, Roberta Arianna Zerbo, Matilde Balbi, Carola Torazza, Giulia Frumento, Ernesto Fedele, Giambattista Bonanno, Marco Milanese. Int J Mol Sci 2021
6

Dysfunction of RNA/RNA-Binding Proteins in ALS Astrocytes and Microglia.
Simona Rossi, Mauro Cozzolino. Cells 2021
1

Modeling cell-autonomous motor neuron phenotypes in ALS using iPSCs.
James Hawrot, Sophie Imhof, Brian J Wainger. Neurobiol Dis 2020
25

Reduced autophagy upon C9ORF72 loss synergizes with dipeptide repeat protein toxicity in G4C2 repeat expansion disorders.
Manon Boivin, Véronique Pfister, Angeline Gaucherot, Frank Ruffenach, Luc Negroni, Chantal Sellier, Nicolas Charlet-Berguerand. EMBO J 2020
50

Glial Cells-The Strategic Targets in Amyotrophic Lateral Sclerosis Treatment.
Tereza Filipi, Zuzana Hermanova, Jana Tureckova, Ondrej Vanatko, And Miroslava Anderova. J Clin Med 2020
28

Omics Approach to Axonal Dysfunction of Motor Neurons in Amyotrophic Lateral Sclerosis (ALS).
Naoki Suzuki, Tetsuya Akiyama, Hitoshi Warita, Masashi Aoki. Front Neurosci 2020
16

Metabolomics: A Tool to Understand the Impact of Genetic Mutations in Amyotrophic Lateral Sclerosis.
Débora Lanznaster, Charlotte Veyrat-Durebex, Patrick Vourc'h, Christian R Andres, Hélène Blasco, Philippe Corcia. Genes (Basel) 2020
7

Divergence, Convergence, and Therapeutic Implications: A Cell Biology Perspective of C9ORF72-ALS/FTD.
Xiaoqiang Tang, Arturo Toro, Sahana T G, Junli Gao, Jessica Chalk, Björn Oskarsson, Ke Zhang. Mol Neurodegener 2020
10

Role of the C9ORF72 Gene in the Pathogenesis of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.
Zongbing Hao, Rui Wang, Haigang Ren, Guanghui Wang. Neurosci Bull 2020
2

Neuronal Transcriptome from C9orf72 Repeat Expanded Human Tissue is Associated with Loss of C9orf72 Function.
Elaine Y Liu, Jenny Russ, Edward B Lee. Free Neuropathol 2020
1

Insights into disease mechanisms and potential therapeutics for C9orf72-related amyotrophic lateral sclerosis/frontotemporal dementia.
Delia Gagliardi, Gianluca Costamagna, Michela Taiana, Luca Andreoli, Fabio Biella, Margherita Bersani, Nereo Bresolin, Giacomo Pietro Comi, Stefania Corti. Ageing Res Rev 2020
2

The Development of C9orf72-Related Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Disorders.
Qijie Yang, Bin Jiao, Lu Shen. Front Genet 2020
7

Preclinical models of disease and multimorbidity with focus upon cardiovascular disease and dementia.
Osman Shabir, Tobias A Moll, Martyna M Matuszyk, Beth Eyre, Manmohi D Dake, Jason Berwick, Sheila E Francis. Mech Ageing Dev 2020
3

Absence of Survival and Motor Deficits in 500 Repeat C9ORF72 BAC Mice.
Daniel A Mordes, Brett M Morrison, Xanthe H Ament, Christopher Cantrell, Joanie Mok, Pierce Eggan, Carolyn Xue, Jin-Yuan Wang, Kevin Eggan, Jeffrey D Rothstein. Neuron 2020
15

RNA Binding Proteins and the Pathogenesis of Frontotemporal Lobar Degeneration.
Jeffrey W Hofmann, William W Seeley, Eric J Huang. Annu Rev Pathol 2019
17

Review: Modelling the pathology and behaviour of frontotemporal dementia.
D A Solomon, J C Mitchell, M-T Salcher-Konrad, C A Vance, S Mizielinska. Neuropathol Appl Neurobiol 2019
9

C9orf72 deficiency promotes motor deficits of a C9ALS/FTD mouse model in a dose-dependent manner.
Qiang Shao, Chen Liang, Qing Chang, Wei Zhang, Mei Yang, Jian-Fu Chen. Acta Neuropathol Commun 2019
30

Motor dysfunction and neurodegeneration in a C9orf72 mouse line expressing poly-PR.
Zongbing Hao, Liu Liu, Zhouteng Tao, Rui Wang, Haigang Ren, Hongyang Sun, Zixuan Lin, Zhixiong Zhang, Chenchen Mu, Jiawei Zhou,[...]. Nat Commun 2019
32

Pathogenic Mechanisms and Therapy Development for C9orf72 Amyotrophic Lateral Sclerosis/Frontotemporal Dementia.
Jie Jiang, John Ravits. Neurotherapeutics 2019
21

ALS Genetics, Mechanisms, and Therapeutics: Where Are We Now?
Rita Mejzini, Loren L Flynn, Ianthe L Pitout, Sue Fletcher, Steve D Wilton, P Anthony Akkari. Front Neurosci 2019
215

C9orf72 plays a central role in Rab GTPase-dependent regulation of autophagy.
Christopher P Webster, Emma F Smith, Andrew J Grierson, Kurt J De Vos. Small GTPases 2018
35

Sense-encoded poly-GR dipeptide repeat proteins correlate to neurodegeneration and uniquely co-localize with TDP-43 in dendrites of repeat-expanded C9orf72 amyotrophic lateral sclerosis.
Shahram Saberi, Jennifer E Stauffer, Jie Jiang, Sandra Diaz Garcia, Amy E Taylor, Derek Schulte, Takuya Ohkubo, Cheyenne L Schloffman, Marcus Maldonado, Michael Baughn,[...]. Acta Neuropathol 2018
102

Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD.
Thomas G Moens, Sarah Mizielinska, Teresa Niccoli, Jamie S Mitchell, Annora Thoeng, Charlotte E Ridler, Sebastian Grönke, Jacqueline Esser, Amanda Heslegrave, Henrik Zetterberg,[...]. Acta Neuropathol 2018
40

Mouse models of ALS: Past, present and future.
Cathleen Lutz. Brain Res 2018
52

Insights into C9ORF72-Related ALS/FTD from Drosophila and iPSC Models.
Yeliz Yuva-Aydemir, Sandra Almeida, Fen-Biao Gao. Trends Neurosci 2018
32


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