A citation-based method for searching scientific literature

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation.
S W Davies, M Turmaine, B A Cozens, M DiFiglia, A H Sharp, C A Ross, E Scherzinger, E E Wanker, L Mangiarini, G P Bates. Cell 1997
Times Cited: 1750



Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.
M DiFiglia, E Sapp, K O Chase, S W Davies, G P Bates, J P Vonsattel, N Aronin. Science 1997
Times Cited: 2102




List of shared articles



Times cited

[Disease-modifying treatment approaches in Huntington disease : Past and future].
Wiebke Frank, Katrin S Lindenberg, Alzbeta Mühlbäck, Jan Lewerenz, G Bernhard Landwehrmeyer. Nervenarzt 2022
0

Observation of Oligomeric States Indicates a High Structural Flexibility Required for the Onset of Polyglutamine Fibrillization.
Ho-Wah Siu, Karin Hauser. J Phys Chem Lett 2022
0

Ameliorative Role of Nutraceuticals on Neurodegenerative Diseases Using the Drosophila melanogaster as a Discovery Model to Define Bioefficacy.
Ranjana Himalian, Sandeep Kumar Singh, Mahendra Pratap Singh. J Am Nutr Assoc 2022
2

Hypothalamic expression of huntingtin causes distinct metabolic changes in Huntington's disease mice.
Elna Dickson, Rana Soylu-Kucharz, Åsa Petersén, Maria Björkqvist. Mol Metab 2022
1

Autophagy system as a potential therapeutic target for neurodegenerative diseases.
Mengying Cui, Tamotsu Yoshimori, Shuhei Nakamura. Neurochem Int 2022
2

Spatial sequestration of misfolded proteins in neurodegenerative diseases.
Sarah Rolli, Emily Mitchell Sontag. Biochem Soc Trans 2022
1

The distribution and density of Huntingtin inclusions across the Huntington disease neocortex: regional correlations with Huntingtin repeat expansion independent of pathologic grade.
Richard A Hickman, Phyllis L Faust, Karen Marder, Ai Yamamoto, Jean-Paul Vonsattel. Acta Neuropathol Commun 2022
1

Polyglutamine Expansion in Huntingtin and Mechanism of DNA Damage Repair Defects in Huntington's Disease.
Subrata Pradhan, Rui Gao, Keegan Bush, Nan Zhang, Yogesh P Wairkar, Partha S Sarkar. Front Cell Neurosci 2022
0

The Common Cellular Events in the Neurodegenerative Diseases and the Associated Role of Endoplasmic Reticulum Stress.
Soojeong Kim, Doo Kyung Kim, Seho Jeong, Jaemin Lee. Int J Mol Sci 2022
0

Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington's disease.
Ya Zhou, Thomas R Peskett, Christian Landles, John B Warner, Kirupa Sathasivam, Edward J Smith, Shu Chen, Ronald Wetzel, Hilal A Lashuel, Gillian P Bates,[...]. Acta Neuropathol Commun 2021
1

Small, Seeding-Competent Huntingtin Fibrils Are Prominent Aggregate Species in Brains of zQ175 Huntington's Disease Knock-in Mice.
Franziska Schindler, Nicole Praedel, Nancy Neuendorf, Severine Kunz, Sigrid Schnoegl, Michael A Mason, Bridget A Taxy, Gillian P Bates, Ali Khoshnan, Josef Priller,[...]. Front Neurosci 2021
2

An Expanded Polyproline Domain Maintains Mutant Huntingtin Soluble in vivo and During Aging.
Maria Lucia Pigazzini, Mandy Lawrenz, Anca Margineanu, Gabriele S Kaminski Schierle, Janine Kirstein. Front Mol Neurosci 2021
1

A possible non-proteolytic role of ubiquitin conjugation in alleviating the pathology of Huntingtin's aggregation.
Noam E Ziv, Aaron Ciechanover. Cell Death Differ 2021
2

Tunneling nanotubes: A novel pharmacological target for neurodegenerative diseases?
Xiao-Tong Wang, Hua Sun, Nai-Hong Chen, Yu-He Yuan. Pharmacol Res 2021
3

Altered microRNA expression in animal models of Huntington's disease and potential therapeutic strategies.
Bridget Martinez, Philip V Peplow. Neural Regen Res 2021
6

Kinetic analysis reveals that independent nucleation events determine the progression of polyglutamine aggregation in C. elegans.
Tessa Sinnige, Georg Meisl, Thomas C T Michaels, Michele Vendruscolo, Tuomas P J Knowles, Richard I Morimoto. Proc Natl Acad Sci U S A 2021
2

