A citation-based method for searching scientific literature

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist.
F Gasparini, K Lingenhöhl, N Stoehr, P J Flor, M Heinrich, I Vranesic, M Biollaz, H Allgeier, R Heckendorn, S Urwyler, M A Varney, E C Johnson, S D Hess, S P Rao, A I Sacaan, E M Santori, G Veliçelebi, R Kuhn. Neuropharmacology 1999
Times Cited: 646



Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator.
Huixian Wu, Chong Wang, Karen J Gregory, Gye Won Han, Hyekyung P Cho, Yan Xia, Colleen M Niswender, Vsevolod Katritch, Jens Meiler, Vadim Cherezov, P Jeffrey Conn, Raymond C Stevens. Science 2014
Times Cited: 363




List of shared articles



Times cited

Allosteric Molecular Switches in Metabotropic Glutamate Receptors.
Zoltán Orgován, György G Ferenczy, György M Keserű. ChemMedChem 2021
2

International Union of Basic and Clinical Pharmacology. CXI. Pharmacology, Signaling, and Physiology of Metabotropic Glutamate Receptors.
Karen J Gregory, Cyril Goudet. Pharmacol Rev 2021
8

Structure-based discovery and development of metabotropic glutamate receptor 5 negative allosteric modulators.
Kirstie A Bennett, John A Christopher, Benjamin G Tehan. Adv Pharmacol 2020
2

Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu5) X-ray Structures.
John A Christopher, Zoltán Orgován, Miles Congreve, Andrew S Doré, James C Errey, Fiona H Marshall, Jonathan S Mason, Krzysztof Okrasa, Prakash Rucktooa, Maria J Serrano-Vega,[...]. J Med Chem 2019
45

Imaging metabotropic glutamate receptor system: Application of positron emission tomography technology in drug development.
Youwen Xu, Zizhong Li. Med Res Rev 2019
6

Profiling of orthosteric and allosteric group-III metabotropic glutamate receptor ligands on various G protein-coupled receptors with Tag-lite® assays.
Abderazak Belhocine, Pietro Veglianese, Candide Hounsou, Elodie Dupuis, Francine Acher, Thierry Durroux, Cyril Goudet, Jean-Philippe Pin. Neuropharmacology 2018
2

Biased agonism and allosteric modulation of metabotropic glutamate receptor 5.
Phuc N H Trinh, Lauren T May, Katie Leach, Karen J Gregory. Clin Sci (Lond) 2018
12

Metabotropic glutamate receptors as therapeutic targets in Parkinson's disease: An update from the last 5 years of research.
Nadhir Litim, Marc Morissette, Thérèse Di Paolo. Neuropharmacology 2017
54

Molecular insights into allosteric modulation of Class C G protein-coupled receptors.
Katie Leach, Karen J Gregory. Pharmacol Res 2017
36

Positional isomers of bispyridine benzene derivatives induce efficacy changes on mGlu5 negative allosteric modulation.
Xavier Gómez-Santacana, James A R Dalton, Xavier Rovira, Jean Philippe Pin, Cyril Goudet, Pau Gorostiza, Jesús Giraldo, Amadeu Llebaria. Eur J Med Chem 2017
8

Control of neuronal excitability by Group I metabotropic glutamate receptors.
Ana Maria Bernal Correa, Jennifer Diniz Soares Guimarães, Everton Dos Santos E Alhadas, Christopher Kushmerick. Biophys Rev 2017
7

Potential for the Rational Design of Allosteric Modulators of Class C GPCRs.
John A Christopher, Andrew S Doré, Benjamin G Tehan. Curr Top Med Chem 2017
1

Metabotropic glutamate receptor subtype 5: molecular pharmacology, allosteric modulation and stimulus bias.
K Sengmany, K J Gregory. Br J Pharmacol 2016
32

Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors.
Xavier Rovira, Fanny Malhaire, Pauline Scholler, Jordi Rodrigo, Patricia Gonzalez-Bulnes, Amadeu Llebaria, Jean-Philippe Pin, Jesús Giraldo, Cyril Goudet. FASEB J 2015
42

Structures of mGluRs shed light on the challenges of drug development of allosteric modulators.
Kirstie A Bennett, Andrew S Doré, John A Christopher, Dahlia R Weiss, Fiona H Marshall. Curr Opin Pharmacol 2015
25

GPCR crystal structures: Medicinal chemistry in the pocket.
Jeremy Shonberg, Ralf C Kling, Peter Gmeiner, Stefan Löber. Bioorg Med Chem 2015
83

Molecular Insights into Metabotropic Glutamate Receptor Allosteric Modulation.
Karen J Gregory, P Jeffrey Conn. Mol Pharmacol 2015
30


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