Mitochondrial membranes modify mutant huntingtin aggregation.
Adewale Adegbuyiro, Faezeh Sedighi, Pranav Jain, Mark V Pinti, Chathuranga Siriwardhana, John M Hollander, Justin Legleiter. Biochim Biophys Acta Biomembr 2021
3

New Avenues for the Treatment of Huntington's Disease.
Amy Kim, Kathryn Lalonde, Aaron Truesdell, Priscilla Gomes Welter, Patricia S Brocardo, Tatiana R Rosenstock, Joana Gil-Mohapel. Int J Mol Sci 2021
8

The Nt17 Domain and its Helical Conformation Regulate the Aggregation, Cellular Properties and Neurotoxicity of Mutant Huntingtin Exon 1.
Sophie Vieweg, Anne-Laure Mahul-Mellier, Francesco S Ruggeri, Nathan Riguet, Sean M DeGuire, Anass Chiki, Urszula Cendrowska, Giovanni Dietler, Hilal A Lashuel. J Mol Biol 2021
4

Mislocalization of Nucleocytoplasmic Transport Proteins in Human Huntington's Disease PSC-Derived Striatal Neurons.
Jenny Lange, Alison Wood-Kaczmar, Aneesa Ali, Sahar Farag, Rhia Ghosh, Jennifer Parker, Caroline Casey, Yumiko Uno, Akiyoshi Kunugi, Patrizia Ferretti,[...]. Front Cell Neurosci 2021
2

Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties.
Nathan Riguet, Anne-Laure Mahul-Mellier, Niran Maharjan, Johannes Burtscher, Marie Croisier, Graham Knott, Janna Hastings, Alice Patin, Veronika Reiterer, Hesso Farhan,[...]. Nat Commun 2021
7

Progression of basal ganglia pathology in heterozygous Q175 knock-in Huntington's disease mice.
Yunping Deng, Hongbing Wang, Marion Joni, Radhika Sekhri, Anton Reiner. J Comp Neurol 2021
7

Spatiotemporal analysis of soluble aggregates and autophagy markers in the R6/2 mouse model.
M J Vijay Kumar, Devanshi Shah, Mridhula Giridharan, Niraj Yadav, Ravi Manjithaya, James P Clement. Sci Rep 2021
3

Hijacking Endocytosis and Autophagy in Extracellular Vesicle Communication: Where the Inside Meets the Outside.
Giona Pedrioli, Paolo Paganetti. Front Cell Dev Biol 2021
8

Quantification of Huntington's Disease Related Markers in the R6/2 Mouse Model.
Estibaliz Etxeberria-Rekalde, Saioa Alzola-Aldamizetxebarria, Stefanie Flunkert, Isabella Hable, Magdalena Daurer, Joerg Neddens, Birgit Hutter-Paier. Front Mol Neurosci 2021
3

Huntington's Disease: New Frontiers in Therapeutics.
Ling Pan, Andrew Feigin. Curr Neurol Neurosci Rep 2021
7

The heat shock response, determined by QuantiGene multiplex, is impaired in HD mouse models and not caused by HSF1 reduction.
Casandra Gomez-Paredes, Michael A Mason, Bridget A Taxy, Aikaterini S Papadopoulou, Paolo Paganetti, Gillian P Bates. Sci Rep 2021
2

Impaired inhibitory GABAergic synaptic transmission and transcription studied in single neurons by Patch-seq in Huntington's disease.
Foteini Paraskevopoulou, Poorya Parvizi, Gökçe Senger, Nurcan Tuncbag, Christian Rosenmund, Ferah Yildirim. Proc Natl Acad Sci U S A 2021
3

Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates.
Jesús G Galaz-Montoya, Sarah H Shahmoradian, Koning Shen, Judith Frydman, Wah Chiu. Commun Biol 2021
4

Amplification of neurotoxic HTTex1 assemblies in human neurons.
Anjalika Chongtham, J Mario Isas, Nitin K Pandey, Anoop Rawat, Jung Hyun Yoo, Tara Mastro, Mary B Kennedy, Ralf Langen, Ali Khoshnan. Neurobiol Dis 2021
2

Polyglutamine-Specific Gold Nanoparticle Complex Alleviates Mutant Huntingtin-Induced Toxicity.
Devi Wahyuningtyas, Wen-Hao Chen, Ruei-Yu He, Yung-An Huang, Chia-Kang Tsao, Yu-Jung He, Chu-Yi Yu, Po-Chao Lu, Yu-Cai Chen, Sheng-Hann Wang,[...]. ACS Appl Mater Interfaces 2021
0

Development of novel bioassays to detect soluble and aggregated Huntingtin proteins on three technology platforms.
Christian Landles, Rebecca E Milton, Alexandre Jean, Stuart McLarnon, Sean J McAteer, Bridget A Taxy, Georgina F Osborne, Chuangchuang Zhang, Wenzhen Duan, David Howland,[...]. Brain Commun 2021
4

Huntington's disease: nearly four decades of human molecular genetics.
James F Gusella, Jong-Min Lee, Marcy E MacDonald. Hum Mol Genet 2021
3

Mitochondrial Abnormalities and Synaptic Damage in Huntington's Disease: a Focus on Defective Mitophagy and Mitochondria-Targeted Therapeutics.
Neha Sawant, Hallie Morton, Sudhir Kshirsagar, Arubala P Reddy, P Hemachandra Reddy. Mol Neurobiol 2021
6

No symphony without bassoon and piccolo: changes in synaptic active zone proteins in Huntington's disease.
Ting-Ting Huang, Ruben Smith, Karl Bacos, Dong-Yan Song, Richard M Faull, Henry J Waldvogel, Jia-Yi Li. Acta Neuropathol Commun 2020
2

Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA.
Angelique R Ormsby, Dezerae Cox, James Daly, David Priest, Elizabeth Hinde, Danny M Hatters. PLoS One 2020
2

Investigating the Structure of Neurotoxic Protein Aggregates Inside Cells.
Felix J B Bäuerlein, Rubén Fernández-Busnadiego, Wolfgang Baumeister. Trends Cell Biol 2020
10

Effects of flanking sequences and cellular context on subcellular behavior and pathology of mutant HTT.
Anjalika Chongtham, Douglas J Bornemann, Brett A Barbaro, Tamas Lukacsovich, Namita Agrawal, Adeela Syed, Shane Worthge, Judith Purcell, John Burke, Theodore M Chin,[...]. Hum Mol Genet 2020
7

Do Post-Translational Modifications Influence Protein Aggregation in Neurodegenerative Diseases: A Systematic Review.
Larissa-Nele Schaffert, Wayne G Carter. Brain Sci 2020
43

Dysregulated Brain Cholesterol Metabolism Is Linked to Neuroinflammation in Huntington's Disease.
Edith González-Guevara, Graciela Cárdenas, Francisca Pérez-Severiano, Juan Carlos Martínez-Lazcano. Mov Disord 2020
14

A Crucial Role for the Protein Quality Control System in Motor Neuron Diseases.
Riccardo Cristofani, Valeria Crippa, Maria Elena Cicardi, Barbara Tedesco, Veronica Ferrari, Marta Chierichetti, Elena Casarotto, Margherita Piccolella, Elio Messi, Mariarita Galbiati,[...]. Front Aging Neurosci 2020
5

Antisense Transcription across Nucleotide Repeat Expansions in Neurodegenerative and Neuromuscular Diseases: Progress and Mysteries.
Ana F Castro, Joana R Loureiro, José Bessa, Isabel Silveira. Genes (Basel) 2020
4

Correlations Between Mutant Huntingtin Aggregates and Behavioral Changes in R6/1 Mice.
Magali Cabanas, Marion Piquemal, Cristiana Pistono, Syndelle Arnaud, Divyangana Rakesh, Elodie Poinama, Jean-Louis Guillou, Maurice Garret, Yoon H Cho. J Huntingtons Dis 2020
2

Altered Levels and Isoforms of Tau and Nuclear Membrane Invaginations in Huntington's Disease.
Marta Fernández-Nogales, José J Lucas. Front Cell Neurosci 2020
13

The impact of proteostasis dysfunction secondary to environmental and genetic causes on neurodegenerative diseases progression and potential therapeutic intervention.
Abdelmagid M Elmatboly, Ahmed M Sherif, Dalia A Deeb, Amira Benmelouka, May N Bin-Jumah, Lotfi Aleya, Mohamed M Abdel-Daim. Environ Sci Pollut Res Int 2020
1

An Optimization of AAV-82Q-Delivered Rat Model of Huntington's Disease.
Kyoung-Ha So, Jai Ho Choi, Jaisan Islam, Elina Kc, Hyeong Cheol Moon, So Yoon Won, Hyong Kyu Kim, Soochong Kim, Sang-Hwan Hyun, Young Seok Park. J Korean Neurosurg Soc 2020
3


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